UniProtKB - P0A5X9 (RNPA_MYCBO)
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Protein
Ribonuclease P protein component
Gene
rnpA
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Functioni
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.UniRule annotation
Catalytic activityi
Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation
GO - Molecular functioni
- ribonuclease P activity Source: UniProtKB-EC
- tRNA binding Source: InterPro
GO - Biological processi
- tRNA processing Source: UniProtKB-KW
Keywordsi
Molecular function | Endonuclease, Hydrolase, Nuclease, RNA-binding |
Biological process | tRNA processing |
Enzyme and pathway databases
BioCyci | MBOV233413:G1GT4-4149-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: Ribonuclease P protein componentUniRule annotation (EC:3.1.26.5UniRule annotation)Short name: RNase P proteinUniRule annotation Short name: RNaseP proteinUniRule annotation Alternative name(s): Protein C5UniRule annotation |
Gene namesi | Name:rnpAUniRule annotation Ordered Locus Names:BQ2027_MB3954C |
Organismi | Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) |
Taxonomic identifieri | 233413 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000198495 | 1 – 116 | Ribonuclease P protein componentAdd BLAST | 116 |
Interactioni
Subunit structurei
Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.UniRule annotation
Structurei
3D structure databases
ProteinModelPortali | P0A5X9. |
SMRi | P0A5X9. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the RnpA family.UniRule annotation
Phylogenomic databases
HOGENOMi | HOG000266301. |
Family and domain databases
Gene3Di | 3.30.230.10. 1 hit. |
HAMAPi | MF_00227. RNase_P. 1 hit. |
InterProi | View protein in InterPro IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR000100. RNase_P. IPR020539. RNase_P_CS. |
PANTHERi | PTHR33992. PTHR33992. 1 hit. |
Pfami | View protein in Pfam PF00825. Ribonuclease_P. 1 hit. |
SUPFAMi | SSF54211. SSF54211. 1 hit. |
TIGRFAMsi | TIGR00188. rnpA. 1 hit. |
PROSITEi | View protein in PROSITE PS00648. RIBONUCLEASE_P. 1 hit. |
i Sequence
Sequence statusi: Complete.
P0A5X9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRARNRMRR SADFETTVKH GMRTVRSDMV VYWWRGSGGG PRVGLIIAKS
60 70 80 90 100
VGSAVERHRV ARRLRHVAGS IVKELHPSDH VVIRALPSSR HVSSARLEQQ
110
LRCGLRRAVE LAGSDR
Sequence cautioni
The sequence SIU02585 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LT708304 Genomic DNA. Translation: SIU02585.1. Different initiation. |
RefSeqi | NP_857589.2. NC_002945.3. |
Genome annotation databases
EnsemblBacteriai | CDO45226; CDO45226; Mb3954c. |
KEGGi | mbo:Mb3954c. |
PATRICi | fig|233413.5.peg.4332. |
Similar proteinsi
Entry informationi
Entry namei | RNPA_MYCBO | |
Accessioni | P0A5X9Primary (citable) accession number: P0A5X9 Secondary accession number(s): A0A1R3Y6Z0 X2BQ52 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | March 15, 2005 | |
Last modified: | March 28, 2018 | |
This is version 74 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |