P0A5T5 (PUR7_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6

Alternative name(s):
SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	Mb0803

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137		PRO_0000100844

Sequences

	Sequence		Length	Mass (Da)
	P0A5T5 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 200D1EA37DF98637	FASTA	297	32,930
	10 20 30 40 50 60 MRPALSDYQH VASGKVREIY RVDDEHLLLV ASDRISAYDY VLDSTIPDKG RVLTAMSAFF 70 80 90 100 110 120 FGLVDAPNHL AGPPDDPRIP DEVLGRALVV RRLEMLPVEC VARGYLTGSG LLDYQATGKV 130 140 150 160 170 180 CGIALPPGLV EASRFATPLF TPATKAALGD HDENISFDRV VEMVGALRAN QLRDRTLQTY 190 200 210 220 230 240 VQAADHALTR GIIIADTKFE FGIDRHGNLL LADEIFTPDS SRYWPADDYR AGVVQTSFDK 250 260 270 280 290 QFVRSWLTGS ESGWDRGSDR PPPPLPEHIV EATRARYINA YERISELKFD DWIGPGA

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248336 Genomic DNA. Translation: CAD93665.1.
RefSeq	NP_854461.1. NC_002945.3.
3D structure databases
ProteinModelPortal	P0A5T5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000014897; EBMYCP00000014732; EBMYCG00000014894.
GeneID	1092526.
GenomeReviews	Gene locus Mb0803 in contig BX248333_GR.
KEGG	mbo:Mb0803.
PATRIC	18003421. VBIMycBov88188_0873.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000017539.
HOGENOM	HBG555040.
OMA	LTLMDEV.
ProtClustDB	PRK13961.
Enzyme and pathway databases
BioCyc	MBOV233413:MB0803-MONOMER.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. PurC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_MYCBO

Accession

Primary (citable) accession number: P0A5T5
Secondary accession number(s): P77904, Q59566

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program