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Protein

NAD kinase

Gene

nadK

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei85Proton acceptorUniRule annotation1
Binding sitei90NADUniRule annotation1
Binding sitei189NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi85 – 86NADUniRule annotation2
Nucleotide bindingi159 – 160NADUniRule annotation2
Nucleotide bindingi200 – 205NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Mb1721
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001206361 – 307NAD kinaseAdd BLAST307

Proteomic databases

PRIDEiP0A5S7.

Structurei

3D structure databases

ProteinModelPortaliP0A5S7.
SMRiP0A5S7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227223.
KOiK00858.
OMAiGVLWCDG.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A5S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAHRSVLLV VHTGRDEATE TARRVEKVLG DNKIALRVLS AEAVDRGSLH
60 70 80 90 100
LAPDDMRAMG VEIEVVDADQ HAADGCELVL VLGGDGTFLR AAELARNASI
110 120 130 140 150
PVLGVNLGRI GFLAEAEAEA IDAVLEHVVA QDYRVEDRLT LDVVVRQGGR
160 170 180 190 200
IVNRGWALNE VSLEKGPRLG VLGVVVEIDG RPVSAFGCDG VLVSTPTGST
210 220 230 240 250
AYAFSAGGPV LWPDLEAILV VPNNAHALFG RPMVTSPEAT IAIEIEADGH
260 270 280 290 300
DALVFCDGRR EMLIPAGSRL EVTRCVTSVK WARLDSAPFT DRLVRKFRLP

VTGWRGK
Length:307
Mass (Da):32,904
Last modified:March 15, 2005 - v1
Checksum:i68817BE570B6645B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42970.1.
RefSeqiNP_855374.1. NC_002945.3.
WP_003408383.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO42970; CDO42970; Mb1721.
GeneIDi1092671.
KEGGimbo:Mb1721.
PATRICi18005461. VBIMycBov88188_1877.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42970.1.
RefSeqiNP_855374.1. NC_002945.3.
WP_003408383.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP0A5S7.
SMRiP0A5S7.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP0A5S7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO42970; CDO42970; Mb1721.
GeneIDi1092671.
KEGGimbo:Mb1721.
PATRICi18005461. VBIMycBov88188_1877.

Phylogenomic databases

HOGENOMiHOG000227223.
KOiK00858.
OMAiGVLWCDG.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADK_MYCBO
AccessioniPrimary (citable) accession number: P0A5S7
Secondary accession number(s): O33196, X2BIZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.