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P0A5S5 (PKNB_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase PknB

EC=2.7.11.1
Gene names
Name:pknB
Ordered Locus Names:Mb0014c
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length626 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key component of a signal transduction pathway that regulates cell growth and cell division via phosphorylation of target proteins By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subunit structure

Homodimer By similarity.

Subcellular location

Cell membrane; Single-pass membrane protein By similarity.

Post-translational modification

Autophosphorylated. Dephosphorylated by PstP By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 4 PASTA domains.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 626626Serine/threonine-protein kinase PknB
PRO_0000171206

Regions

Topological domain1 – 332332Cytoplasmic Potential
Transmembrane333 – 35321Helical; Potential
Topological domain354 – 626273Extracellular Potential
Domain11 – 274264Protein kinase
Domain356 – 42267PASTA 1
Domain423 – 49068PASTA 2
Domain491 – 55767PASTA 3
Domain558 – 62669PASTA 4
Nucleotide binding17 – 259ATP By similarity
Nucleotide binding93 – 953ATP By similarity
Nucleotide binding140 – 1434ATP By similarity

Sites

Active site1381Proton acceptor By similarity
Metal binding1431Magnesium By similarity
Metal binding1561Magnesium By similarity
Binding site401ATP By similarity
Binding site1561ATP By similarity

Amino acid modifications

Modified residue1661Phosphoserine; by autocatalysis By similarity
Modified residue1691Phosphoserine; by autocatalysis By similarity
Modified residue1711Phosphothreonine; by autocatalysis By similarity
Modified residue1731Phosphothreonine; by autocatalysis By similarity
Modified residue2941Phosphothreonine; by autocatalysis By similarity
Modified residue2951Phosphoserine; by autocatalysis By similarity
Modified residue3091Phosphothreonine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A5S5 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 6C27EEBE9D5A453B

FASTA62666,510
        10         20         30         40         50         60 
MTTPSHLSDR YELGEILGFG GMSEVHLARD LRLHRDVAVK VLRADLARDP SFYLRFRREA 

        70         80         90        100        110        120 
QNAAALNHPA IVAVYDTGEA ETPAGPLPYI VMEYVDGVTL RDIVHTEGPM TPKRAIEVIA 

       130        140        150        160        170        180 
DACQALNFSH QNGIIHRDVK PANIMISATN AVKVMDFGIA RAIADSGNSV TQTAAVIGTA 

       190        200        210        220        230        240 
QYLSPEQARG DSVDARSDVY SLGCVLYEVL TGEPPFTGDS PVSVAYQHVR EDPIPPSARH 

       250        260        270        280        290        300 
EGLSADLDAV VLKALAKNPE NRYQTAAEMR ADLVRVHNGE PPEAPKVLTD AERTSLLSSA 

       310        320        330        340        350        360 
AGNLSGPRTD PLPRQDLDDT DRDRSIGSVG RWVAVVAVLA VLTVVVTIAI NTFGGITRDV 

       370        380        390        400        410        420 
QVPDVRGQSS ADAIATLQNR GFKIRTLQKP DSTIPPDHVI GTDPAANTSV SAGDEITVNV 

       430        440        450        460        470        480 
STGPEQREIP DVSTLTYAEA VKKLTAAGFG RFKQANSPST PELVGKVIGT NPPANQTSAI 

       490        500        510        520        530        540 
TNVVIIIVGS GPATKDIPDV AGQTVDVAQK NLNVYGFTKF SQASVDSPRP AGEVTGTNPP 

       550        560        570        580        590        600 
AGTTVPVDSV IELQVSKGNQ FVMPDLSGMF WVDAEPRLRA LGWTGMLDKG ADVDAGGSQH 

       610        620 
NRVVYQNPPA GTGVNRDGII TLRFGQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248334 Genomic DNA. Translation: CAD92876.1.
RefSeqNP_853684.1. NC_002945.3.

3D structure databases

ProteinModelPortalP0A5S5.
SMRP0A5S5. Positions 2-287, 355-626.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb0014c.

Chemistry

BindingDBP0A5S5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD92876; CAD92876; Mb0014c.
GeneID1090759.
KEGGmbo:Mb0014c.
PATRIC18001697. VBIMycBov88188_0018.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000037185.
KOK08884.
OMATGKDPGT.
OrthoDBEOG6B35XT.
ProtClustDBCLSK790192.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR005543. PASTA.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF03793. PASTA. 4 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00740. PASTA. 4 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51178. PASTA. 4 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePKNB_MYCBO
AccessionPrimary (citable) accession number: P0A5S5
Secondary accession number(s): P71584
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families