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P0A5P1

- CMAS2_MYCBO

UniProt

P0A5P1 - CMAS2_MYCBO

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Protein
Cyclopropane mycolic acid synthase 2
Gene
cmaA2, cma2, Mb0515c
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of trans cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proximal position of an oxygenated mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. In the absence of MmaA2, CmaA2 has a non-specific cis-cyclopropanating activity and is able to catalyze the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence By similarity.

Catalytic activityi

S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei284 – 2841 By similarity

GO - Molecular functioni

  1. cyclopropane-fatty-acyl-phospholipid synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00915.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclopropane mycolic acid synthase 2 (EC:2.1.1.79)
Short name:
CMAS
Alternative name(s):
Cyclopropane-fatty-acyl-phospholipid synthase
Short name:
CFA synthase
Short name:
Cyclopropane fatty acid synthase
Mycolic acid methyltransferase
Short name:
MA-MT
S-adenosylmethionine-dependent methyltransferase
Short name:
AdoMet-MT
Short name:
SAM-MT
Gene namesi
Name:cmaA2
Synonyms:cma2
Ordered Locus Names:Mb0515c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Cyclopropane mycolic acid synthase 2
PRO_0000089567Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi233413.Mb0515c.

Structurei

3D structure databases

ProteinModelPortaliP0A5P1.
SMRiP0A5P1. Positions 12-302.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 422S-adenosyl-L-methionine binding By similarity
Regioni76 – 849S-adenosyl-L-methionine binding By similarity
Regioni102 – 1076S-adenosyl-L-methionine binding By similarity
Regioni131 – 1322S-adenosyl-L-methionine binding By similarity

Sequence similaritiesi

Belongs to the CFA/CMAS family.

Phylogenomic databases

eggNOGiCOG2230.
HOGENOMiHOG000245191.
KOiK00574.
OMAiDASWERY.
OrthoDBiEOG6BGNZP.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR003333. Mycolic_cyclopropane_synthase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF02353. CMAS. 1 hit.
[Graphical view]
PIRSFiPIRSF003085. CMAS. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A5P1-1 [UniParc]FASTAAdd to Basket

« Hide

MTSQGDTTSG TQLKPPVEAV RSHYDKSNEF FKLWLDPSMT YSCAYFERPD    50
MTLEEAQYAK RKLALDKLNL EPGMTLLDIG CGWGSTMRHA VAEYDVNVIG 100
LTLSENQYAH DKAMFDEVDS PRRKEVRIQG WEEFDEPVDR IVSLGAFEHF 150
ADGAGDAGFE RYDTFFKKFY NLTPDDGRML LHTITIPDKE EAQELGLTSP 200
MSLLRFIKFI LTEIFPGGRL PRISQVDYYS SNAGWKVERY HRIGANYVPT 250
LNAWADALQA HKDEAIALKG QETYDIYMHY LRGCSDLFRD KYTDVCQFTL 300
VK 302
Length:302
Mass (Da):34,660
Last modified:March 15, 2005 - v1
Checksum:i63AAA95627F95755
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO41756.1.
RefSeqiNP_854178.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD93378; CAD93378; Mb0515c.
GeneIDi1091574.
KEGGimbo:Mb0515c.
PATRICi18002785. VBIMycBov88188_0561.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO41756.1 .
RefSeqi NP_854178.1. NC_002945.3.

3D structure databases

ProteinModelPortali P0A5P1.
SMRi P0A5P1. Positions 12-302.
ModBasei Search...

Protein-protein interaction databases

STRINGi 233413.Mb0515c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD93378 ; CAD93378 ; Mb0515c .
GeneIDi 1091574.
KEGGi mbo:Mb0515c.
PATRICi 18002785. VBIMycBov88188_0561.

Phylogenomic databases

eggNOGi COG2230.
HOGENOMi HOG000245191.
KOi K00574.
OMAi DASWERY.
OrthoDBi EOG6BGNZP.

Enzyme and pathway databases

UniPathwayi UPA00915 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR003333. Mycolic_cyclopropane_synthase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF02353. CMAS. 1 hit.
[Graphical view ]
PIRSFi PIRSF003085. CMAS. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiCMAS2_MYCBO
AccessioniPrimary (citable) accession number: P0A5P1
Secondary accession number(s): Q11196, X2BFA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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