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P0A5P1

- CMAS2_MYCBO

UniProt

P0A5P1 - CMAS2_MYCBO

Protein

Cyclopropane mycolic acid synthase 2

Gene

cmaA2

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of trans cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proximal position of an oxygenated mycolic acid via the transfer of a methylene group from S-adenosyl-L-methionine. In the absence of MmaA2, CmaA2 has a non-specific cis-cyclopropanating activity and is able to catalyze the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei284 – 2841By similarity

    GO - Molecular functioni

    1. cyclopropane-fatty-acyl-phospholipid synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00915.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclopropane mycolic acid synthase 2 (EC:2.1.1.79)
    Short name:
    CMAS
    Alternative name(s):
    Cyclopropane-fatty-acyl-phospholipid synthase
    Short name:
    CFA synthase
    Short name:
    Cyclopropane fatty acid synthase
    Mycolic acid methyltransferase
    Short name:
    MA-MT
    S-adenosylmethionine-dependent methyltransferase
    Short name:
    AdoMet-MT
    Short name:
    SAM-MT
    Gene namesi
    Name:cmaA2
    Synonyms:cma2
    Ordered Locus Names:Mb0515c
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302Cyclopropane mycolic acid synthase 2PRO_0000089567Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi233413.Mb0515c.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A5P1.
    SMRiP0A5P1. Positions 12-302.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni41 – 422S-adenosyl-L-methionine bindingBy similarity
    Regioni76 – 849S-adenosyl-L-methionine bindingBy similarity
    Regioni102 – 1076S-adenosyl-L-methionine bindingBy similarity
    Regioni131 – 1322S-adenosyl-L-methionine bindingBy similarity

    Sequence similaritiesi

    Belongs to the CFA/CMAS family.Curated

    Phylogenomic databases

    eggNOGiCOG2230.
    HOGENOMiHOG000245191.
    KOiK00574.
    OMAiDASWERY.
    OrthoDBiEOG6BGNZP.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR003333. Mycolic_cyclopropane_synthase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF02353. CMAS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003085. CMAS. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P0A5P1-1 [UniParc]FASTAAdd to Basket

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    MTSQGDTTSG TQLKPPVEAV RSHYDKSNEF FKLWLDPSMT YSCAYFERPD    50
    MTLEEAQYAK RKLALDKLNL EPGMTLLDIG CGWGSTMRHA VAEYDVNVIG 100
    LTLSENQYAH DKAMFDEVDS PRRKEVRIQG WEEFDEPVDR IVSLGAFEHF 150
    ADGAGDAGFE RYDTFFKKFY NLTPDDGRML LHTITIPDKE EAQELGLTSP 200
    MSLLRFIKFI LTEIFPGGRL PRISQVDYYS SNAGWKVERY HRIGANYVPT 250
    LNAWADALQA HKDEAIALKG QETYDIYMHY LRGCSDLFRD KYTDVCQFTL 300
    VK 302
    Length:302
    Mass (Da):34,660
    Last modified:March 15, 2005 - v1
    Checksum:i63AAA95627F95755
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO41756.1.
    RefSeqiNP_854178.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD93378; CAD93378; Mb0515c.
    GeneIDi1091574.
    KEGGimbo:Mb0515c.
    PATRICi18002785. VBIMycBov88188_0561.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO41756.1 .
    RefSeqi NP_854178.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali P0A5P1.
    SMRi P0A5P1. Positions 12-302.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb0515c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD93378 ; CAD93378 ; Mb0515c .
    GeneIDi 1091574.
    KEGGi mbo:Mb0515c.
    PATRICi 18002785. VBIMycBov88188_0561.

    Phylogenomic databases

    eggNOGi COG2230.
    HOGENOMi HOG000245191.
    KOi K00574.
    OMAi DASWERY.
    OrthoDBi EOG6BGNZP.

    Enzyme and pathway databases

    UniPathwayi UPA00915 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR003333. Mycolic_cyclopropane_synthase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF02353. CMAS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003085. CMAS. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiCMAS2_MYCBO
    AccessioniPrimary (citable) accession number: P0A5P1
    Secondary accession number(s): Q11196, X2BFA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3