Reviewed,
UniProtKB/Swiss-Prot P0A5N5 (AHPD_MYCBO)
Last modified
February 9, 2010.
Version 28.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Alkyl hydroperoxide reductase ahpD EC=1.11.1.15 Alternative name(s): Alkylhydroperoxidase ahpD | ||||
| Gene names |
| ||||
| Organism | Mycobacterium bovis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1765 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 177 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the ahpC active site cysteine residues and for the regeneration of the ahpC enzyme activity By similarity. HAMAP MF_01676 |
| Catalytic activity | 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676 |
| Subunit structure | Homotrimer By similarity. HAMAP MF_01676 |
| Sequence similarities | Belongs to the ahpD family. |
Ontologies
| Keywords | |
|---|---|
| Domain | Redox-active center |
| Molecular function | Antioxidant Oxidoreductase Peroxidase |
| PTM | Disulfide bond |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | alkyl hydroperoxide reductase activity Inferred from electronic annotation. Source: HAMAP peroxiredoxin activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 177 | 177 | Alkyl hydroperoxide reductase ahpD HAMAP MF_01676 | PRO_0000064505 | |||||||
Sites | |||||||||||
| Active site | 130 | 1 | Proton donor By similarity | ||||||||
| Active site | 133 | 1 | Cysteine sulfenic acid (-SOH) intermediate By similarity | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 130 ↔ 133 | Alternate By similarity | |||||||||
| Disulfide bond | 133 | Interchain (with ahpC); in linked form By similarity | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "ahpC, a gene involved in isoniazid resistance of the Mycobacterium tuberculosis complex." Wilson T.M., Collins D.M. Mol. Microbiol. 19:1025-1034(1996) [PubMed: 8830260] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 35723 / TMC 405 and ATCC 35729 / TMC 606. |
| [2] | "The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. Hewinson R.G.Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U24083 Genomic DNA. Translation: AAB60204.1. U24084 Genomic DNA. Translation: AAB38113.1. BX248342 Genomic DNA. Translation: CAD97316.1. |
| PIR | S71014. |
| RefSeq | NP_856102.1. |
3D structure databases | |
| SMR | P0A5N5. Positions 2-175. |
| ModBase | Search... |
Protein family/group databases | |
| PeroxiBase | 4577. MboAhpD. |
Genome annotation databases | |
| GeneID | 1094261. |
| KEGG | mbo:Mb2455. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG414634. |
| OMA | RAGLRMN. |
Enzyme and pathway databases | |
| BioCyc | MBOV233413:MB2455-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01676. AhpD. [Tree] |
| InterPro | IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view] |
| Pfam | PF02627. CMD. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00777. ahpD. 1 hit. TIGR00778. ahpD_dom. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | AHPD_MYCBO | ||||||||
| Accession | Primary (citable) accession number: P0A5N5 Secondary accession number(s): Q57353 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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