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P0A5M7 (PYRF_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Synonyms:uraA
Ordered Locus Names:Mb1420
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' UMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

'de novo' pyrimidine nucleobase biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionorotidine-5'-phosphate decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01215
PRO_0000134631

Sites

Active site951Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A5M7 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 369BAE076FB3D143

FASTA27427,377
        10         20         30         40         50         60 
MTGFGLRLAE AKARRGPLCL GIDPHPELLR GWDLATTADG LAAFCDICVR AFADFAVVKP 

        70         80         90        100        110        120 
QVAFFESYGA AGFAVLERTI AELRAADVLV LADAKRGDIG ATMSAYATAW VGDSPLAADA 

       130        140        150        160        170        180 
VTASPYLGFG SLRPLLEVAA AHGRGVFVLA ATSNPEGAAV QNAAADGRSV AQLVVDQVGA 

       190        200        210        220        230        240 
ANEAAGPGPG SIGVVVGATA PQAPDLSAFT GPVLVPGVGV QGGRPEALGG LGGAASSQLL 

       250        260        270 
PAVAREVLRA GPGVPELRAA GERMRDAVAY LAAV 

« Hide

References

« Hide 'large scale' references
[1]"The uraA locus and homologous recombination in Mycobacterium bovis BCG."
Aldovini A., Husson R.N., Young R.A.
J. Bacteriol. 175:7282-7289(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BCG.
[2]"The complete genome sequence of Mycobacterium bovis."
Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. expand/collapse author list , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.
Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U01072 Unassigned DNA. Translation: AAC43182.1.
BX248333 Genomic DNA. Translation: CDO42668.1.
PIRB49930.
RefSeqNP_855072.1. NC_002945.3.

3D structure databases

ProteinModelPortalP0A5M7.
SMRP0A5M7. Positions 4-268.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb1420.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD94281; CAD94281; Mb1420.
GeneID1090710.
KEGGmbo:Mb1420.
PATRIC18004816. VBIMycBov88188_1555.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000245748.
KOK01591.
OMAGSTMGAY.
OrthoDBEOG6DZF33.

Enzyme and pathway databases

UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01215. OMPdecase_type2.
InterProIPR013785. Aldolase_TIM.
IPR018089. OMPdecase_AS.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02127. pyrF_sub2. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRF_MYCBO
AccessionPrimary (citable) accession number: P0A5M7
Secondary accession number(s): P42610, P77898, X2BHX9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 11, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways