P0A5L9 (NAT_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arylamine N-acetyltransferase
EC=2.3.1.5

Gene names

Name:	nat
Ordered Locus Names:	Mb3596c

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid By similarity.
Catalytic activity	Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the arylamine N-acetyltransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	arylamine N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Arylamine N-acetyltransferase		PRO_0000107917
Sites
	Active site	70	1	Acyl-thioester intermediate By similarity
	Active site	110	1	By similarity
	Active site	127	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0A5L9 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 9C8D98E3256D088A	FASTA	283	31,029
	10 20 30 40 50 60 MALDLTAYFD RINYRGATDP TLDVLQDLVT VHSRTIPFEN LDPLLGVPVD DLSPQALADK 70 80 90 100 110 120 LVLRRRGGYC FEHNGLMGYV LAELGYRVRR FAARVVWKLA PDAPLPPQTH TLLGVTFPGS 130 140 150 160 170 180 GGCYLVDVGF GGQTPTSPLR LETGAVQPTT HEPYRLEDRV DGFVLQAMVR DTWQTLYEFT 190 200 210 220 230 240 TQTRPQIDLK VASWYASTHP ASKFVTGLTA AVITDDARWN LSGRDLAVHR AGGTEKIRLA 250 260 270 280 DAAAVVDTLS ERFGINVADI GERGALETRI DELLARQPGA DAP

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248346 Genomic DNA. Translation: CAD95782.1.
RefSeq	NP_857235.1. NC_002945.3.
3D structure databases
ProteinModelPortal	P0A5L9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000014564; EBMYCP00000014399; EBMYCG00000014561.
GeneID	1093447.
GenomeReviews	Gene locus Mb3596c in contig BX248333_GR.
KEGG	mbo:Mb3596c.
PATRIC	18009623. VBIMycBov88188_3939.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016624.
HOGENOM	HBG544563.
OMA	ENLDPLM.
ProtClustDB	CLSK800002.
Enzyme and pathway databases
BioCyc	MBOV233413:MB3596C-MONOMER.
Family and domain databases
InterPro	IPR001447. N-AcTrfase. [Graphical view]
KO	K00622.
PANTHER	PTHR11786. Acetyltransf2. 1 hit.
Pfam	PF00797. Acetyltransf_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAT_MYCBO

Accession

Primary (citable) accession number: P0A5L9
Secondary accession number(s): P96848

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program