P0A5L8 (NAT_MYCTU) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 52.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Arylamine N-acetyltransferase EC=2.3.1.5 | ||||||
| Gene names |
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| Organism | Mycobacterium tuberculosis [Reference proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1773 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex![]() |
Protein attributes
| Sequence length | 283 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid. |
| Catalytic activity | Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | |
| Miscellaneous | Was identified as a high-confidence drug target. |
| Sequence similarities | Belongs to the arylamine N-acetyltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Molecular function | Acyltransferase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from direct assay PubMed 15525680. Source: MTBBASE |
| Molecular_function | arylamine N-acetyltransferase activity Inferred from direct assay PubMed 18795795Ref.4. Source: MTBBASE |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. Barrell B.G.Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv. |
| [2] | "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv." Camus J.-C., Pryor M.J., Medigue C., Cole S.T. Microbiology 148:2967-2973(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION. |
| [3] | "Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. Fraser C.M.J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh. |
| [4] | "Cloning and characterization of arylamine N-acetyltransferase genes from Mycobacterium smegmatis and Mycobacterium tuberculosis: increased expression results in isoniazid resistance." Payton M.A., Auty R., Delgoda R.T., Everitt M., Sim E. J. Bacteriol. 181:1343-1347(1999) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION. |
| [5] | "targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis." Raman K., Yeturu K., Chandra N. BMC Syst. Biol. 2:109-109(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX842583 Genomic DNA. Translation: CAE55614.1. AE000516 Genomic DNA. Translation: AAK48028.1. AL123456 Genomic DNA. Translation: CCP46388.1. |
| RefSeq | NP_338214.1. NC_002755.2. YP_006517055.1. NC_018143.1. YP_177989.1. NC_000962.3. |
3D structure databases | |
| ProteinModelPortal | P0A5L8. |
| SMR | P0A5L8. Positions 4-273. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 83332.Rv3566c. |
Proteomic databases | |
| PRIDE | P0A5L8. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | AAK48028; AAK48028; MT3671. |
| GeneID | 13317174. 888005. 926546. |
| KEGG | mtc:MT3671. mtu:Rv3566c. mtv:RVBD_3566c. |
| PATRIC | 18129827. VBIMycTub22151_4008. |
Organism-specific databases | |
| TubercuList | Rv3566c. |
Phylogenomic databases | |
| eggNOG | COG2162. |
| HOGENOM | HOG000205436. |
| KO | K00622. |
| OMA | LANPPQM. |
| ProtClustDB | CLSK800002. |
Family and domain databases | |
| InterPro | IPR001447. Arylamine_N-AcTrfase. [Graphical view] |
| PANTHER | PTHR11786. PTHR11786. 1 hit. |
| Pfam | PF00797. Acetyltransf_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NAT_MYCTU | ||||||||
| Accession | Primary (citable) accession number: P0A5L8 Secondary accession number(s): L0TCY1, P96848 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with
