P0A5L8 (NAT_MYCTU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 41.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Arylamine N-acetyltransferase EC=2.3.1.5 | ||||||
| Gene names |
| ||||||
| Organism | Mycobacterium tuberculosis | ||||||
| Taxonomic identifier | 1773 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 283 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid. |
| Catalytic activity | Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | |
| Miscellaneous | Was identified as a high-confidence drug target. |
| Sequence similarities | Belongs to the arylamine N-acetyltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Molecular function | Acyltransferase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from direct assay. Source: MTBBASE |
| Molecular function | arylamine N-acetyltransferase activity Inferred from direct assay Ref.4. Source: MTBBASE |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. Barrell B.G.Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv. |
| [2] | "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv." Camus J.-C., Pryor M.J., Medigue C., Cole S.T. Microbiology 148:2967-2973(2002) [PubMed: 12368430] [Abstract] Cited for: SEQUENCE REVISION. |
| [3] | "Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. Fraser C.M.J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh. |
| [4] | "Cloning and characterization of arylamine N-acetyltransferase genes from Mycobacterium smegmatis and Mycobacterium tuberculosis: increased expression results in isoniazid resistance." Payton M.A., Auty R., Delgoda R.T., Everitt M., Sim E. J. Bacteriol. 181:1343-1347(1999) [PubMed: 9973365] [Abstract] Cited for: CHARACTERIZATION. |
| [5] | "targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis." Raman K., Yeturu K., Chandra N. BMC Syst. Biol. 2:109-109(2008) [PubMed: 19099550] [Abstract] Cited for: IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX842583 Genomic DNA. Translation: CAE55614.1. AE000516 Genomic DNA. Translation: AAK48028.1. |
| RefSeq | NP_338214.1. NC_002755.2. YP_177989.1. NC_000962.2. |
3D structure databases | |
| ProteinModelPortal | P0A5L8. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBMYCT00000001364; EBMYCP00000001364; EBMYCG00000001364. EBMYCT00000070287; EBMYCP00000068346; EBMYCG00000070282. |
| GeneID | 888005. 926546. |
| GenomeReviews | Gene locus MT3671 in contig AE000516_GR. Gene locus Rv3566c in contig AL123456_GR. |
| KEGG | mtc:MT3671. mtu:Rv3566c. |
| PATRIC | 18129827. VBIMycTub22151_4008. |
| TIGR | MT3671. |
Organism-specific databases | |
| TubercuList | Rv3566c. |
Phylogenomic databases | |
| GeneTree | EBGT00050000016624. |
| HOGENOM | HBG544563. |
| OMA | ENLDPLM. |
| PhylomeDB | P0A5L8. |
| ProtClustDB | CLSK800002. |
Family and domain databases | |
| InterPro | IPR001447. N-AcTrfase. [Graphical view] |
| KO | K00622. |
| PANTHER | PTHR11786. Acetyltransf2. 1 hit. |
| Pfam | PF00797. Acetyltransf_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NAT_MYCTU | ||||||||
| Accession | Primary (citable) accession number: P0A5L8 Secondary accession number(s): P96848 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with