Reviewed,
UniProtKB/Swiss-Prot P0A5L8 (NAT_MYCTU)
Last modified
November 3, 2009.
Version 25.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Arylamine N-acetyltransferase EC=2.3.1.5 | ||||||
| Gene names |
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| Organism | Mycobacterium tuberculosis [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1773 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 283 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Could have a role in acetylating, and hence inactivating, the antitubercular drug isoniazid. |
| Catalytic activity | Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. |
| Subunit structure | Homodimer By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the arylamine N-acetyltransferase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Molecular function | Acyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | arylamine N-acetyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. Barrell B.G.Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv. |
| [2] | "Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv." Camus J.-C., Pryor M.J., Medigue C., Cole S.T. Microbiology 148:2967-2973(2002) [PubMed: 12368430] [Abstract] Cited for: SEQUENCE REVISION. |
| [3] | "Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. Fraser C.M.J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh. |
| [4] | "Cloning and characterization of arylamine N-acetyltransferase genes from Mycobacterium smegmatis and Mycobacterium tuberculosis: increased expression results in isoniazid resistance." Payton M.A., Auty R., Delgoda R.T., Everitt M., Sim E. J. Bacteriol. 181:1343-1347(1999) [PubMed: 9973365] [Abstract] Cited for: CHARACTERIZATION. |
Cross-references
Sequence databases | |
|---|---|
| BX842583 Genomic DNA. Translation: CAE55614.1. AE000516 Genomic DNA. Translation: AAK48028.1. | |
| RefSeq | NP_338214.1. YP_177989.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GX3 based on UniProtKB O86309. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 888005. 926546. |
| GenomeReviews | Gene locus MT3671 in contig AE000516_GR. Gene locus Rv3566c in contig AL123456_GR. |
| KEGG | mtc:MT3671. mtu:Rv3566c. |
| TIGR | MT3671. |
Organism-specific databases | |
| TubercuList | Rv3566c. |
Phylogenomic databases | |
| HOGENOM | P0A5L8. |
| OMA | HMLLRVE. |
Enzyme and pathway databases | |
| BRENDA | 2.3.1.5. 809. |
Family and domain databases | |
| InterPro | IPR001447. N-AcTrfase. [Graphical view] |
| PANTHER | PTHR11786. Acetyltransf2. 1 hit. |
| Pfam | PF00797. Acetyltransf_2. 1 hit. [Graphical view] |
| ProDom | PD002783. Acetyltransf2. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| ProtoNet | Search... |
Entry information
| Entry name | NAT_MYCTU | ||||||||
| Accession | Primary (citable) accession number: P0A5L8 Secondary accession number(s): P96848 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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