Reviewed,
UniProtKB/Swiss-Prot P0A5L5 (MURF_MYCBO)
Last modified
June 16, 2009.
Version 31.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase EC=6.3.2.10 Alternative name(s): UDP-MurNAc-pentapeptide synthetase D-alanyl-D-alanine-adding enzyme | ||||
| Gene names |
| ||||
| Organism | Mycobacterium bovis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1765 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 510 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity. |
| Catalytic activity | ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine. |
| Pathway | |
| Subunit structure | Monomer By similarity. |
| Subcellular location | Cytoplasm Probable. |
| Sequence similarities | Belongs to the murCDEF family. |
Ontologies
Sequence annotation (Features)
Sequences
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References
| [1] | "The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. Hewinson R.G.Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97. |
Cross-references
Sequence databases | |
|---|---|
| BX248341 Genomic DNA. Translation: CAD97034.1. | |
| RefSeq | NP_855830.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GG4 based on UniProtKB P11880. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1091261. |
| GenomeReviews | Gene locus Mb2181c in contig BX248333_GR. |
| KEGG | mbo:Mb2181c. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | P0A5L5. |
| OMA | P0A5L5. LDDTYNA. |
Enzyme and pathway databases | |
| BRENDA | 6.3.2.10. 3091. |
Family and domain databases | |
| InterPro | IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR005863. UDP-N-AcMur-3pep_AlaAla_ligase. [Graphical view] |
| Gene3D | G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. |
| PANTHER | PTHR23135:SF3. MurF. 1 hit. |
| Pfam | PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01143. murF. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | MURF_MYCBO | ||||||||
| Accession | Primary (citable) accession number: P0A5L5 Secondary accession number(s): O06220 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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