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P0A5L0 (MSRA_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase
Gene names
Name:msrA
Ordered Locus Names:Rv0137c, MT0145
ORF Names:MTCI5.11c
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length182 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401

Catalytic activity

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401

L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401

Sequence similarities

Belongs to the MsrA Met sulfoxide reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 182182Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401
PRO_0000138560

Sites

Active site131 By similarity

Secondary structure

1 ............................. 182
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0A5L0 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: B0A2847A699C2016

FASTA18220,485
        10         20         30         40         50         60 
MTSNQKAILA GGCFWGLQDL IRNQPGVVST RVGYSGGNIP NATYRNHGTH AEAVEIIFDP 

        70         80         90        100        110        120 
TVTDYRTLLE FFFQIHDPTT KDRQGNDRGT SYRSAIFYFD EQQKRIALDT IADVEASGLW 

       130        140        150        160        170        180 
PGKVVTEVSP AGDFWEAEPE HQDYLQRYPN GYTCHFVRPG WRLPRRTAES ALRASLSPEL 


GT

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842572 Genomic DNA. Translation: CAB07043.1.
AE000516 Genomic DNA. Translation: AAK44369.1.
PIRD70616.
RefSeqNP_214651.1. NC_000962.2.
NP_334555.1. NC_002755.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1NWAX-ray1.50A1-182[»]
ProteinModelPortalP0A5L0.
SMRP0A5L0. Positions 1-166.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000000702; EBMYCP00000000702; EBMYCG00000000702.
EBMYCT00000069579; EBMYCP00000067638; EBMYCG00000069574.
GeneID886865.
923012.
GenomeReviewsGene locus MT0145 in contig AE000516_GR.
Gene locus Rv0137c in contig AL123456_GR.
KEGGmtc:MT0145.
mtu:Rv0137c.
PATRIC18122047. VBIMycTub22151_0158.
TIGRMT0145.

Organism-specific databases

TubercuListRv0137c.

Phylogenomic databases

GeneTreeEBGT00050000017224.
HOGENOMHBG748152.
OMAYRQILEF.
PhylomeDBP0A5L0.
ProtClustDBPRK14054.

Family and domain databases

HAMAPMF_01401. MsrA.
[Tree]
InterProIPR002569. Peptide_Met_Sox_Rdtase_MsrA.
[Graphical view]
Gene3DG3DSA:3.30.1060.10. MsrA. 1 hit.
KOK07304.
PfamPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMSSF55068. MsrA. 1 hit.
TIGRFAMsTIGR00401. MsrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMSRA_MYCTU
AccessionPrimary (citable) accession number: P0A5L0
Secondary accession number(s): P96814
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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