P0A5K8 (MSCL_MYCTU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 57.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Large-conductance mechanosensitive channel | ||||||
| Gene names |
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| Organism | Mycobacterium tuberculosis | ||||||
| Taxonomic identifier | 1773 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 151 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. HAMAP MF_00115 |
| Subunit structure | Homopentamer By similarity. HAMAP MF_00115 |
| Subcellular location | Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00115. |
| Sequence similarities | Belongs to the MscL family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ion transport Transport |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane Transmembrane helix |
| Molecular function | Ionic channel |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | protein homooligomerization Inferred from physical interaction. Source: MTBBASE |
| Cellular component | integral to plasma membrane Inferred from direct assay. Source: MTBBASE |
| Molecular function | ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW mechanically gated channel activityInferred from direct assay. Source: MTBBASE |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 151 | 151 | Large-conductance mechanosensitive channel HAMAP MF_00115 | PRO_0000192452 | |||||
Regions | |||||||||
| Topological domain | 1 – 14 | 14 | Cytoplasmic By similarity | ||||||
| Transmembrane | 15 – 43 | 29 | Helical; By similarity | ||||||
| Topological domain | 44 – 68 | 25 | Extracellular By similarity | ||||||
| Transmembrane | 69 – 90 | 22 | Helical; By similarity | ||||||
| Topological domain | 91 – 151 | 61 | Cytoplasmic By similarity | ||||||
Sequences
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References
| [1] | "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. Barrell B.G.Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv. |
| [2] | "Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. Fraser C.M.J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX842575 Genomic DNA. Translation: CAA17584.1. AE000516 Genomic DNA. Translation: AAK45261.1. |
| PIR | E70821. |
| RefSeq | NP_215500.1. NC_000962.2. NP_335447.1. NC_002755.2. |
3D structure databases | |
| ProteinModelPortal | P0A5K8. |
| SMR | P0A5K8. Positions 1-125. |
| ModBase | Search... |
Protein family/group databases | |
| TCDB | 1.A.22.1.2. large conductance mechanosensitive ion channel (MscL) family. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBMYCT00000003219; EBMYCP00000003219; EBMYCG00000003217. EBMYCT00000070399; EBMYCP00000068458; EBMYCG00000070394. |
| GeneID | 885368. 925186. |
| GenomeReviews | Gene locus MT1013 in contig AE000516_GR. Gene locus Rv0985c in contig AL123456_GR. |
| KEGG | mtc:MT1013. mtu:Rv0985c. |
| PATRIC | 18123972. VBIMycTub22151_1109. |
| TIGR | MT1013. |
Organism-specific databases | |
| TubercuList | Rv0985c. |
Phylogenomic databases | |
| GeneTree | EBGT00050000017393. |
| HOGENOM | HBG727604. |
| OMA | VIDFVIV. |
| PhylomeDB | P0A5K8. |
| ProtClustDB | PRK00567. |
Family and domain databases | |
| HAMAP | MF_00115. MscL. [Tree] |
| InterPro | IPR019823. Mechanosensitive_channel_CS. IPR001185. MS_channel. [Graphical view] |
| KO | K03282. |
| Pfam | PF01741. MscL. 1 hit. [Graphical view] |
| PRINTS | PR01264. MECHCHANNEL. |
| SUPFAM | SSF81330. MS_channel. 1 hit. |
| TIGRFAMs | TIGR00220. MscL. 1 hit. |
| PROSITE | PS01327. MSCL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MSCL_MYCTU | ||||||||
| Accession | Primary (citable) accession number: P0A5K8 Secondary accession number(s): O53898 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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