P0A5J6 (MDH_MYCTU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 50.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Malate dehydrogenase EC=1.1.1.37 | ||||||
| Gene names |
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| Organism | Mycobacterium tuberculosis | ||||||
| Taxonomic identifier | 1773 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 329 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP MF_01517 |
| Catalytic activity | (S)-malate + NAD+ = oxaloacetate + NADH. HAMAP MF_01517 |
| Subunit structure | Homodimer By similarity. HAMAP MF_01517 |
| Sequence similarities | Belongs to the LDH/MDH superfamily. MDH type 2 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Tricarboxylic acid cycle |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | cellular carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro malate metabolic processInferred from electronic annotation. Source: InterPro tricarboxylic acid cycleInferred from direct assay. Source: MTBBASE |
| Cellular component | cytosol Inferred from direct assay. Source: MTBBASE plasma membraneInferred from direct assay. Source: MTBBASE |
| Molecular function | L-malate dehydrogenase activity Inferred from direct assay. Source: MTBBASE nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 329 | 329 | Malate dehydrogenase HAMAP MF_01517 | PRO_0000113380 | |||||
Regions | |||||||||
| Nucleotide binding | 12 – 18 | 7 | NAD By similarity | ||||||
| Nucleotide binding | 130 – 132 | 3 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 188 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 93 | 1 | Substrate By similarity | ||||||
| Binding site | 99 | 1 | Substrate By similarity | ||||||
| Binding site | 106 | 1 | NAD By similarity | ||||||
| Binding site | 113 | 1 | NAD By similarity | ||||||
| Binding site | 132 | 1 | Substrate By similarity | ||||||
| Binding site | 163 | 1 | Substrate By similarity | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX842576 Genomic DNA. Translation: CAA15896.1. AE000516 Genomic DNA. Translation: AAK45536.1. |
| PIR | G70952. |
| RefSeq | NP_215756.1. NC_000962.2. NP_335722.1. NC_002755.2. |
3D structure databases | |
| ProteinModelPortal | P0A5J6. |
| SMR | P0A5J6. Positions 4-329. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBMYCT00000000490; EBMYCP00000000490; EBMYCG00000000490. EBMYCT00000071958; EBMYCP00000070017; EBMYCG00000071953. |
| GeneID | 887119. 924783. |
| GenomeReviews | Gene locus MT1278 in contig AE000516_GR. Gene locus Rv1240 in contig AL123456_GR. |
| KEGG | mtc:MT1278. mtu:Rv1240. |
| PATRIC | 18124576. VBIMycTub22151_1407. |
| TIGR | MT1278. |
Organism-specific databases | |
| TubercuList | Rv1240. |
Phylogenomic databases | |
| GeneTree | EBGT00050000018111. |
| HOGENOM | HBG289884. |
| OMA | NKIQISL. |
| PhylomeDB | P0A5J6. |
| ProtClustDB | PRK05442. |
Enzyme and pathway databases | |
| BioCyc | MetaCyc:MONOMER-11949. |
Family and domain databases | |
| HAMAP | MF_01517. Malate_dehydrog_2. [Tree] |
| InterPro | IPR001557. L-lactate/malate_DH. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR001252. Malate_DH_AS. IPR010945. Malate_DH_type2. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.90.110.10. lact_mal_DH. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| KO | K00024. |
| PANTHER | PTHR23382. MDH_SF1. 1 hit. |
| Pfam | PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view] |
| PIRSF | PIRSF000102. Lac_mal_DH. 1 hit. |
| SUPFAM | SSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit. |
| TIGRFAMs | TIGR01759. MalateDH-SF1. 1 hit. |
| PROSITE | PS00068. MDH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MDH_MYCTU | ||||||||
| Accession | Primary (citable) accession number: P0A5J6 Secondary accession number(s): O54592 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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