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Protein

Lipoprotein LpqH

Gene

lpqH

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Might be involved in ligand transport. A host TLR2 agonist, modifies host gene expression in response to pathogen.By similarity

GO - Biological processi

Keywordsi

Biological processTransport, Virulence

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-3976-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein LpqH
Alternative name(s):
19 kDa lipoprotein antigen
Putative transporter LpqH
Gene namesi
Name:lpqH
Ordered Locus Names:BQ2027_MB3789
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21CuratedAdd BLAST21
ChainiPRO_000001812622 – 159Lipoprotein LpqHAdd BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi22N-palmitoyl cysteineCurated1
Lipidationi22S-diacylglycerol cysteineCurated1

Post-translational modificationi

Modified by Lgt on Cys-22 with an S-linked diacylglycerol with a mixture of C16, C18 and C19 fatty acids, signal peptide is removed by LspA, modifed by Lnt with an amide-linked mixture of C16 and C19 fatty acids.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Structurei

3D structure databases

ProteinModelPortaliP0A5J1
SMRiP0A5J1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a U-shaped beta-half-barrel with a large hydrophobic cavity.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000042299
OMAiCSDMGGN

Family and domain databases

InterProiView protein in InterPro
IPR008691 LpqH
PfamiView protein in Pfam
PF05481 Myco_19_kDa, 1 hit
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A5J1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRGLTVAVA GAAILVAGLS GCSSNKSTTG SGETTTAAGT TASPGAASGP
60 70 80 90 100
KVVIDGKDQN VTGSVVCTTA AGNVNIAIGG AATGIAAVLT DGNPPEVKSV
110 120 130 140 150
GLGNVNGVTL GYTSGTGQGN ASATKDGSHY KITGTATGVD MANPMSPVNK

SFEIEVTCS
Length:159
Mass (Da):15,147
Last modified:March 15, 2005 - v1
Checksum:iCB1A5090E14867BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15803 Genomic DNA Translation: CAA33802.1
LT708304 Genomic DNA Translation: SIU02418.1
PIRiS11234
RefSeqiNP_857426.1, NC_002945.3
WP_003420544.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO45061; CDO45061; Mb3789
PATRICifig|233413.5.peg.4145

Similar proteinsi

Entry informationi

Entry nameiLPQH_MYCBO
AccessioniPrimary (citable) accession number: P0A5J1
Secondary accession number(s): A0A1R3Y556, P11572, X2BQ19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 25, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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