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Protein

Lipoprotein LpqH

Gene

lpqH

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Might be involved in ligand transport. A host TLR2 agonist, modifies host gene expression in response to pathogen.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoprotein LpqH
Alternative name(s):
19 kDa lipoprotein antigen
Putative transporter LpqH
Gene namesi
Name:lpqH
Ordered Locus Names:Mb3789
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121CuratedAdd
BLAST
Chaini22 – 159138Lipoprotein LpqHPRO_0000018126Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi22 – 221N-palmitoyl cysteineCurated
Lipidationi22 – 221S-diacylglycerol cysteineCurated

Post-translational modificationi

Modified by Lgt on Cys-22 with an S-linked diacylglycerol with a mixture of C16, C18 and C19 fatty acids, signal peptide is removed by LspA, modifed by Lnt with an amide-linked mixture of C16 and C19 fatty acids.By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Structurei

3D structure databases

ProteinModelPortaliP0A5J1.
SMRiP0A5J1. Positions 49-158.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a U-shaped beta-half-barrel with a large hydrophobic cavity.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000042299.
KOiK14953.
OMAiNKPFEIE.
OrthoDBiEOG6F29BX.

Family and domain databases

InterProiIPR008691. LpqH.
[Graphical view]
PfamiPF05481. Myco_19_kDa. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A5J1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRGLTVAVA GAAILVAGLS GCSSNKSTTG SGETTTAAGT TASPGAASGP
60 70 80 90 100
KVVIDGKDQN VTGSVVCTTA AGNVNIAIGG AATGIAAVLT DGNPPEVKSV
110 120 130 140 150
GLGNVNGVTL GYTSGTGQGN ASATKDGSHY KITGTATGVD MANPMSPVNK

SFEIEVTCS
Length:159
Mass (Da):15,147
Last modified:March 15, 2005 - v1
Checksum:iCB1A5090E14867BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15803 Genomic DNA. Translation: CAA33802.1.
BX248333 Genomic DNA. Translation: CDO45061.1.
PIRiS11234.
RefSeqiNP_857426.1. NC_002945.3.
WP_003420544.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO45061; CDO45061; Mb3789.
GeneIDi1093295.
KEGGimbo:Mb3789.
PATRICi18010045. VBIMycBov88188_4145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15803 Genomic DNA. Translation: CAA33802.1.
BX248333 Genomic DNA. Translation: CDO45061.1.
PIRiS11234.
RefSeqiNP_857426.1. NC_002945.3.
WP_003420544.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP0A5J1.
SMRiP0A5J1. Positions 49-158.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO45061; CDO45061; Mb3789.
GeneIDi1093295.
KEGGimbo:Mb3789.
PATRICi18010045. VBIMycBov88188_4145.

Phylogenomic databases

HOGENOMiHOG000042299.
KOiK14953.
OMAiNKPFEIE.
OrthoDBiEOG6F29BX.

Family and domain databases

InterProiIPR008691. LpqH.
[Graphical view]
PfamiPF05481. Myco_19_kDa. 1 hit.
[Graphical view]
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the gene for the '19 kDa' antigen of Mycobacterium bovis."
    Collins M., Patki A., Wall S., Nolan A., Goodger J., Woodward M., Dale J.
    J. Gen. Microbiol. 136:1429-1436(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Isolate 381/79.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiLPQH_MYCBO
AccessioniPrimary (citable) accession number: P0A5J1
Secondary accession number(s): P11572, X2BQ19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: January 20, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.