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Reviewed, UniProtKB/Swiss-Prot P0A5H9 (GGPPS_MYCBO)

Last modified February 9, 2010. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Probable geranylgeranyl pyrophosphate synthetase
      Short name=GGPP synthetase
      Short name=GGPPSase
Alternative name(s):
    Geranylgeranyl diphosphate synthase
Including the following 3 domains:
    1- Recommended name:
            Dimethylallyltranstransferase
              EC=2.5.1.1
    2- Recommended name:
            Geranyltranstransferase
              EC=2.5.1.10
    3- Recommended name:
            Farnesyltranstransferase
              EC=2.5.1.29
Gene names
Ordered Locus Names: Mb3431c
OrganismMycobacterium bovis [Complete proteome] [HAMAP]
Taxonomic identifier1765 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

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Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids.

Catalytic activity

Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.

Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate.

Trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.

Cofactor

Binds 3 magnesium ions per subunit By similarity.

Pathway

Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.

Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.

Isoprenoid biosynthesis; geranylgeranyl diphosphate biosynthesis; geranylgeranyl diphosphate from farnesyl diphosphate and isopentenyl diphosphate: step 1/1.

Sequence similarities

Belongs to the FPP/GGPP synthetase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Probable geranylgeranyl pyrophosphate synthetase
PRO_0000123969

Sites

Metal binding1121Magnesium 1 By similarity
Metal binding1121Magnesium 2 By similarity
Metal binding1161Magnesium 1 By similarity
Metal binding1161Magnesium 2 By similarity
Metal binding2421Magnesium 3 By similarity
Binding site731Isopentenyl diphosphate By similarity
Binding site761Isopentenyl diphosphate By similarity
Binding site1051Isopentenyl diphosphate By similarity
Binding site1211Dimethylallyl diphosphate By similarity
Binding site1221Isopentenyl diphosphate By similarity
Binding site2011Dimethylallyl diphosphate By similarity
Binding site2021Dimethylallyl diphosphate By similarity
Binding site2391Dimethylallyl diphosphate By similarity
Binding site2561Dimethylallyl diphosphate By similarity
Binding site2661Dimethylallyl diphosphate By similarity

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Sequences

Sequence LengthMass (Da)Tools
P0A5H9-1 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: F59F229B19432E6E

FASTA35938,852
        10         20         30         40         50         60 
MRGTDEKYGL PPQPDSDRMT RRTLPVLGLA HELITPTLRQ MADRLDPHMR PVVSYHLGWS 

        70         80         90        100        110        120 
DERGRPVNNN CGKAIRPALV FVAAEAAGAD PHSAIPGAVS VELVHNFSLV HDDLMDRDEH 

       130        140        150        160        170        180 
RRHRPTVWAL WGDAMALLAG DAMLSLAHEV LLDCDSPHVG AALRAISEAT RELIRGQAAD 

       190        200        210        220        230        240 
TAFESRTDVA LDECLKMAEG KTAALMAASA EVGALLAGAP RSVREALVAY GRHIGLAFQL 

       250        260        270        280        290        300 
VDDLLGIWGR PEITGKPVYS DLRSRKKTLP VTWTVAHGGS AGRRLAAWLV DETGSQTASD 

       310        320        330        340        350 
DELAAVAELI ECGGGRRWAS AEARRHVTQG IDMVARIGIP DRPAAELQDL AHYIVDRQA

« Hide

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX248346 Genomic DNA. Translation: CAD95619.1.
RefSeqNP_857072.1.

3D structure databases

SMRP0A5H9. Positions 32-358.
ModBaseSearch...

Genome annotation databases

GeneID1090991.
KEGGmbo:Mb3431c.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG732667.
OMARMAPLES.

Enzyme and pathway databases

BioCycMBOV233413:MB3431C-MONOMER.
BRENDA2.5.1.1. 3091.
2.5.1.10. 3091.
2.5.1.29. 3091.

Family and domain databases

InterProIPR000092. Polyprenyl_synt.
IPR017446. Polyprenyl_synth-rel.
IPR008949. Terpenoid_synth.
[Graphical view]
Gene3DG3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
PANTHERPTHR12001. Polyprenyl_synt. 1 hit.
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
PROSITEPS00723. POLYPRENYL_SYNTHET_1. 1 hit.
PS00444. POLYPRENYL_SYNTHET_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameGGPPS_MYCBO
AccessionPrimary (citable) accession number: P0A5H9
Secondary accession number(s): Q50727
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: February 9, 2010
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents