P0A5H9 (GGPPS_MYCBO) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 45.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Probable geranylgeranyl pyrophosphate synthase Short name=GGPP synthase Short name=GGPPSase | ||
| Gene names |
| ||
| Organism | Mycobacterium bovis [Complete proteome] [HAMAP] | ||
| Taxonomic identifier | 1765 [NCBI] | ||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 359 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. |
| Catalytic activity | Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate. (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate. |
| Cofactor | Binds 3 magnesium ions per subunit By similarity. |
| Pathway | |
| Sequence similarities | Belongs to the FPP/GGPP synthase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Isoprene biosynthesis Lipid synthesis |
| Ligand | Magnesium Metal-binding |
| Molecular function | Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC farnesyltranstransferase activityInferred from electronic annotation. Source: EC geranyltranstransferase activityInferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 359 | 359 | Probable geranylgeranyl pyrophosphate synthase | PRO_0000123969 | |||||
Sites | |||||||||
| Metal binding | 112 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 112 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 116 | 1 | Magnesium 1 By similarity | ||||||
| Metal binding | 116 | 1 | Magnesium 2 By similarity | ||||||
| Metal binding | 242 | 1 | Magnesium 3 By similarity | ||||||
| Binding site | 73 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 76 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 105 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 121 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 122 | 1 | Isopentenyl diphosphate By similarity | ||||||
| Binding site | 201 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 202 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 239 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 256 | 1 | Dimethylallyl diphosphate By similarity | ||||||
| Binding site | 266 | 1 | Dimethylallyl diphosphate By similarity | ||||||
Sequences
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References
| [1] | "The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. Hewinson R.G.Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX248346 Genomic DNA. Translation: CAD95619.1. |
| RefSeq | NP_857072.1. NC_002945.3. |
3D structure databases | |
| ProteinModelPortal | P0A5H9. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBMYCT00000016735; EBMYCP00000016570; EBMYCG00000016730. |
| GeneID | 1090991. |
| GenomeReviews | Gene locus Mb3431c in contig BX248333_GR. |
| KEGG | mbo:Mb3431c. |
| PATRIC | 18009276. VBIMycBov88188_3766. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| GeneTree | EBGT00050000015046. |
| HOGENOM | HBG732667. |
| OMA | RMAPLES. |
| ProtClustDB | CLSK799990. |
Enzyme and pathway databases | |
| BioCyc | MBOV233413:MB3431C-MONOMER. |
Family and domain databases | |
| InterPro | IPR000092. Polyprenyl_synt. IPR017446. Polyprenyl_synth-rel. IPR008949. Terpenoid_synth. [Graphical view] |
| Gene3D | G3DSA:1.10.600.10. Terpenoid_synth. 1 hit. |
| KO | K13787. |
| PANTHER | PTHR12001. Polyprenyl_synt. 1 hit. |
| Pfam | PF00348. polyprenyl_synt. 1 hit. [Graphical view] |
| SUPFAM | SSF48576. Terpenoid_synth. 1 hit. |
| PROSITE | PS00723. POLYPRENYL_SYNTHASE_1. 1 hit. PS00444. POLYPRENYL_SYNTHASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | GGPPS_MYCBO | ||||||||
| Accession | Primary (citable) accession number: P0A5H9 Secondary accession number(s): Q50727 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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