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P0A5H5 (IF1_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Translation initiation factor IF-1
Gene names
Name:infA
Ordered Locus Names:Rv3462c, MT3568
ORF Names:MCB1222.32c, MTCY13E12.15c
OrganismMycobacterium tuberculosis [Reference proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length73 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

No specific function has so far been attributed to this initiation factor; however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 By similarity. HAMAP-Rule MF_00075

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the IF-1 family.

Contains 1 S1-like domain.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   Molecular functionInitiation factor
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processgrowth

Inferred from mutant phenotype PubMed 12657046. Source: MTBBASE

   Cellular_componentcell wall

Inferred from direct assay PubMed 20825248. Source: MTBBASE

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from direct assay PubMed 15525680. Source: MTBBASE

   Molecular_functiontranslation initiation factor activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 7372Translation initiation factor IF-1 HAMAP-Rule MF_00075
PRO_0000095828

Regions

Domain2 – 7372S1-like

Secondary structure

1 ............. 73
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0A5H5 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 70CEB2A79E874448

FASTA738,489
        10         20         30         40         50         60 
MAKKDGAIEV EGRVVEPLPN AMFRIELENG HKVLAHISGK MRQHYIRILP EDRVVVELSP 

        70 
YDLSRGRIVY RYK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842583 Genomic DNA. Translation: CAB08728.1.
AE000516 Genomic DNA. Translation: AAK47908.1.
AL123456 Genomic DNA. Translation: CCP46284.1.
PIRC70566.
RefSeqNP_217979.1. NC_000962.3.
NP_338094.1. NC_002755.2.
YP_006516951.1. NC_018143.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3I4OX-ray1.47A/B1-73[»]
ProteinModelPortalP0A5H5.
SMRP0A5H5. Positions 6-73.
ModBaseSearch...

Protein-protein interaction databases

STRING83332.Rv3462c.

Proteomic databases

PRIDEP0A5H5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK47908; AAK47908; MT3568.
GeneID13317069.
887325.
926629.
KEGGmtc:MT3568.
mtu:Rv3462c.
mtv:RVBD_3462c.
PATRIC18129575. VBIMycTub22151_3883.

Organism-specific databases

TubercuListRv3462c.

Phylogenomic databases

eggNOGCOG0361.
HOGENOMHOG000221323.
KOK02518.
OMAMRMNYIK.
ProtClustDBPRK00276.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
HAMAPMF_00075. IF-1.
InterProIPR012340. NA-bd_OB-fold.
IPR022967. RNA-binding_domain_S1.
IPR006196. RNA-binding_domain_S1_IF1.
IPR004368. TIF_IF1.
[Graphical view]
PfamPF01176. eIF-1a. 1 hit.
[Graphical view]
SMARTSM00316. S1. 1 hit.
[Graphical view]
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMsTIGR00008. infA. 1 hit.
PROSITEPS50832. S1_IF1_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP0A5H5.

Entry information

Entry nameIF1_MYCTU
AccessionPrimary (citable) accession number: P0A5H5
Secondary accession number(s): L0TCT8, P45957
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: January 23, 2007
Last modified: May 1, 2013
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Translation initiation factors

List of translation initiation factor entries

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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