P0A5C1 (Y037_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized MFS-type transporter Rv0037c/MT0042

Gene names

Ordered Locus Names:	Rv0037c, MT0042
ORF Names:	MTCY10H4.37c

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the major facilitator superfamily.
Sequence caution	The sequence AAK44265.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 441	441	Uncharacterized MFS-type transporter Rv0037c/MT0042		PRO_0000103654
Regions
	Transmembrane	68 – 88	21	Helical; Potential
	Transmembrane	110 – 130	21	Helical; Potential
	Transmembrane	131 – 151	21	Helical; Potential
	Transmembrane	164 – 184	21	Helical; Potential
	Transmembrane	194 – 214	21	Helical; Potential
	Transmembrane	229 – 246	18	Helical; Potential
	Transmembrane	260 – 280	21	Helical; Potential
	Transmembrane	287 – 307	21	Helical; Potential
	Transmembrane	337 – 357	21	Helical; Potential
	Transmembrane	384 – 404	21	Helical; Potential
	Transmembrane	412 – 432	21	Helical; Potential
Natural variations
	Natural variant	242	1	W → L in strain: CDC 1551 / Oshkosh.

Sequences

	Sequence		Length	Mass (Da)
	P0A5C1 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 461B7AF72F1BB027	FASTA	441	45,866
	10 20 30 40 50 60 MPRVEVGLVI HSRMHARAPV DVWRSVRSLP DFWRLLQVRV ASQFGDGLFQ AGLAGALLFN 70 80 90 100 110 120 PDRAADPMAI AGAFAVLFLP YSLLGPFAGA LMDRWDRRWV LVGANTGRLA LIAGVGTILA 130 140 150 160 170 180 VGAGDVPLLV GALVANGLAR FVASGLSAAL PHVVPREQVV TMNSVAIASG AVSAFLGANF 190 200 210 220 230 240 MLLPRWLLGS GDEGASAIVF LVAIPVSIAL LWSLRFGPRV LGPDDTERAI HGSAVYAVVT 250 260 270 280 290 300 GWLHGARTVV QLPTVAAGLS GLAAHRMVVG INSLLILLLV RHVTARAVGG LGTALLFFAA 310 320 330 340 350 360 TGLGAFLANV LTPTAIRRWG RYATANGALA AAATIQVAAA GLLVPVMVVC GFLLGVAGQV 370 380 390 400 410 420 VKLCADSAMQ MDVDDALRGH VFAVQDALFW VSYILSITVA AALIPEHGHA PVFVLFGSAI 430 440 YLAGLVVHTI VGRRGQPVIG R

References

[1]

"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.

[2]

"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842572 Genomic DNA. Translation: CAB02422.1. AE000516 Genomic DNA. Translation: AAK44265.1. Different initiation.
PIR	C70702.
RefSeq	NP_214551.1. NC_000962.2. NP_334451.1. NC_002755.2.
3D structure databases
ProteinModelPortal	P0A5C1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000001856; EBMYCP00000001856; EBMYCG00000001854. EBMYCT00000070138; EBMYCP00000068197; EBMYCG00000070133.
GeneID	887042. 922611.
GenomeReviews	Gene locus MT0042 in contig AE000516_GR. Gene locus Rv0037c in contig AL123456_GR.
KEGG	mtc:MT0042. mtu:Rv0037c.
PATRIC	18121819. VBIMycTub22151_0044.
TIGR	MT0042.
Organism-specific databases
TubercuList	Rv0037c.
Phylogenomic databases
GeneTree	EBGT00050000014798.
HOGENOM	HBG565047.
OMA	IGIGTHR.
ProtClustDB	CLSK871747.
Family and domain databases
InterPro	IPR011701. MFS. IPR016196. MFS_dom_general_subst_transpt. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Y037_MYCTU

Accession

Primary (citable) accession number: P0A5C1
Secondary accession number(s): P71607

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program