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P0A5B3 (HIS3_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosyl-AMP cyclohydrolase
Short name=PRA-CH
EC=3.5.4.19
Gene names
Name:hisI
Ordered Locus Names:Rv1606, MT1641.1
ORF Names:MTV046.04
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length115 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01021

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP MF_01021

Subcellular location

Cytoplasm By similarity HAMAP MF_01021.

Sequence similarities

Belongs to the PRA-CH family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Histidine biosynthesis
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processgrowth

Inferred from mutant phenotype. Source: MTBBASE

histidine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionphosphoribosyl-AMP cyclohydrolase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 115115Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01021
PRO_0000136486

Sequences

Sequence LengthMass (Da)Tools
P0A5B3 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 07519F1E5D4D6D83

FASTA11512,465
        10         20         30         40         50         60 
MTLDPKIAAR LKRNADGLVT AVVQERGSGD VLMVAWMNDE ALARTLQTRE ATYYSRSRAE 

        70         80         90        100        110 
QWVKGATSGH TQHVHSVRLD CDGDAVLLTV DQVGGACHTG DHSCFDAAVL LEPDD

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842577 Genomic DNA. Translation: CAB10717.2.
AE000516 Genomic DNA. Translation: AAK45910.1.
PIRE70819.
RefSeqNP_216638.2. NC_000962.2.
NP_336096.1. NC_002755.2.

3D structure databases

ProteinModelPortalP0A5B3.
SMRP0A5B3. Positions 10-108.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000000690; EBMYCP00000000690; EBMYCG00000000690.
EBMYCT00000071591; EBMYCP00000069650; EBMYCG00000071586.
GeneID886011.
924216.
GenomeReviewsGene locus MT1641.1 in contig AE000516_GR.
Gene locus Rv1606 in contig AL123456_GR.
KEGGmtc:MT1641.1.
mtu:Rv1606.
PATRIC18125372. VBIMycTub22151_1801.
TIGRMT1641.1.

Organism-specific databases

TubercuListRv1606.

Phylogenomic databases

GeneTreeEBGT00050000017128.
HOGENOMHBG294308.
OMAGACHVGY.
PhylomeDBP0A5B3.
ProtClustDBPRK00051.

Family and domain databases

HAMAPMF_01021. HisI.
[Tree]
InterProIPR002496. PRib_AMP_CycHydrolase.
[Graphical view]
KOK01496.
PfamPF01502. PRA-CH. 1 hit.
[Graphical view]
ProDomPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameHIS3_MYCTU
AccessionPrimary (citable) accession number: P0A5B3
Secondary accession number(s): O53909
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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