Skip Header

Contribute Send feedback
Read comments (?) or add your own

P0A5A8 (PPOX_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protoporphyrinogen oxidase
Short name=PPO
EC=1.3.3.4
Gene names
Name:hemY
Ordered Locus Names:Mb2696c
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex ›

Protein attributes

Sequence length452 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.

Catalytic activity

Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.

Cofactor

Binds 1 FAD per dimer By similarity.

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the protoporphyrinogen oxidase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionoxygen-dependent protoporphyrinogen oxidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 452452Protoporphyrinogen oxidase
PRO_0000135266

Regions

Nucleotide binding10 – 156FAD Potential

Sequences

Sequence LengthMass (Da)Tools
P0A5A8 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 6DFA1F57BEE2810F

FASTA45246,846
        10         20         30         40         50         60 
MTPRSYCVVG GGISGLTSAY RLRQAVGDDA TITLFEPADR LGGVLRTEHI GGQPMDLGAE 

        70         80         90        100        110        120 
AFVLRRPEMP ALLAELGLSD RQLASTGARP LIYSQQRLHP LPPQTVVGIP SSAGSMAGLV 

       130        140        150        160        170        180 
DDATLARIDA EAARPFTWQV GSDPAVADLV ADRFGDQVVA RSVDPLLSGV YAGSAATIGL 

       190        200        210        220        230        240 
RAAAPSVAAA LDRGATSVTD AVRQALPPGS GGPVFGALDG GYQVLLDGLV RRSRVHWVRA 

       250        260        270        280        290        300 
RVVQLERGWV LRDETGGRWQ ADAVILAVPA PRLARLVDGI APRTHAAARQ IVSASSAVVA 

       310        320        330        340        350        360 
LAVPGGTAFP HCSGVLVAGD ESPHAKAITL SSRKWGQRGD VALLRLSFGR FGDEPALTAS 

       370        380        390        400        410        420 
DDQLLAWAAD DLVTVFGVAV DPVDVRVRRW IEAMPQYGPG HADVVAELRA GLPPTLAVAG 

       430        440        450 
SYLDGIGVPA CVGAAGRAVT SVIEALDAQV AR

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX248343 Genomic DNA. Translation: CAD94881.1.
RefSeqNP_856342.1. NC_002945.3.

3D structure databases

ProteinModelPortalP0A5A8.
SMRP0A5A8. Positions 8-443.
ModBaseSearch...

Protein-protein interaction databases

STRING233413.Mb2696c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD94881; CAD94881; Mb2696c.
GeneID1091915.
KEGGmbo:Mb2696c.
PATRIC18007645. VBIMycBov88188_2955.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1232.
HOGENOMHOG000269479.
KOK00231.
OMASWPGKLR.
ProtClustDBPRK11883.

Enzyme and pathway databases

UniPathwayUPA00251; UER00324.

Family and domain databases

InterProIPR002937. Amino_oxidase.
IPR004572. Protoporphyrinogen_oxidase.
[Graphical view]
PfamPF01593. Amino_oxidase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00562. proto_IX_ox. 1 hit.
ProtoNetSearch...

Entry information

Entry namePPOX_MYCBO
AccessionPrimary (citable) accession number: P0A5A8
Secondary accession number(s): O53230
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents