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Protein

Glucose-6-phosphate 1-dehydrogenase 1

Gene

zwf1

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase 1 (zwf1), Glucose-6-phosphate 1-dehydrogenase 2 (zwf2)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd1)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei48NADPUniRule annotation1
Binding sitei141NADPUniRule annotation1
Binding sitei171SubstrateUniRule annotation1
Binding sitei175SubstrateUniRule annotation1
Binding sitei209SubstrateUniRule annotation1
Binding sitei228SubstrateUniRule annotation1
Active sitei233Proton acceptorUniRule annotation1
Binding sitei319SubstrateUniRule annotation1
Binding sitei324SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi88 – 89NADPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase 1UniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PD 1UniRule annotation
Gene namesi
Name:zwf1UniRule annotation
Synonyms:zwf
Ordered Locus Names:Mb1152
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681291 – 466Glucose-6-phosphate 1-dehydrogenase 1Add BLAST466

Structurei

3D structure databases

ProteinModelPortaliP0A587.
SMRiP0A587.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000046191.
KOiK00036.
OMAiGGICANL.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A587-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDGGGGASD LLVIFGITGD LARKMTFRAL YRLERHQLLD CPILGVASDD
60 70 80 90 100
MSVGQLVKWA RESIGRTEKI DDAVFDRLAG RLSYLHGDVT DSQLYDSLAE
110 120 130 140 150
LIGSACRPLY YLEMPPALFA PIVENLANVR LLERARVAVE KPFGHDLASA
160 170 180 190 200
LELNARLRAV LGEDQILRVD HFLGKQPVVE LEYLRFANQA LAELWDRNSI
210 220 230 240 250
SEIHITMAED FGVEDRGKFY DAVGALRDVV QNHLLQVLAL VTMEPPVGSS
260 270 280 290 300
ADDLNDKKAE VFRAMAPLDP DRCVRGQYLG YTEVAGVASD SATETYVALR
310 320 330 340 350
TEIDNWRWAG VPIFVRAGKE LPAKVTEVRL FLRRVPALAF LPNRRPAEPN
360 370 380 390 400
QIVLRIDPDP GMRLQISAHT DDSWRDIHLD SSFAVDLGEP IRPYERLLYA
410 420 430 440 450
GLVGDHQLFA REDSIEQTWR IVQPLLDNPG EIHRYDRGSW GPEAAQSLLR
460
GHRGWQSPWL PRGTDA
Length:466
Mass (Da):52,173
Last modified:March 15, 2005 - v1
Checksum:i536302013052A596
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42398.1.
RefSeqiNP_854808.1. NC_002945.3.
WP_003898735.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO42398; CDO42398; Mb1152.
GeneIDi1090448.
KEGGimbo:Mb1152.
PATRICi18004215. VBIMycBov88188_1260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42398.1.
RefSeqiNP_854808.1. NC_002945.3.
WP_003898735.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP0A587.
SMRiP0A587.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO42398; CDO42398; Mb1152.
GeneIDi1090448.
KEGGimbo:Mb1152.
PATRICi18004215. VBIMycBov88188_1260.

Phylogenomic databases

HOGENOMiHOG000046191.
KOiK00036.
OMAiGGICANL.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD. 1 hit.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PD1_MYCBO
AccessioniPrimary (citable) accession number: P0A587
Secondary accession number(s): O06573, X2BH05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.