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P0A587

- G6PD1_MYCBO

UniProt

P0A587 - G6PD1_MYCBO

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Protein

Glucose-6-phosphate 1-dehydrogenase 1

Gene

zwf1

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481NADPUniRule annotation
Binding sitei141 – 1411NADPUniRule annotation
Binding sitei171 – 1711SubstrateUniRule annotation
Binding sitei175 – 1751SubstrateUniRule annotation
Binding sitei209 – 2091SubstrateUniRule annotation
Binding sitei228 – 2281SubstrateUniRule annotation
Active sitei233 – 2331Proton acceptorUniRule annotation
Binding sitei319 – 3191SubstrateUniRule annotation
Binding sitei324 – 3241SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi88 – 892NADPUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase 1UniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PD 1UniRule annotation
Gene namesi
Name:zwf1UniRule annotation
Synonyms:zwf
Ordered Locus Names:Mb1152
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Glucose-6-phosphate 1-dehydrogenase 1PRO_0000068129Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb1152.

Structurei

3D structure databases

ProteinModelPortaliP0A587.
SMRiP0A587. Positions 9-462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiETWRIVQ.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A587 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVDGGGGASD LLVIFGITGD LARKMTFRAL YRLERHQLLD CPILGVASDD
60 70 80 90 100
MSVGQLVKWA RESIGRTEKI DDAVFDRLAG RLSYLHGDVT DSQLYDSLAE
110 120 130 140 150
LIGSACRPLY YLEMPPALFA PIVENLANVR LLERARVAVE KPFGHDLASA
160 170 180 190 200
LELNARLRAV LGEDQILRVD HFLGKQPVVE LEYLRFANQA LAELWDRNSI
210 220 230 240 250
SEIHITMAED FGVEDRGKFY DAVGALRDVV QNHLLQVLAL VTMEPPVGSS
260 270 280 290 300
ADDLNDKKAE VFRAMAPLDP DRCVRGQYLG YTEVAGVASD SATETYVALR
310 320 330 340 350
TEIDNWRWAG VPIFVRAGKE LPAKVTEVRL FLRRVPALAF LPNRRPAEPN
360 370 380 390 400
QIVLRIDPDP GMRLQISAHT DDSWRDIHLD SSFAVDLGEP IRPYERLLYA
410 420 430 440 450
GLVGDHQLFA REDSIEQTWR IVQPLLDNPG EIHRYDRGSW GPEAAQSLLR
460
GHRGWQSPWL PRGTDA
Length:466
Mass (Da):52,173
Last modified:March 15, 2005 - v1
Checksum:i536302013052A596
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO42398.1.
RefSeqiNP_854808.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD94013; CAD94013; Mb1152.
GeneIDi1090448.
KEGGimbo:Mb1152.
PATRICi18004215. VBIMycBov88188_1260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO42398.1 .
RefSeqi NP_854808.1. NC_002945.3.

3D structure databases

ProteinModelPortali P0A587.
SMRi P0A587. Positions 9-462.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb1152.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD94013 ; CAD94013 ; Mb1152 .
GeneIDi 1090448.
KEGGi mbo:Mb1152.
PATRICi 18004215. VBIMycBov88188_1260.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046191.
KOi K00036.
OMAi ETWRIVQ.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiG6PD1_MYCBO
AccessioniPrimary (citable) accession number: P0A587
Secondary accession number(s): O06573, X2BH05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 1, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3