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Protein

Glucose-6-phosphate 1-dehydrogenase 1

Gene

zwf1

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase 1 (zwf1), Glucose-6-phosphate 1-dehydrogenase 2 (zwf2)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd1)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei48NADPUniRule annotation1
Binding sitei141NADPUniRule annotation1
Binding sitei171SubstrateUniRule annotation1
Binding sitei175SubstrateUniRule annotation1
Binding sitei209SubstrateUniRule annotation1
Binding sitei228SubstrateUniRule annotation1
Active sitei233Proton acceptorUniRule annotation1
Binding sitei319SubstrateUniRule annotation1
Binding sitei324SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi88 – 89NADPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandNADP

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-1188-MONOMER
UniPathwayiUPA00115; UER00408

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase 1UniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PD 1UniRule annotation
Gene namesi
Name:zwf1UniRule annotation
Synonyms:zwf
Ordered Locus Names:BQ2027_MB1152
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681291 – 466Glucose-6-phosphate 1-dehydrogenase 1Add BLAST466

Structurei

3D structure databases

ProteinModelPortaliP0A587
SMRiP0A587
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000046191
OMAiFQLLAMV

Family and domain databases

HAMAPiMF_00966 G6PD, 1 hit
InterProiView protein in InterPro
IPR001282 G6P_DH
IPR019796 G6P_DH_AS
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PIRSFiPIRSF000110 G6PD, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00871 zwf, 1 hit
PROSITEiView protein in PROSITE
PS00069 G6P_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

P0A587-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDGGGGASD LLVIFGITGD LARKMTFRAL YRLERHQLLD CPILGVASDD
60 70 80 90 100
MSVGQLVKWA RESIGRTEKI DDAVFDRLAG RLSYLHGDVT DSQLYDSLAE
110 120 130 140 150
LIGSACRPLY YLEMPPALFA PIVENLANVR LLERARVAVE KPFGHDLASA
160 170 180 190 200
LELNARLRAV LGEDQILRVD HFLGKQPVVE LEYLRFANQA LAELWDRNSI
210 220 230 240 250
SEIHITMAED FGVEDRGKFY DAVGALRDVV QNHLLQVLAL VTMEPPVGSS
260 270 280 290 300
ADDLNDKKAE VFRAMAPLDP DRCVRGQYLG YTEVAGVASD SATETYVALR
310 320 330 340 350
TEIDNWRWAG VPIFVRAGKE LPAKVTEVRL FLRRVPALAF LPNRRPAEPN
360 370 380 390 400
QIVLRIDPDP GMRLQISAHT DDSWRDIHLD SSFAVDLGEP IRPYERLLYA
410 420 430 440 450
GLVGDHQLFA REDSIEQTWR IVQPLLDNPG EIHRYDRGSW GPEAAQSLLR
460
GHRGWQSPWL PRGTDA
Length:466
Mass (Da):52,173
Last modified:March 15, 2005 - v1
Checksum:i536302013052A596
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIT99752.1
RefSeqiNP_854808.1, NC_002945.3
WP_003898735.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO42398; CDO42398; Mb1152
PATRICifig|233413.5.peg.1260

Similar proteinsi

Entry informationi

Entry nameiG6PD1_MYCBO
AccessioniPrimary (citable) accession number: P0A587
Secondary accession number(s): A0A1R3XZI2, O06573, X2BH05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 25, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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