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P0A586 (G6PD2_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable glucose-6-phosphate 1-dehydrogenase
Short name=G6PD
EC=1.1.1.49
Gene names
Name:zwf2
Synonyms:zwf
Ordered Locus Names:Rv1121, MT1153
ORF Names:MTCY22G8.10
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length466 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.

Sequence similarities

Belongs to the glucose-6-phosphate dehydrogenase family.

Caution

M.tuberculosis has two genes for zwf. This one is highly divergent.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processglucose metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentplasma membrane

Inferred from direct assay. Source: MTBBASE

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

glucose-6-phosphate dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 466466Probable glucose-6-phosphate 1-dehydrogenase
PRO_0000068128

Sites

Active site2331Proton acceptor By similarity
Binding site181NADP By similarity
Binding site481NADP By similarity
Binding site1711Substrate By similarity
Binding site1751Substrate By similarity
Binding site3241Substrate By similarity

Experimental info

Sequence conflict3171A → S in AAK45410. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P0A586 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 536302013052A596

FASTA46652,173
        10         20         30         40         50         60 
MVDGGGGASD LLVIFGITGD LARKMTFRAL YRLERHQLLD CPILGVASDD MSVGQLVKWA 

        70         80         90        100        110        120 
RESIGRTEKI DDAVFDRLAG RLSYLHGDVT DSQLYDSLAE LIGSACRPLY YLEMPPALFA 

       130        140        150        160        170        180 
PIVENLANVR LLERARVAVE KPFGHDLASA LELNARLRAV LGEDQILRVD HFLGKQPVVE 

       190        200        210        220        230        240 
LEYLRFANQA LAELWDRNSI SEIHITMAED FGVEDRGKFY DAVGALRDVV QNHLLQVLAL 

       250        260        270        280        290        300 
VTMEPPVGSS ADDLNDKKAE VFRAMAPLDP DRCVRGQYLG YTEVAGVASD SATETYVALR 

       310        320        330        340        350        360 
TEIDNWRWAG VPIFVRAGKE LPAKVTEVRL FLRRVPALAF LPNRRPAEPN QIVLRIDPDP 

       370        380        390        400        410        420 
GMRLQISAHT DDSWRDIHLD SSFAVDLGEP IRPYERLLYA GLVGDHQLFA REDSIEQTWR 

       430        440        450        460 
IVQPLLDNPG EIHRYDRGSW GPEAAQSLLR GHRGWQSPWL PRGTDA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842575 Genomic DNA. Translation: CAE55363.1.
AE000516 Genomic DNA. Translation: AAK45410.1.
PIRB70538.
RefSeqNP_335596.1. NC_002755.2.
YP_177789.1. NC_000962.2.

3D structure databases

ProteinModelPortalP0A586.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000003059; EBMYCP00000003059; EBMYCG00000003057.
EBMYCT00000069674; EBMYCP00000067733; EBMYCG00000069669.
GeneID885817.
924943.
GenomeReviewsGene locus MT1153 in contig AE000516_GR.
Gene locus Rv1121 in contig AL123456_GR.
KEGGmtc:MT1153.
mtu:Rv1121.
PATRIC18124296. VBIMycTub22151_1268.
TIGRMT1153.

Organism-specific databases

TubercuListRv1121.

Phylogenomic databases

GeneTreeEBGT00050000015853.
HOGENOMHBG322449.
OMAWSESIDD.
PhylomeDBP0A586.
ProtClustDBPRK12853.

Family and domain databases

InterProIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00036.
PANTHERPTHR23429. G6PDH. 1 hit.
PfamPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFPIRSF000110. G6PD. 1 hit.
PRINTSPR00079. G6PDHDRGNASE.
TIGRFAMsTIGR00871. Zwf. 1 hit.
PROSITEPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PD2_MYCTU
AccessionPrimary (citable) accession number: P0A586
Secondary accession number(s): O06573
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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