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Protein

Glucose-6-phosphate 1-dehydrogenase 2

Gene

zwf2

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase 1 (zwf1), Glucose-6-phosphate 1-dehydrogenase 2 (zwf2)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd1)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei69NADPUniRule annotation1
Binding sitei176NADPUniRule annotation1
Binding sitei206SubstrateUniRule annotation1
Binding sitei210SubstrateUniRule annotation1
Binding sitei244SubstrateUniRule annotation1
Binding sitei263SubstrateUniRule annotation1
Active sitei268Proton acceptorUniRule annotation1
Binding sitei366SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandNADP

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-1538-MONOMER
UniPathwayiUPA00115; UER00408

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase 2UniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PD 2UniRule annotation
Gene namesi
Name:zwf2UniRule annotation
Synonyms:zwf
Ordered Locus Names:BQ2027_MB1482C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681271 – 514Glucose-6-phosphate 1-dehydrogenase 2Add BLAST514

Proteomic databases

PRIDEiP0A585

Structurei

3D structure databases

ProteinModelPortaliP0A585
SMRiP0A585
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000046191
OMAiVEICVYE

Family and domain databases

HAMAPiMF_00966 G6PD, 1 hit
InterProiView protein in InterPro
IPR001282 G6P_DH
IPR019796 G6P_DH_AS
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PIRSFiPIRSF000110 G6PD, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00871 zwf, 1 hit
PROSITEiView protein in PROSITE
PS00069 G6P_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

P0A585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPAHAAASW RNPLRDKRDK RLPRIAGPCG MVIFGVTGDL ARKKVMPAVY
60 70 80 90 100
DLANRGLLPP TFSLVGFARR DWSTQDFGQV VYNAVQEHCR TPFRQQNWDR
110 120 130 140 150
LAEGFRFVPG TFDDDDAFAQ LAETLEKLDA ERGTGGNHAF YLAIPPKSFP
160 170 180 190 200
VVCEQLHKSG LARPQGDRWS RVVIEKPFGH DLASARELNK AVNAVFPEEA
210 220 230 240 250
VFRIDHYLGK ETVQNILALR FANQLFDPIW NAHYVDHVQI TMAEDIGLGG
260 270 280 290 300
RAGYYDGIGA ARDVIQNHLM QLLALTAMEE PVSFHPAALQ AEKIKVLSAT
310 320 330 340 350
RLAEPLDQTT SRGQYAAGWQ GGEKVVGLLD EEGFAEDSTT ETFAAITLEV
360 370 380 390 400
DTRRWAGVPF YLRTGKRLGR RVTEIALVFR RAPHLPFDAT MTDELGTNAM
410 420 430 440 450
VIRVQPDEGV TLRFGSKVPG TAMEVRDVNM DFSYGSAFAE DSPEAYERLI
460 470 480 490 500
LDVLLGEPSL FPVNAEVELA WEILDPALEH WAAHGTPDAY EAGTWGPESS
510
LEMLRRTGRE WRRP
Length:514
Mass (Da):57,343
Last modified:March 15, 2005 - v1
Checksum:i22A9CCEDC9AB062F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIU00085.1
RefSeqiNP_855134.1, NC_002945.3
WP_003407443.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO42730; CDO42730; Mb1482c
PATRICifig|233413.5.peg.1621

Similar proteinsi

Entry informationi

Entry nameiG6PD2_MYCBO
AccessioniPrimary (citable) accession number: P0A585
Secondary accession number(s): A0A1R3XYD7, O08407, X2BID3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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