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P0A585

- G6PD2_MYCBO

UniProt

P0A585 - G6PD2_MYCBO

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Protein

Glucose-6-phosphate 1-dehydrogenase 2

Gene

zwf2

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 691NADPUniRule annotation
Binding sitei176 – 1761NADPUniRule annotation
Binding sitei206 – 2061SubstrateUniRule annotation
Binding sitei210 – 2101SubstrateUniRule annotation
Binding sitei244 – 2441SubstrateUniRule annotation
Binding sitei263 – 2631SubstrateUniRule annotation
Active sitei268 – 2681Proton acceptorUniRule annotation
Binding sitei366 – 3661SubstrateUniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NADP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase 2UniRule annotation (EC:1.1.1.49UniRule annotation)
Short name:
G6PD 2UniRule annotation
Gene namesi
Name:zwf2UniRule annotation
Synonyms:zwf
Ordered Locus Names:Mb1482c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Glucose-6-phosphate 1-dehydrogenase 2PRO_0000068127Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb1482c.

Structurei

3D structure databases

ProteinModelPortaliP0A585.
SMRiP0A585. Positions 32-511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiHAFTESS.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A585-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPAHAAASW RNPLRDKRDK RLPRIAGPCG MVIFGVTGDL ARKKVMPAVY
60 70 80 90 100
DLANRGLLPP TFSLVGFARR DWSTQDFGQV VYNAVQEHCR TPFRQQNWDR
110 120 130 140 150
LAEGFRFVPG TFDDDDAFAQ LAETLEKLDA ERGTGGNHAF YLAIPPKSFP
160 170 180 190 200
VVCEQLHKSG LARPQGDRWS RVVIEKPFGH DLASARELNK AVNAVFPEEA
210 220 230 240 250
VFRIDHYLGK ETVQNILALR FANQLFDPIW NAHYVDHVQI TMAEDIGLGG
260 270 280 290 300
RAGYYDGIGA ARDVIQNHLM QLLALTAMEE PVSFHPAALQ AEKIKVLSAT
310 320 330 340 350
RLAEPLDQTT SRGQYAAGWQ GGEKVVGLLD EEGFAEDSTT ETFAAITLEV
360 370 380 390 400
DTRRWAGVPF YLRTGKRLGR RVTEIALVFR RAPHLPFDAT MTDELGTNAM
410 420 430 440 450
VIRVQPDEGV TLRFGSKVPG TAMEVRDVNM DFSYGSAFAE DSPEAYERLI
460 470 480 490 500
LDVLLGEPSL FPVNAEVELA WEILDPALEH WAAHGTPDAY EAGTWGPESS
510
LEMLRRTGRE WRRP
Length:514
Mass (Da):57,343
Last modified:March 15, 2005 - v1
Checksum:i22A9CCEDC9AB062F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42730.1.
RefSeqiNP_855134.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD96149; CAD96149; Mb1482c.
GeneIDi1092339.
KEGGimbo:Mb1482c.
PATRICi18004948. VBIMycBov88188_1621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42730.1 .
RefSeqi NP_855134.1. NC_002945.3.

3D structure databases

ProteinModelPortali P0A585.
SMRi P0A585. Positions 32-511.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb1482c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD96149 ; CAD96149 ; Mb1482c .
GeneIDi 1092339.
KEGGi mbo:Mb1482c.
PATRICi 18004948. VBIMycBov88188_1621.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046191.
KOi K00036.
OMAi HAFTESS.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiG6PD2_MYCBO
AccessioniPrimary (citable) accession number: P0A585
Secondary accession number(s): O08407, X2BID3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3