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P0A585

- G6PD2_MYCBO

UniProt

P0A585 - G6PD2_MYCBO

Protein

Glucose-6-phosphate 1-dehydrogenase 2

Gene

zwf2

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.UniRule annotation

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei69 – 691NADPUniRule annotation
    Binding sitei176 – 1761NADPUniRule annotation
    Binding sitei206 – 2061SubstrateUniRule annotation
    Binding sitei210 – 2101SubstrateUniRule annotation
    Binding sitei244 – 2441SubstrateUniRule annotation
    Binding sitei263 – 2631SubstrateUniRule annotation
    Active sitei268 – 2681Proton acceptorUniRule annotation
    Binding sitei366 – 3661SubstrateUniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. NADP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenase 2UniRule annotation (EC:1.1.1.49UniRule annotation)
    Short name:
    G6PD 2UniRule annotation
    Gene namesi
    Name:zwf2UniRule annotation
    Synonyms:zwf
    Ordered Locus Names:Mb1482c
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 514514Glucose-6-phosphate 1-dehydrogenase 2PRO_0000068127Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi233413.Mb1482c.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A585.
    SMRiP0A585. Positions 32-511.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0364.
    HOGENOMiHOG000046191.
    KOiK00036.
    OMAiHAFTESS.
    OrthoDBiEOG61308Z.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A585-1 [UniParc]FASTAAdd to Basket

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    MKPAHAAASW RNPLRDKRDK RLPRIAGPCG MVIFGVTGDL ARKKVMPAVY    50
    DLANRGLLPP TFSLVGFARR DWSTQDFGQV VYNAVQEHCR TPFRQQNWDR 100
    LAEGFRFVPG TFDDDDAFAQ LAETLEKLDA ERGTGGNHAF YLAIPPKSFP 150
    VVCEQLHKSG LARPQGDRWS RVVIEKPFGH DLASARELNK AVNAVFPEEA 200
    VFRIDHYLGK ETVQNILALR FANQLFDPIW NAHYVDHVQI TMAEDIGLGG 250
    RAGYYDGIGA ARDVIQNHLM QLLALTAMEE PVSFHPAALQ AEKIKVLSAT 300
    RLAEPLDQTT SRGQYAAGWQ GGEKVVGLLD EEGFAEDSTT ETFAAITLEV 350
    DTRRWAGVPF YLRTGKRLGR RVTEIALVFR RAPHLPFDAT MTDELGTNAM 400
    VIRVQPDEGV TLRFGSKVPG TAMEVRDVNM DFSYGSAFAE DSPEAYERLI 450
    LDVLLGEPSL FPVNAEVELA WEILDPALEH WAAHGTPDAY EAGTWGPESS 500
    LEMLRRTGRE WRRP 514
    Length:514
    Mass (Da):57,343
    Last modified:March 15, 2005 - v1
    Checksum:i22A9CCEDC9AB062F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO42730.1.
    RefSeqiNP_855134.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD96149; CAD96149; Mb1482c.
    GeneIDi1092339.
    KEGGimbo:Mb1482c.
    PATRICi18004948. VBIMycBov88188_1621.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO42730.1 .
    RefSeqi NP_855134.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali P0A585.
    SMRi P0A585. Positions 32-511.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb1482c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD96149 ; CAD96149 ; Mb1482c .
    GeneIDi 1092339.
    KEGGi mbo:Mb1482c.
    PATRICi 18004948. VBIMycBov88188_1621.

    Phylogenomic databases

    eggNOGi COG0364.
    HOGENOMi HOG000046191.
    KOi K00036.
    OMAi HAFTESS.
    OrthoDBi EOG61308Z.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiG6PD2_MYCBO
    AccessioniPrimary (citable) accession number: P0A585
    Secondary accession number(s): O08407, X2BID3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3