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P0A585

- G6PD2_MYCBO

UniProt

P0A585 - G6PD2_MYCBO

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Protein
Glucose-6-phosphate 1-dehydrogenase 2
Gene
zwf2, zwf, Mb1482c
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone By similarity.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 691NADP By similarity
Binding sitei176 – 1761NADP By similarity
Binding sitei206 – 2061Substrate By similarity
Binding sitei210 – 2101Substrate By similarity
Binding sitei244 – 2441Substrate By similarity
Binding sitei263 – 2631Substrate By similarity
Active sitei268 – 2681Proton acceptor By similarity
Binding sitei366 – 3661Substrate By similarity

GO - Molecular functioni

  1. NADP binding Source: UniProtKB-HAMAP
  2. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase 2 (EC:1.1.1.49)
Short name:
G6PD 2
Gene namesi
Name:zwf2
Synonyms:zwf
Ordered Locus Names:Mb1482c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Glucose-6-phosphate 1-dehydrogenase 2UniRule annotation
PRO_0000068127Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi233413.Mb1482c.

Structurei

3D structure databases

ProteinModelPortaliP0A585.
SMRiP0A585. Positions 32-511.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046191.
KOiK00036.
OMAiHAFTESS.
OrthoDBiEOG61308Z.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A585-1 [UniParc]FASTAAdd to Basket

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MKPAHAAASW RNPLRDKRDK RLPRIAGPCG MVIFGVTGDL ARKKVMPAVY    50
DLANRGLLPP TFSLVGFARR DWSTQDFGQV VYNAVQEHCR TPFRQQNWDR 100
LAEGFRFVPG TFDDDDAFAQ LAETLEKLDA ERGTGGNHAF YLAIPPKSFP 150
VVCEQLHKSG LARPQGDRWS RVVIEKPFGH DLASARELNK AVNAVFPEEA 200
VFRIDHYLGK ETVQNILALR FANQLFDPIW NAHYVDHVQI TMAEDIGLGG 250
RAGYYDGIGA ARDVIQNHLM QLLALTAMEE PVSFHPAALQ AEKIKVLSAT 300
RLAEPLDQTT SRGQYAAGWQ GGEKVVGLLD EEGFAEDSTT ETFAAITLEV 350
DTRRWAGVPF YLRTGKRLGR RVTEIALVFR RAPHLPFDAT MTDELGTNAM 400
VIRVQPDEGV TLRFGSKVPG TAMEVRDVNM DFSYGSAFAE DSPEAYERLI 450
LDVLLGEPSL FPVNAEVELA WEILDPALEH WAAHGTPDAY EAGTWGPESS 500
LEMLRRTGRE WRRP 514
Length:514
Mass (Da):57,343
Last modified:March 15, 2005 - v1
Checksum:i22A9CCEDC9AB062F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO42730.1.
RefSeqiNP_855134.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD96149; CAD96149; Mb1482c.
GeneIDi1092339.
KEGGimbo:Mb1482c.
PATRICi18004948. VBIMycBov88188_1621.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO42730.1 .
RefSeqi NP_855134.1. NC_002945.3.

3D structure databases

ProteinModelPortali P0A585.
SMRi P0A585. Positions 32-511.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb1482c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD96149 ; CAD96149 ; Mb1482c .
GeneIDi 1092339.
KEGGi mbo:Mb1482c.
PATRICi 18004948. VBIMycBov88188_1621.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046191.
KOi K00036.
OMAi HAFTESS.
OrthoDBi EOG61308Z.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiG6PD2_MYCBO
AccessioniPrimary (citable) accession number: P0A585
Secondary accession number(s): O08407, X2BID3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 11, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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