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P0A579

- DHPS1_MYCBO

UniProt

P0A579 - DHPS1_MYCBO

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Protein

Dihydropteroate synthase 1

Gene

folP1

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide (By similarity).By similarity

Catalytic activityi

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactori

Mg2+By similarityNote: Binds 1 Mg(2+) ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131MagnesiumBy similarity
Binding sitei21 – 211SubstrateBy similarity
Binding sitei86 – 861SubstrateBy similarity
Binding sitei105 – 1051SubstrateBy similarity
Binding sitei177 – 1771SubstrateBy similarity
Binding sitei213 – 2131SubstrateBy similarity
Binding sitei253 – 2531SubstrateBy similarity
Binding sitei255 – 2551SubstrateBy similarity

GO - Molecular functioni

  1. dihydropteroate synthase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. folic acid biosynthetic process Source: UniProtKB-KW
  2. response to antibiotic Source: UniProtKB-KW
  3. tetrahydrofolate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Antibiotic resistance, Folate biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00077; UER00156.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropteroate synthase 1 (EC:2.5.1.15)
Short name:
DHPS 1
Alternative name(s):
Dihydropteroate pyrophosphorylase 1
Gene namesi
Name:folP1
Ordered Locus Names:Mb3638c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Dihydropteroate synthase 1PRO_0000168211Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi233413.Mb3638c.

Structurei

3D structure databases

ProteinModelPortaliP0A579.
SMRiP0A579. Positions 5-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 265265Pterin-bindingPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 542Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the DHPS family.Curated
Contains 1 pterin-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0294.
HOGENOMiHOG000217509.
KOiK00796.
OMAiGRWFDTT.
OrthoDBiEOG67T5P5.

Family and domain databases

Gene3Di3.20.20.20. 1 hit.
InterProiIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamiPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMiSSF51717. SSF51717. 1 hit.
TIGRFAMsiTIGR01496. DHPS. 1 hit.
PROSITEiPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A579-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSPAPVQVMG VLNVTDDSFS DGGCYLDLDD AVKHGLAMAA AGAGIVDVGG
60 70 80 90 100
ESSRPGATRV DPAVETSRVI PVVKELAAQG ITVSIDTMRA DVARAALQNG
110 120 130 140 150
AQMVNDVSGG RADPAMGPLL AEADVPWVLM HWRAVSADTP HVPVRYGNVV
160 170 180 190 200
AEVRADLLAS VADAVAAGVD PARLVLDPGL GFAKTAQHNW AILHALPELV
210 220 230 240 250
ATGIPVLVGA SRKRFLGALL AGPDGVMRPT DGRDTATAVI SALAALHGAW
260 270 280
GVRVHDVRAS VDAIKVVEAW MGAERIERDG
Length:280
Mass (Da):28,843
Last modified:March 15, 2005 - v1
Checksum:i737AB6DF12C51C8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44909.1.
RefSeqiNP_857277.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD95824; CAD95824; Mb3638c.
GeneIDi1093352.
KEGGimbo:Mb3638c.
PATRICi18009713. VBIMycBov88188_3984.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO44909.1 .
RefSeqi NP_857277.1. NC_002945.3.

3D structure databases

ProteinModelPortali P0A579.
SMRi P0A579. Positions 5-274.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb3638c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD95824 ; CAD95824 ; Mb3638c .
GeneIDi 1093352.
KEGGi mbo:Mb3638c.
PATRICi 18009713. VBIMycBov88188_3984.

Phylogenomic databases

eggNOGi COG0294.
HOGENOMi HOG000217509.
KOi K00796.
OMAi GRWFDTT.
OrthoDBi EOG67T5P5.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00156 .

Family and domain databases

Gene3Di 3.20.20.20. 1 hit.
InterProi IPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view ]
Pfami PF00809. Pterin_bind. 1 hit.
[Graphical view ]
SUPFAMi SSF51717. SSF51717. 1 hit.
TIGRFAMsi TIGR01496. DHPS. 1 hit.
PROSITEi PS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiDHPS1_MYCBO
AccessioniPrimary (citable) accession number: P0A579
Secondary accession number(s): O06274, X2BNV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 26, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3