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P0A579 (DHPS1_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydropteroate synthase 1

Short name=DHPS 1
EC=2.5.1.15
Alternative name(s):
Dihydropteroate pyrophosphorylase 1
Gene names
Name:folP1
Ordered Locus Names:Mb3638c
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide By similarity.

Catalytic activity

(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate.

Cofactor

Binds 1 magnesium ion per subunit. Magnesium is required for activity, even if it interacts primarily with the substrate By similarity.

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the DHPS family.

Contains 1 pterin-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280Dihydropteroate synthase 1
PRO_0000168211

Regions

Domain1 – 265265Pterin-binding
Region53 – 542Substrate binding By similarity

Sites

Metal binding131Magnesium By similarity
Binding site211Substrate By similarity
Binding site861Substrate By similarity
Binding site1051Substrate By similarity
Binding site1771Substrate By similarity
Binding site2131Substrate By similarity
Binding site2531Substrate By similarity
Binding site2551Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A579 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 737AB6DF12C51C8C

FASTA28028,843
        10         20         30         40         50         60 
MSPAPVQVMG VLNVTDDSFS DGGCYLDLDD AVKHGLAMAA AGAGIVDVGG ESSRPGATRV 

        70         80         90        100        110        120 
DPAVETSRVI PVVKELAAQG ITVSIDTMRA DVARAALQNG AQMVNDVSGG RADPAMGPLL 

       130        140        150        160        170        180 
AEADVPWVLM HWRAVSADTP HVPVRYGNVV AEVRADLLAS VADAVAAGVD PARLVLDPGL 

       190        200        210        220        230        240 
GFAKTAQHNW AILHALPELV ATGIPVLVGA SRKRFLGALL AGPDGVMRPT DGRDTATAVI 

       250        260        270        280 
SALAALHGAW GVRVHDVRAS VDAIKVVEAW MGAERIERDG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248333 Genomic DNA. Translation: CDO44909.1.
RefSeqNP_857277.1. NC_002945.3.

3D structure databases

ProteinModelPortalP0A579.
SMRP0A579. Positions 5-274.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb3638c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD95824; CAD95824; Mb3638c.
GeneID1093352.
KEGGmbo:Mb3638c.
PATRIC18009713. VBIMycBov88188_3984.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0294.
HOGENOMHOG000217509.
KOK00796.
OMAGRWFDTT.
OrthoDBEOG67T5P5.

Enzyme and pathway databases

UniPathwayUPA00077; UER00156.

Family and domain databases

Gene3D3.20.20.20. 1 hit.
InterProIPR006390. DHP_synth.
IPR011005. Dihydropteroate_synth-like.
IPR000489. Pterin-binding.
[Graphical view]
PfamPF00809. Pterin_bind. 1 hit.
[Graphical view]
SUPFAMSSF51717. SSF51717. 1 hit.
TIGRFAMsTIGR01496. DHPS. 1 hit.
PROSITEPS00792. DHPS_1. 1 hit.
PS00793. DHPS_2. 1 hit.
PS50972. PTERIN_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHPS1_MYCBO
AccessionPrimary (citable) accession number: P0A579
Secondary accession number(s): O06274, X2BNV3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 11, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways