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Protein

DNA polymerase I

Gene

polA

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA damage, DNA repair, DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
Gene namesi
Name:polA
Ordered Locus Names:Mb1655
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012451 – 904DNA polymerase IAdd BLAST904

Interactioni

Subunit structurei

Single-chain monomer with multiple functions.

Structurei

3D structure databases

ProteinModelPortaliP0A551.
SMRiP0A551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated
Contains 1 3'-5' exonuclease domain.Curated
Contains 1 5'-3' exonuclease domain.Curated

Phylogenomic databases

HOGENOMiHOG000020997.
KOiK02335.
OMAiCFDTETT.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSiPR00868. DNAPOLI.
SMARTiSM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTTASAPSE DRAKPTLMLL DGNSLAFRAF YALPAENFKT RGGLTTNAVY
60 70 80 90 100
GFTAMLINLL RDEAPTHIAA AFDVSRQTFR LQRYPEYKAN RSSTPDEFAG
110 120 130 140 150
QIDITKEVLG ALGITVLSEP GFEADDLIAT LATQAENEGY RVLVVTGDRD
160 170 180 190 200
ALQLVSDDVT VLYPRKGVSE LTRFTPEAVV EKYGLTPRQY PDFAALRGDP
210 220 230 240 250
SDNLPGIPGV GEKTAAKWIA EYGSLRSLVD NVDAVRGKVG DALRANLASV
260 270 280 290 300
VRNRELTDLV RDVPLAQTPD TLRLQPWDRD HIHRLFDDLE FRVLRDRLFD
310 320 330 340 350
TLAAAGGPEV DEGFDVRGGA LAPGTVRQWL AEHAGDGRRA GLTVVGTHLP
360 370 380 390 400
HGGDATAMAV AAADGEGAYL DTATLTPDDD AALAAWLADP AKPKALHEAK
410 420 430 440 450
AAVHDLAGRG WTLEGVTSDT ALAAYLVRPG QRSFTLDDLS LRYLRRELRA
460 470 480 490 500
ETPQQQQLSL LDDDDTDAET IQTTILRARA VIDLADALDA ELARIDSTAL
510 520 530 540 550
LGEMELPVQR VLAKMESAGI AVDLPMLTEL QSQFGDQIRD AAEAAYGVIG
560 570 580 590 600
KQINLGSPKQ LQVVLFDELG MPKTKRTKTG YTTDADALQS LFDKTGHPFL
610 620 630 640 650
QHLLAHRDVT RLKVTVDGLL QAVAADGRIH TTFNQTIAAT GRLSSTEPNL
660 670 680 690 700
QNIPIRTDAG RRIRDAFVVG DGYAELMTAD YSQIEMRIMA HLSGDEGLIE
710 720 730 740 750
AFNTGEDLHS FVASRAFGVP IDEVTGELRR RVKAMSYGLA YGLSAYGLSQ
760 770 780 790 800
QLKISTEEAN EQMDAYFARF GGVRDYLRAV VERARKDGYT STVLGRRRYL
810 820 830 840 850
PELDSSNRQV REAAERAALN APIQGSAADI IKVAMIQVDK ALNEAQLASR
860 870 880 890 900
MLLQVHDELL FEIAPGERER VEALVRDKMG GAYPLDVPLE VSVGYGRSWD

AAAH
Length:904
Mass (Da):98,472
Last modified:March 15, 2005 - v1
Checksum:i1C8E560FE5F74323
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42904.1.
RefSeqiNP_855308.1. NC_002945.3.
WP_003408063.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO42904; CDO42904; Mb1655.
GeneIDi1092592.
KEGGimbo:Mb1655.
PATRICi18005319. VBIMycBov88188_1806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO42904.1.
RefSeqiNP_855308.1. NC_002945.3.
WP_003408063.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP0A551.
SMRiP0A551.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO42904; CDO42904; Mb1655.
GeneIDi1092592.
KEGGimbo:Mb1655.
PATRICi18005319. VBIMycBov88188_1806.

Phylogenomic databases

HOGENOMiHOG000020997.
KOiK02335.
OMAiCFDTETT.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.40.50.1010. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR020046. 5-3_exonucl_a-hlix_arch_N.
IPR020045. 5-3_exonuclease_C.
IPR002421. 5-3_exonuclease_N.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR008918. HhH2.
IPR029060. PIN_domain-like.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01367. 5_3_exonuc. 1 hit.
PF02739. 5_3_exonuc_N. 1 hit.
PF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSiPR00868. DNAPOLI.
SMARTiSM00474. 35EXOc. 1 hit.
SM00475. 53EXOc. 1 hit.
SM00279. HhH2. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF47807. SSF47807. 1 hit.
SSF53098. SSF53098. 1 hit.
SSF88723. SSF88723. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPO1_MYCBO
AccessioniPrimary (citable) accession number: P0A551
Secondary accession number(s): Q07700, X2BIE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.