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Protein

DNA polymerase I

Gene

polA

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-1714-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
Gene namesi
Name:polA
Ordered Locus Names:BQ2027_MB1655
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012451 – 904DNA polymerase IAdd BLAST904

Interactioni

Subunit structurei

Single-chain monomer with multiple functions.

Structurei

3D structure databases

ProteinModelPortaliP0A551
SMRiP0A551
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 2795'-3' exonucleaseSequence analysisAdd BLAST94
Domaini317 – 4933'-5' exonucleaseSequence analysisAdd BLAST177

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated

Phylogenomic databases

HOGENOMiHOG000020997
OMAiETGRVHT

Family and domain databases

CDDicd09898 H3TH_53EXO, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR002562 3'-5'_exonuclease_dom
IPR020046 5-3_exonucl_a-hlix_arch_N
IPR036279 5-3_exonuclease_C_sf
IPR002421 5-3_exonuclease_N
IPR019760 DNA-dir_DNA_pol_A_CS
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR020045 DNA_polI_H3TH
IPR018320 DNA_polymerase_1
IPR002298 DNA_polymerase_A
IPR008918 HhH2
IPR029060 PIN-like_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10133 PTHR10133, 1 hit
PfamiView protein in Pfam
PF01367 5_3_exonuc, 1 hit
PF02739 5_3_exonuc_N, 1 hit
PF00476 DNA_pol_A, 1 hit
PRINTSiPR00868 DNAPOLI
SMARTiView protein in SMART
SM00474 35EXOc, 1 hit
SM00475 53EXOc, 1 hit
SM00279 HhH2, 1 hit
SM00482 POLAc, 1 hit
SUPFAMiSSF47807 SSF47807, 1 hit
SSF53098 SSF53098, 1 hit
SSF88723 SSF88723, 1 hit
TIGRFAMsiTIGR00593 pola, 1 hit
PROSITEiView protein in PROSITE
PS00447 DNA_POLYMERASE_A, 1 hit

Sequencei

Sequence statusi: Complete.

P0A551-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTTASAPSE DRAKPTLMLL DGNSLAFRAF YALPAENFKT RGGLTTNAVY
60 70 80 90 100
GFTAMLINLL RDEAPTHIAA AFDVSRQTFR LQRYPEYKAN RSSTPDEFAG
110 120 130 140 150
QIDITKEVLG ALGITVLSEP GFEADDLIAT LATQAENEGY RVLVVTGDRD
160 170 180 190 200
ALQLVSDDVT VLYPRKGVSE LTRFTPEAVV EKYGLTPRQY PDFAALRGDP
210 220 230 240 250
SDNLPGIPGV GEKTAAKWIA EYGSLRSLVD NVDAVRGKVG DALRANLASV
260 270 280 290 300
VRNRELTDLV RDVPLAQTPD TLRLQPWDRD HIHRLFDDLE FRVLRDRLFD
310 320 330 340 350
TLAAAGGPEV DEGFDVRGGA LAPGTVRQWL AEHAGDGRRA GLTVVGTHLP
360 370 380 390 400
HGGDATAMAV AAADGEGAYL DTATLTPDDD AALAAWLADP AKPKALHEAK
410 420 430 440 450
AAVHDLAGRG WTLEGVTSDT ALAAYLVRPG QRSFTLDDLS LRYLRRELRA
460 470 480 490 500
ETPQQQQLSL LDDDDTDAET IQTTILRARA VIDLADALDA ELARIDSTAL
510 520 530 540 550
LGEMELPVQR VLAKMESAGI AVDLPMLTEL QSQFGDQIRD AAEAAYGVIG
560 570 580 590 600
KQINLGSPKQ LQVVLFDELG MPKTKRTKTG YTTDADALQS LFDKTGHPFL
610 620 630 640 650
QHLLAHRDVT RLKVTVDGLL QAVAADGRIH TTFNQTIAAT GRLSSTEPNL
660 670 680 690 700
QNIPIRTDAG RRIRDAFVVG DGYAELMTAD YSQIEMRIMA HLSGDEGLIE
710 720 730 740 750
AFNTGEDLHS FVASRAFGVP IDEVTGELRR RVKAMSYGLA YGLSAYGLSQ
760 770 780 790 800
QLKISTEEAN EQMDAYFARF GGVRDYLRAV VERARKDGYT STVLGRRRYL
810 820 830 840 850
PELDSSNRQV REAAERAALN APIQGSAADI IKVAMIQVDK ALNEAQLASR
860 870 880 890 900
MLLQVHDELL FEIAPGERER VEALVRDKMG GAYPLDVPLE VSVGYGRSWD

AAAH
Length:904
Mass (Da):98,472
Last modified:March 15, 2005 - v1
Checksum:i1C8E560FE5F74323
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIU00259.1
RefSeqiNP_855308.1, NC_002945.3
WP_003408063.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO42904; CDO42904; Mb1655
PATRICifig|233413.5.peg.1806

Similar proteinsi

Entry informationi

Entry nameiDPO1_MYCBO
AccessioniPrimary (citable) accession number: P0A551
Secondary accession number(s): A0A1R3XYV9, Q07700, X2BIE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 25, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health