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Reviewed, UniProtKB/Swiss-Prot P0A543 (DHAS_MYCBO)

Last modified June 16, 2009. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Aspartate-semialdehyde dehydrogenase
      Short name=ASA dehydrogenase
      Short name=ASADH
    EC=1.2.1.11
Gene names
Name: asd
Ordered Locus Names: Mb3735c
OrganismMycobacterium bovis [Complete proteome] [HAMAP]
Taxonomic identifier1765 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; tetrahydrodipicolinate from L-aspartate: step 2/4.

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the aspartate-semialdehyde dehydrogenase family.

Sequence caution

The sequence Z18290 differs from that shown. Reason: Frameshift at position 313.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345Aspartate-semialdehyde dehydrogenase
PRO_0000141381

Sites

Active site1301Acyl-thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A543-1 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: C886DDB63D03E25D

FASTA34536,230
        10         20         30         40         50         60 
MGLSIGIVGA TGQVGQVMRT LLDERDFPAS AVRFFASARS QGRKLAFRGQ EIEVEDAETA 

        70         80         90        100        110        120 
DPSGLDIALF SAGSAMSKVQ APRFAAAGVT VIDNSSAWRK DPDVPLVVSE VNFERDAHRR 

       130        140        150        160        170        180 
PKGIIANPNC TTMAAMPVLK VLHDEARLVR LVVSSYQAVS GSGLAGVAEL AEQARAVIGG 

       190        200        210        220        230        240 
AEQLVYDGGA LEFPPPNTYV APIAFNVVPL AGSLVDDGSG ETDEDQKLRF ESRKILGIPD 

       250        260        270        280        290        300 
LLVSGTCVRV PVFTGHSLSI NAEFAQPLSP ERARELLDGA TGVQLVDVPT PLAAAGVDES 

       310        320        330        340 
LVGRIRRDPG VPDGRGLALF VSGDNLRKGA ALNTIQIAEL LTADL 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and characterization of the aspartokinase and aspartate semialdehyde dehydrogenase operon from mycobacteria."
Cirillo J.D., Weisbrod T.R., Pascopella L., Bloom B.R., Jacobs W.R. Jr.
Mol. Microbiol. 11:629-639(1994) [PubMed: 7910936] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BCG / Pasteur.
[2]"The complete genome sequence of Mycobacterium bovis."
Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. expand/collapse author list , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.
Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases

Z18290 Genomic DNA. No translation available.
BX248347 Genomic DNA. Translation: CAD95921.1.
RefSeqNP_857373.1.

3D structure databases

HSSPHSSP built from PDB template 1BRM based on UniProtKB P00353.
ModBaseSearch...

Genome annotation databases

GeneID1093103.
GenomeReviewsGene locus Mb3735c in contig BX248333_GR.
KEGGmbo:Mb3735c.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP0A543.
OMAP0A543. LELWLCG.

Enzyme and pathway databases

BRENDA1.2.1.11. 3091.

Family and domain databases

InterProIPR000319. Asp-semialdehyde_DH_CS.
IPR012080. Asp_semialdehyde_DH.
IPR005986. Asp_semialdehyde_DH_bac.
IPR000534. Semialdehyde_DH_NAD-bd.
IPR012280. Semialdhyde_DH_C.
[Graphical view]
PfamPF01118. Semialdhyde_dh. 1 hit.
PF02774. Semialdhyde_dhC. 1 hit.
[Graphical view]
PIRSFPIRSF000148. ASA_dh. 1 hit.
TIGRFAMsTIGR01296. asd_B. 1 hit.
PROSITEPS01103. ASD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHAS_MYCBO
AccessionPrimary (citable) accession number: P0A543
Secondary accession number(s): P47730, P97049
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents