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P0A539

- PUNA_MYCBO

UniProt

P0A539 - PUNA_MYCBO

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Protein

Purine nucleoside phosphorylase

Gene
punA, deoD, Mb3335
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine By similarity.

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. purine-nucleoside phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00606.

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylase (EC:2.4.2.1)
Short name:
PNP
Alternative name(s):
Inosine phosphorylase
Inosine-guanosine phosphorylase
Gene namesi
Name:punA
Synonyms:deoD
Ordered Locus Names:Mb3335
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Purine nucleoside phosphorylasePRO_0000184542Add
BLAST

Interactioni

Subunit structurei

Homotrimer By similarity.

Protein-protein interaction databases

STRINGi233413.Mb3335.

Structurei

3D structure databases

ProteinModelPortaliP0A539.
SMRiP0A539. Positions 7-268.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0005.
HOGENOMiHOG000045183.
KOiK03783.
OMAiTHFYEGR.
OrthoDBiEOG6423M2.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
InterProiIPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR011269. PUNP.
IPR011268. Purine_phosphorylase.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PTHR11904:SF9. PTHR11904:SF9. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000477. PurNPase. 1 hit.
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01697. PNPH-PUNA-XAPA. 1 hit.
TIGR01698. PUNP. 1 hit.
PROSITEiPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A539-1 [UniParc]FASTAAdd to Basket

« Hide

MADPRPDPDE LARRAAQVIA DRTGIGEHDV AVVLGSGWLP AVAALGSPTT    50
VLPQAELPGF VPPTAAGHAG ELLSVPIGAH RVLVLAGRIH AYEGHDLRYV 100
VHPVRAARAA GAQIMVLTNA AGGLRADLQV GQPVLISDHL NLTARSPLVG 150
GEFVDLTDAY SPRLRELARQ SDPQLAEGVY AGLPGPHYET PAEIRMLQTL 200
GADLVGMSTV HETIAARAAG AEVLGVSLVT NLAAGITGEP LSHAEVLAAG 250
AASATRMGAL LADVIARF 268
Length:268
Mass (Da):27,572
Last modified:March 15, 2005 - v1
Checksum:i12AA429779CE89F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO44607.1.
RefSeqiNP_856980.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD95427; CAD95427; Mb3335.
GeneIDi1094072.
KEGGimbo:Mb3335.
PATRICi18009074. VBIMycBov88188_3665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO44607.1 .
RefSeqi NP_856980.1. NC_002945.3.

3D structure databases

ProteinModelPortali P0A539.
SMRi P0A539. Positions 7-268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb3335.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD95427 ; CAD95427 ; Mb3335 .
GeneIDi 1094072.
KEGGi mbo:Mb3335.
PATRICi 18009074. VBIMycBov88188_3665.

Phylogenomic databases

eggNOGi COG0005.
HOGENOMi HOG000045183.
KOi K03783.
OMAi THFYEGR.
OrthoDBi EOG6423M2.

Enzyme and pathway databases

UniPathwayi UPA00606 .

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
InterProi IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR011269. PUNP.
IPR011268. Purine_phosphorylase.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
PTHR11904:SF9. PTHR11904:SF9. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF000477. PurNPase. 1 hit.
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01697. PNPH-PUNA-XAPA. 1 hit.
TIGR01698. PUNP. 1 hit.
PROSITEi PS01240. PNP_MTAP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiPUNA_MYCBO
AccessioniPrimary (citable) accession number: P0A539
Secondary accession number(s): O53359, X2BMT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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