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P0A539 (PUNA_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Purine nucleoside phosphorylase

Short name=PNP
EC=2.4.2.1
Alternative name(s):
Inosine phosphorylase
Inosine-guanosine phosphorylase
Gene names
Name:punA
Synonyms:deoD
Ordered Locus Names:Mb3335
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine By similarity.

Catalytic activity

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.

Pathway

Purine metabolism; purine nucleoside salvage.

Subunit structure

Homotrimer By similarity.

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family.

Ontologies

Keywords
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processnucleoside metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionpurine-nucleoside phosphorylase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Purine nucleoside phosphorylase
PRO_0000184542

Sequences

Sequence LengthMass (Da)Tools
P0A539 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 12AA429779CE89F6

FASTA26827,572
        10         20         30         40         50         60 
MADPRPDPDE LARRAAQVIA DRTGIGEHDV AVVLGSGWLP AVAALGSPTT VLPQAELPGF 

        70         80         90        100        110        120 
VPPTAAGHAG ELLSVPIGAH RVLVLAGRIH AYEGHDLRYV VHPVRAARAA GAQIMVLTNA 

       130        140        150        160        170        180 
AGGLRADLQV GQPVLISDHL NLTARSPLVG GEFVDLTDAY SPRLRELARQ SDPQLAEGVY 

       190        200        210        220        230        240 
AGLPGPHYET PAEIRMLQTL GADLVGMSTV HETIAARAAG AEVLGVSLVT NLAAGITGEP 

       250        260 
LSHAEVLAAG AASATRMGAL LADVIARF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248333 Genomic DNA. Translation: CDO44607.1.
RefSeqNP_856980.1. NC_002945.3.

3D structure databases

ProteinModelPortalP0A539.
SMRP0A539. Positions 7-268.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb3335.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD95427; CAD95427; Mb3335.
GeneID1094072.
KEGGmbo:Mb3335.
PATRIC18009074. VBIMycBov88188_3665.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0005.
HOGENOMHOG000045183.
KOK03783.
OMATHFYEGR.
OrthoDBEOG6423M2.

Enzyme and pathway databases

UniPathwayUPA00606.

Family and domain databases

Gene3D3.40.50.1580. 1 hit.
InterProIPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
IPR011269. PUNP.
IPR011268. Purine_phosphorylase.
IPR018099. Purine_phosphorylase-2_CS.
[Graphical view]
PANTHERPTHR11904. PTHR11904. 1 hit.
PTHR11904:SF9. PTHR11904:SF9. 1 hit.
PfamPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
PIRSFPIRSF000477. PurNPase. 1 hit.
SUPFAMSSF53167. SSF53167. 1 hit.
TIGRFAMsTIGR01697. PNPH-PUNA-XAPA. 1 hit.
TIGR01698. PUNP. 1 hit.
PROSITEPS01240. PNP_MTAP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUNA_MYCBO
AccessionPrimary (citable) accession number: P0A539
Secondary accession number(s): O53359, X2BMT9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways