Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0A539

- PUNA_MYCBO

UniProt

P0A539 - PUNA_MYCBO

Protein

Purine nucleoside phosphorylase

Gene

punA

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine By similarity.By similarity

    Catalytic activityi

    Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. purine-nucleoside phosphorylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00606.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Purine nucleoside phosphorylase (EC:2.4.2.1)
    Short name:
    PNP
    Alternative name(s):
    Inosine phosphorylase
    Inosine-guanosine phosphorylase
    Gene namesi
    Name:punA
    Synonyms:deoD
    Ordered Locus Names:Mb3335
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Purine nucleoside phosphorylasePRO_0000184542Add
    BLAST

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    STRINGi233413.Mb3335.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A539.
    SMRiP0A539. Positions 7-268.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PNP/MTAP phosphorylase family.Curated

    Phylogenomic databases

    eggNOGiCOG0005.
    HOGENOMiHOG000045183.
    KOiK03783.
    OMAiTHFYEGR.
    OrthoDBiEOG6423M2.

    Family and domain databases

    Gene3Di3.40.50.1580. 1 hit.
    InterProiIPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR011269. PUNP.
    IPR011268. Purine_phosphorylase.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view]
    PANTHERiPTHR11904. PTHR11904. 1 hit.
    PTHR11904:SF9. PTHR11904:SF9. 1 hit.
    PfamiPF01048. PNP_UDP_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000477. PurNPase. 1 hit.
    SUPFAMiSSF53167. SSF53167. 1 hit.
    TIGRFAMsiTIGR01697. PNPH-PUNA-XAPA. 1 hit.
    TIGR01698. PUNP. 1 hit.
    PROSITEiPS01240. PNP_MTAP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A539-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADPRPDPDE LARRAAQVIA DRTGIGEHDV AVVLGSGWLP AVAALGSPTT    50
    VLPQAELPGF VPPTAAGHAG ELLSVPIGAH RVLVLAGRIH AYEGHDLRYV 100
    VHPVRAARAA GAQIMVLTNA AGGLRADLQV GQPVLISDHL NLTARSPLVG 150
    GEFVDLTDAY SPRLRELARQ SDPQLAEGVY AGLPGPHYET PAEIRMLQTL 200
    GADLVGMSTV HETIAARAAG AEVLGVSLVT NLAAGITGEP LSHAEVLAAG 250
    AASATRMGAL LADVIARF 268
    Length:268
    Mass (Da):27,572
    Last modified:March 15, 2005 - v1
    Checksum:i12AA429779CE89F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO44607.1.
    RefSeqiNP_856980.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD95427; CAD95427; Mb3335.
    GeneIDi1094072.
    KEGGimbo:Mb3335.
    PATRICi18009074. VBIMycBov88188_3665.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO44607.1 .
    RefSeqi NP_856980.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali P0A539.
    SMRi P0A539. Positions 7-268.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb3335.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD95427 ; CAD95427 ; Mb3335 .
    GeneIDi 1094072.
    KEGGi mbo:Mb3335.
    PATRICi 18009074. VBIMycBov88188_3665.

    Phylogenomic databases

    eggNOGi COG0005.
    HOGENOMi HOG000045183.
    KOi K03783.
    OMAi THFYEGR.
    OrthoDBi EOG6423M2.

    Enzyme and pathway databases

    UniPathwayi UPA00606 .

    Family and domain databases

    Gene3Di 3.40.50.1580. 1 hit.
    InterProi IPR000845. Nucleoside_phosphorylase_d.
    IPR001369. PNP/MTAP.
    IPR011269. PUNP.
    IPR011268. Purine_phosphorylase.
    IPR018099. Purine_phosphorylase-2_CS.
    [Graphical view ]
    PANTHERi PTHR11904. PTHR11904. 1 hit.
    PTHR11904:SF9. PTHR11904:SF9. 1 hit.
    Pfami PF01048. PNP_UDP_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000477. PurNPase. 1 hit.
    SUPFAMi SSF53167. SSF53167. 1 hit.
    TIGRFAMsi TIGR01697. PNPH-PUNA-XAPA. 1 hit.
    TIGR01698. PUNP. 1 hit.
    PROSITEi PS01240. PNP_MTAP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiPUNA_MYCBO
    AccessioniPrimary (citable) accession number: P0A539
    Secondary accession number(s): O53359, X2BMT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3