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Protein

Methyl-branched lipid omega-hydroxylase

Gene

cyp124

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate.By similarity

Catalytic activityi

A methyl-branched lipid + O2 + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ = an omega-hydroxy-methyl-branched lipid + H2O + 2 oxidized ferredoxin [iron-sulfur] cluster.By similarity

Cofactori

hemeBy similarity

Pathwayi: branched-chain fatty acid metabolism

This protein is involved in the pathway branched-chain fatty acid metabolism, which is part of Lipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway branched-chain fatty acid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi379 – 3791Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA01022.

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-branched lipid omega-hydroxylaseBy similarity (EC:1.14.15.14By similarity)
Alternative name(s):
Cytochrome P450 124By similarity
Gene namesi
Name:cyp124
Ordered Locus Names:Mb2289
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Methyl-branched lipid omega-hydroxylasePRO_0000052277Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP0A517.
SMRiP0A517. Positions 3-428.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOGENOMiHOG000243680.
OMAiDKVTLWY.
OrthoDBiEOG6QVRCK.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
[Graphical view]
PfamiPF00067. p450. 2 hits.
[Graphical view]
PRINTSiPR00359. BP450.
SUPFAMiSSF48264. SSF48264. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A517-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLNTAIATR VNGTPPPEVP IADIELGSLD FWALDDDVRD GAFATLRREA
60 70 80 90 100
PISFWPTIEL PGFVAGNGHW ALTKYDDVFY ASRHPDIFSS YPNITINDQT
110 120 130 140 150
PELAEYFGSM IVLDDPRHQR LRSIVSRAFT PKVVARIEAA VRDRAHRLVS
160 170 180 190 200
SMIANNPDRQ ADLVSELAGP LPLQIICDMM GIPKADHQRI FHWTNVILGF
210 220 230 240 250
GDPDLATDFD EFMQVSADIG AYATALAEDR RVNHHDDLTS SLVEAEVDGE
260 270 280 290 300
RLSSREIASF FILLVVAGNE TTRNAITHGV LALSRYPEQR DRWWSDFDGL
310 320 330 340 350
APTAVEEIVR WASPVVYMRR TLTQDIELRG TKMAAGDKVS LWYCSANRDE
360 370 380 390 400
SKFADPWTFD LARNPNPHLG FGGGGAHFCL GANLARREIR VAFDELRRQM
410 420
PDVVATEEPA RLLSQFIHGI KTLPVTWS
Length:428
Mass (Da):47,825
Last modified:March 15, 2005 - v1
Checksum:i76B1F3C5AE348591
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43546.1.
RefSeqiNP_855938.1. NC_002945.3.
WP_003411654.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO43546; CDO43546; Mb2289.
GeneIDi1090370.
KEGGimbo:Mb2289.
PATRICi18006738. VBIMycBov88188_2514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43546.1.
RefSeqiNP_855938.1. NC_002945.3.
WP_003411654.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP0A517.
SMRiP0A517. Positions 3-428.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO43546; CDO43546; Mb2289.
GeneIDi1090370.
KEGGimbo:Mb2289.
PATRICi18006738. VBIMycBov88188_2514.

Phylogenomic databases

HOGENOMiHOG000243680.
OMAiDKVTLWY.
OrthoDBiEOG6QVRCK.

Enzyme and pathway databases

UniPathwayiUPA01022.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
[Graphical view]
PfamiPF00067. p450. 2 hits.
[Graphical view]
PRINTSiPR00359. BP450.
SUPFAMiSSF48264. SSF48264. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiCP124_MYCBO
AccessioniPrimary (citable) accession number: P0A517
Secondary accession number(s): Q50696, X2BKK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 8, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.