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P0A509

- BCCA_MYCBO

UniProt

P0A509 - BCCA_MYCBO

Protein

Acetyl-/propionyl-coenzyme A carboxylase alpha chain

Gene

accA1

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    This protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase.By similarity

    Catalytic activityi

    ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].

    Cofactori

    Biotin.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei116 – 1161ATPBy similarity
    Binding sitei200 – 2001ATPBy similarity
    Binding sitei235 – 2351ATPBy similarity
    Active sitei294 – 2941By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. biotin carboxylase activity Source: UniProtKB-EC
    3. metal ion binding Source: InterPro

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Biotin, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyl-/propionyl-coenzyme A carboxylase alpha chain
    Including the following 2 domains:
    Biotin carboxylase (EC:6.3.4.14)
    Biotin carboxyl carrier protein
    Short name:
    BCCP
    Gene namesi
    Name:accA1
    Synonyms:bccA
    Ordered Locus Names:Mb2529c
    OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
    Taxonomic identifieri233413 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000001419: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 654654Acetyl-/propionyl-coenzyme A carboxylase alpha chainPRO_0000146796Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei620 – 6201N6-biotinyllysineBy similarity

    Interactioni

    Subunit structurei

    Multimer comprised of 2 different subunits, the larger one (63/64 kDa) has biotin carboxylase and biotin carrier functions, while the smaller subunit possesses carboxyltransferase and substrate binding activity.By similarity

    Protein-protein interaction databases

    STRINGi233413.Mb2529c.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A509.
    SMRiP0A509. Positions 5-636.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 448448Biotin carboxylationAdd
    BLAST
    Domaini120 – 319200ATP-graspPROSITE-ProRule annotationAdd
    BLAST
    Domaini586 – 65267Biotinyl-bindingAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ATP-grasp domain.PROSITE-ProRule annotation
    Contains 1 biotin carboxylation domain.Curated
    Contains 1 biotinyl-binding domain.Curated

    Phylogenomic databases

    eggNOGiCOG4770.
    HOGENOMiHOG000008989.
    KOiK11263.
    OMAiNTAYLRR.
    OrthoDBiEOG6CVV6Z.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR001882. Biotin_BS.
    IPR011764. Biotin_carboxylation_dom.
    IPR005482. Biotin_COase_C.
    IPR000089. Biotin_lipoyl.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF02785. Biotin_carb_C. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF00289. CPSase_L_chain. 1 hit.
    PF02786. CPSase_L_D2. 1 hit.
    [Graphical view]
    SMARTiSM00878. Biotin_carb_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF51230. SSF51230. 1 hit.
    SSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    PS00188. BIOTIN. 1 hit.
    PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00866. CPSASE_1. 1 hit.
    PS00867. CPSASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A509-1 [UniParc]FASTAAdd to Basket

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    MFDTVLVANR GEIAVRVIRT LRRLGIRSVA VYSDPDVDAR HVLEADAAVR    50
    LGPAPARESY LDIGKVLDAA ARTGAQAIHP GYGFLAENAD FAAACERARV 100
    VFLGPPARAI EVMGDKIAAK NAVAAFDVPV VPGVARAGLT DDALVTAAAE 150
    VGYPVLIKPS AGGGGKGMRL VQDPARLPEA LVSARREAMS SFGDDTLFLE 200
    RFVLRPRHIE VQVLADAHGN VVHLGERECS LQRRHQKVIE EAPSPLLDPQ 250
    TRERIGVAAC NTARCVDYVG AGTVEFIVSA QRPDEFFFME MNTRLQVEHP 300
    VTEAITGLDL VEWQLRVGAG EKLGFAQNDI ELRGHAIEAR VYAEDPAREF 350
    LPTGGRVLAV FEPAGPGVRV DSSLLGGTVV GSDYDPLLTK VIAHGADREE 400
    ALDRLDQALA RTAVLGVQTN VEFLRFLLAD ERVRVGDLDT AVLDERSADF 450
    TARPAPDDVL AAGGLYRQWA LARRAQGDLW AAPSGWRGGG HMAPVRTAMR 500
    TPLRSETVSV WGPPESAQVQ VGDGEIDCAS VQVTREQMSV TISGLRRDYR 550
    WAEADRHLWI ADERGTWHLR EAEEHKIHRA VGARPAEVVS PMPGSVIAVQ 600
    VESGSQISAG DVVVVVEAMK MEHSLEAPVS GRVQVLVSVG DQVKVEQVLA 650
    RIKD 654
    Length:654
    Mass (Da):70,592
    Last modified:March 15, 2005 - v1
    Checksum:iFAA0A1A46432CABF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43791.1.
    RefSeqiNP_856174.1. NC_002945.3.

    Genome annotation databases

    EnsemblBacteriaiCAD97390; CAD97390; Mb2529c.
    GeneIDi1090579.
    KEGGimbo:Mb2529c.
    PATRICi18007289. VBIMycBov88188_2784.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248333 Genomic DNA. Translation: CDO43791.1 .
    RefSeqi NP_856174.1. NC_002945.3.

    3D structure databases

    ProteinModelPortali P0A509.
    SMRi P0A509. Positions 5-636.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 233413.Mb2529c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD97390 ; CAD97390 ; Mb2529c .
    GeneIDi 1090579.
    KEGGi mbo:Mb2529c.
    PATRICi 18007289. VBIMycBov88188_2784.

    Phylogenomic databases

    eggNOGi COG4770.
    HOGENOMi HOG000008989.
    KOi K11263.
    OMAi NTAYLRR.
    OrthoDBi EOG6CVV6Z.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR001882. Biotin_BS.
    IPR011764. Biotin_carboxylation_dom.
    IPR005482. Biotin_COase_C.
    IPR000089. Biotin_lipoyl.
    IPR005481. CarbamoylP_synth_lsu_N.
    IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
    IPR016185. PreATP-grasp_dom.
    IPR011054. Rudment_hybrid_motif.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF02785. Biotin_carb_C. 1 hit.
    PF00364. Biotin_lipoyl. 1 hit.
    PF00289. CPSase_L_chain. 1 hit.
    PF02786. CPSase_L_D2. 1 hit.
    [Graphical view ]
    SMARTi SM00878. Biotin_carb_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51230. SSF51230. 1 hit.
    SSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS50979. BC. 1 hit.
    PS00188. BIOTIN. 1 hit.
    PS50968. BIOTINYL_LIPOYL. 1 hit.
    PS00866. CPSASE_1. 1 hit.
    PS00867. CPSASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-935 / AF2122/97.

    Entry informationi

    Entry nameiBCCA_MYCBO
    AccessioniPrimary (citable) accession number: P0A509
    Secondary accession number(s): P46401, X2BLJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3