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Protein

Acetyl-/propionyl-coenzyme A carboxylase alpha chain

Gene

accA1

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase.By similarity

Catalytic activityi

ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate- = ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine.

Cofactori

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116ATPBy similarity1
Binding sitei200ATPBy similarity1
Binding sitei235ATPBy similarity1
Active sitei294By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Multifunctional enzyme
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Biotin, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-2607-MONOMER
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-/propionyl-coenzyme A carboxylase alpha chain
Including the following 2 domains:
Biotin carboxylase (EC:6.3.4.14)
Biotin carboxyl carrier protein
Short name:
BCCP
Gene namesi
Name:accA1
Synonyms:bccA
Ordered Locus Names:BQ2027_MB2529C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001467961 – 654Acetyl-/propionyl-coenzyme A carboxylase alpha chainAdd BLAST654

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei620N6-biotinyllysinePROSITE-ProRule annotationBy similarity1

Interactioni

Subunit structurei

Multimer comprised of 2 different subunits, the larger one (63/64 kDa) has biotin carboxylase and biotin carrier functions, while the smaller subunit possesses carboxyltransferase and substrate binding activity.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0A509
SMRiP0A509
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 448Biotin carboxylationAdd BLAST448
Domaini120 – 319ATP-graspPROSITE-ProRule annotationAdd BLAST200
Domaini578 – 653Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST76

Phylogenomic databases

HOGENOMiHOG000008989
OMAiDYDPMLA

Family and domain databases

InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR005481 BC-like_N
IPR001882 Biotin_BS
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR000089 Biotin_lipoyl
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR011054 Rudment_hybrid_motif
IPR011053 Single_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF00364 Biotin_lipoyl, 1 hit
PF02786 CPSase_L_D2, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51230 SSF51230, 1 hit
SSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00188 BIOTIN, 1 hit
PS50968 BIOTINYL_LIPOYL, 1 hit
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0A509-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDTVLVANR GEIAVRVIRT LRRLGIRSVA VYSDPDVDAR HVLEADAAVR
60 70 80 90 100
LGPAPARESY LDIGKVLDAA ARTGAQAIHP GYGFLAENAD FAAACERARV
110 120 130 140 150
VFLGPPARAI EVMGDKIAAK NAVAAFDVPV VPGVARAGLT DDALVTAAAE
160 170 180 190 200
VGYPVLIKPS AGGGGKGMRL VQDPARLPEA LVSARREAMS SFGDDTLFLE
210 220 230 240 250
RFVLRPRHIE VQVLADAHGN VVHLGERECS LQRRHQKVIE EAPSPLLDPQ
260 270 280 290 300
TRERIGVAAC NTARCVDYVG AGTVEFIVSA QRPDEFFFME MNTRLQVEHP
310 320 330 340 350
VTEAITGLDL VEWQLRVGAG EKLGFAQNDI ELRGHAIEAR VYAEDPAREF
360 370 380 390 400
LPTGGRVLAV FEPAGPGVRV DSSLLGGTVV GSDYDPLLTK VIAHGADREE
410 420 430 440 450
ALDRLDQALA RTAVLGVQTN VEFLRFLLAD ERVRVGDLDT AVLDERSADF
460 470 480 490 500
TARPAPDDVL AAGGLYRQWA LARRAQGDLW AAPSGWRGGG HMAPVRTAMR
510 520 530 540 550
TPLRSETVSV WGPPESAQVQ VGDGEIDCAS VQVTREQMSV TISGLRRDYR
560 570 580 590 600
WAEADRHLWI ADERGTWHLR EAEEHKIHRA VGARPAEVVS PMPGSVIAVQ
610 620 630 640 650
VESGSQISAG DVVVVVEAMK MEHSLEAPVS GRVQVLVSVG DQVKVEQVLA

RIKD
Length:654
Mass (Da):70,592
Last modified:March 15, 2005 - v1
Checksum:iFAA0A1A46432CABF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIU01145.1
RefSeqiNP_856174.1, NC_002945.3
WP_003899356.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO43791; CDO43791; Mb2529c
PATRICifig|233413.5.peg.2784

Similar proteinsi

Entry informationi

Entry nameiBCCA_MYCBO
AccessioniPrimary (citable) accession number: P0A509
Secondary accession number(s): A0A1R3Y3I1, P46401, X2BLJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 25, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health