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P0A509

- BCCA_MYCBO

UniProt

P0A509 - BCCA_MYCBO

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Protein
Acetyl-/propionyl-coenzyme A carboxylase alpha chain
Gene
accA1, bccA, Mb2529c
Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase By similarity.

Catalytic activityi

ATP + biotin-[carboxyl-carrier-protein] + CO2 = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].

Cofactori

Biotin.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei116 – 1161ATP By similarity
Binding sitei200 – 2001ATP By similarity
Binding sitei235 – 2351ATP By similarity
Active sitei294 – 2941 By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. biotin carboxylase activity Source: UniProtKB-EC
  3. metal ion binding Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

ATP-binding, Biotin, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-/propionyl-coenzyme A carboxylase alpha chain
Including the following 2 domains:
Biotin carboxylase (EC:6.3.4.14)
Biotin carboxyl carrier protein
Short name:
BCCP
Gene namesi
Name:accA1
Synonyms:bccA
Ordered Locus Names:Mb2529c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000001419: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 654654Acetyl-/propionyl-coenzyme A carboxylase alpha chain
PRO_0000146796Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei620 – 6201N6-biotinyllysine By similarity

Interactioni

Subunit structurei

Multimer comprised of 2 different subunits, the larger one (63/64 kDa) has biotin carboxylase and biotin carrier functions, while the smaller subunit possesses carboxyltransferase and substrate binding activity By similarity.

Protein-protein interaction databases

STRINGi233413.Mb2529c.

Structurei

3D structure databases

ProteinModelPortaliP0A509.
SMRiP0A509. Positions 5-636.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 448448Biotin carboxylation
Add
BLAST
Domaini120 – 319200ATP-grasp
Add
BLAST
Domaini586 – 65267Biotinyl-binding
Add
BLAST

Sequence similaritiesi

Contains 1 ATP-grasp domain.

Phylogenomic databases

eggNOGiCOG4770.
HOGENOMiHOG000008989.
KOiK11263.
OMAiNTAYLRR.
OrthoDBiEOG6CVV6Z.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A509-1 [UniParc]FASTAAdd to Basket

« Hide

MFDTVLVANR GEIAVRVIRT LRRLGIRSVA VYSDPDVDAR HVLEADAAVR    50
LGPAPARESY LDIGKVLDAA ARTGAQAIHP GYGFLAENAD FAAACERARV 100
VFLGPPARAI EVMGDKIAAK NAVAAFDVPV VPGVARAGLT DDALVTAAAE 150
VGYPVLIKPS AGGGGKGMRL VQDPARLPEA LVSARREAMS SFGDDTLFLE 200
RFVLRPRHIE VQVLADAHGN VVHLGERECS LQRRHQKVIE EAPSPLLDPQ 250
TRERIGVAAC NTARCVDYVG AGTVEFIVSA QRPDEFFFME MNTRLQVEHP 300
VTEAITGLDL VEWQLRVGAG EKLGFAQNDI ELRGHAIEAR VYAEDPAREF 350
LPTGGRVLAV FEPAGPGVRV DSSLLGGTVV GSDYDPLLTK VIAHGADREE 400
ALDRLDQALA RTAVLGVQTN VEFLRFLLAD ERVRVGDLDT AVLDERSADF 450
TARPAPDDVL AAGGLYRQWA LARRAQGDLW AAPSGWRGGG HMAPVRTAMR 500
TPLRSETVSV WGPPESAQVQ VGDGEIDCAS VQVTREQMSV TISGLRRDYR 550
WAEADRHLWI ADERGTWHLR EAEEHKIHRA VGARPAEVVS PMPGSVIAVQ 600
VESGSQISAG DVVVVVEAMK MEHSLEAPVS GRVQVLVSVG DQVKVEQVLA 650
RIKD 654
Length:654
Mass (Da):70,592
Last modified:March 15, 2005 - v1
Checksum:iFAA0A1A46432CABF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43791.1.
RefSeqiNP_856174.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCAD97390; CAD97390; Mb2529c.
GeneIDi1090579.
KEGGimbo:Mb2529c.
PATRICi18007289. VBIMycBov88188_2784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248333 Genomic DNA. Translation: CDO43791.1 .
RefSeqi NP_856174.1. NC_002945.3.

3D structure databases

ProteinModelPortali P0A509.
SMRi P0A509. Positions 5-636.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 233413.Mb2529c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD97390 ; CAD97390 ; Mb2529c .
GeneIDi 1090579.
KEGGi mbo:Mb2529c.
PATRICi 18007289. VBIMycBov88188_2784.

Phylogenomic databases

eggNOGi COG4770.
HOGENOMi HOG000008989.
KOi K11263.
OMAi NTAYLRR.
OrthoDBi EOG6CVV6Z.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view ]
Pfami PF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view ]
SMARTi SM00878. Biotin_carb_C. 1 hit.
[Graphical view ]
SUPFAMi SSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-935 / AF2122/97.

Entry informationi

Entry nameiBCCA_MYCBO
AccessioniPrimary (citable) accession number: P0A509
Secondary accession number(s): P46401, X2BLJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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