Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Acetyl-/propionyl-coenzyme A carboxylase alpha chain

Gene

accA1

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase.By similarity

Catalytic activityi

ATP + biotin-[carboxyl-carrier-protein] + HCO3- = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein].

Cofactori

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei116ATPBy similarity1
Binding sitei200ATPBy similarity1
Binding sitei235ATPBy similarity1
Active sitei294By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

ATP-binding, Biotin, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-/propionyl-coenzyme A carboxylase alpha chain
Including the following 2 domains:
Biotin carboxylase (EC:6.3.4.14)
Biotin carboxyl carrier protein
Short name:
BCCP
Gene namesi
Name:accA1
Synonyms:bccA
Ordered Locus Names:Mb2529c
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001467961 – 654Acetyl-/propionyl-coenzyme A carboxylase alpha chainAdd BLAST654

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei620N6-biotinyllysinePROSITE-ProRule annotationBy similarity1

Interactioni

Subunit structurei

Multimer comprised of 2 different subunits, the larger one (63/64 kDa) has biotin carboxylase and biotin carrier functions, while the smaller subunit possesses carboxyltransferase and substrate binding activity.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0A509.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 448Biotin carboxylationAdd BLAST448
Domaini120 – 319ATP-graspPROSITE-ProRule annotationAdd BLAST200
Domaini578 – 653Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Contains 1 ATP-grasp domain.PROSITE-ProRule annotation
Contains 1 biotin carboxylation domain.Curated
Contains 1 biotinyl-binding domain.PROSITE-ProRule annotationCurated

Phylogenomic databases

HOGENOMiHOG000008989.
KOiK11263.
OMAiGEMHAIE.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005481. BC-like_N.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF02785. Biotin_carb_C. 1 hit.
PF00289. Biotin_carb_N. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A509-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDTVLVANR GEIAVRVIRT LRRLGIRSVA VYSDPDVDAR HVLEADAAVR
60 70 80 90 100
LGPAPARESY LDIGKVLDAA ARTGAQAIHP GYGFLAENAD FAAACERARV
110 120 130 140 150
VFLGPPARAI EVMGDKIAAK NAVAAFDVPV VPGVARAGLT DDALVTAAAE
160 170 180 190 200
VGYPVLIKPS AGGGGKGMRL VQDPARLPEA LVSARREAMS SFGDDTLFLE
210 220 230 240 250
RFVLRPRHIE VQVLADAHGN VVHLGERECS LQRRHQKVIE EAPSPLLDPQ
260 270 280 290 300
TRERIGVAAC NTARCVDYVG AGTVEFIVSA QRPDEFFFME MNTRLQVEHP
310 320 330 340 350
VTEAITGLDL VEWQLRVGAG EKLGFAQNDI ELRGHAIEAR VYAEDPAREF
360 370 380 390 400
LPTGGRVLAV FEPAGPGVRV DSSLLGGTVV GSDYDPLLTK VIAHGADREE
410 420 430 440 450
ALDRLDQALA RTAVLGVQTN VEFLRFLLAD ERVRVGDLDT AVLDERSADF
460 470 480 490 500
TARPAPDDVL AAGGLYRQWA LARRAQGDLW AAPSGWRGGG HMAPVRTAMR
510 520 530 540 550
TPLRSETVSV WGPPESAQVQ VGDGEIDCAS VQVTREQMSV TISGLRRDYR
560 570 580 590 600
WAEADRHLWI ADERGTWHLR EAEEHKIHRA VGARPAEVVS PMPGSVIAVQ
610 620 630 640 650
VESGSQISAG DVVVVVEAMK MEHSLEAPVS GRVQVLVSVG DQVKVEQVLA

RIKD
Length:654
Mass (Da):70,592
Last modified:March 15, 2005 - v1
Checksum:iFAA0A1A46432CABF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43791.1.
RefSeqiNP_856174.1. NC_002945.3.
WP_003899356.1. NC_002945.3.

Genome annotation databases

EnsemblBacteriaiCDO43791; CDO43791; Mb2529c.
GeneIDi1090579.
KEGGimbo:Mb2529c.
PATRICi18007289. VBIMycBov88188_2784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248333 Genomic DNA. Translation: CDO43791.1.
RefSeqiNP_856174.1. NC_002945.3.
WP_003899356.1. NC_002945.3.

3D structure databases

ProteinModelPortaliP0A509.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCDO43791; CDO43791; Mb2529c.
GeneIDi1090579.
KEGGimbo:Mb2529c.
PATRICi18007289. VBIMycBov88188_2784.

Phylogenomic databases

HOGENOMiHOG000008989.
KOiK11263.
OMAiGEMHAIE.

Enzyme and pathway databases

UniPathwayiUPA00094.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005481. BC-like_N.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF02785. Biotin_carb_C. 1 hit.
PF00289. Biotin_carb_N. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
[Graphical view]
SMARTiSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMiSSF51230. SSF51230. 1 hit.
SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00866. CPSASE_1. 1 hit.
PS00867. CPSASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCCA_MYCBO
AccessioniPrimary (citable) accession number: P0A509
Secondary accession number(s): P46401, X2BLJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.