ID   ADHC_MYCBO              Reviewed;         346 AA.
AC   P0A4X1; P31975;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   16-JUN-2009, entry version 26.
DE   RecName: Full=NADP-dependent alcohol dehydrogenase C;
DE            EC=1.1.1.2;
GN   Name=adhC; Synonyms=adh; OrderedLocusNames=Mb3071;
OS   Mycobacterium bovis.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1765;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BCG;
RX   MEDLINE=93051365; PubMed=1427101; DOI=10.1016/0378-1119(92)90164-K;
RA   Stelandre M., Bosseloir Y., de Bruyn J., Maes P., Content J.;
RT   "Cloning and sequence analysis of the gene encoding an NADP-dependent
RT   alcohol dehydrogenase in Mycobacterium bovis BCG.";
RL   Gene 121:79-86(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   MEDLINE=22709107; PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H.,
RA   Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S.,
RA   Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R.,
RA   Parkhill J., Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
CC   -!- CATALYTIC ACTIVITY: An alcohol + NADP(+) = an aldehyde + NADPH.
CC   -!- COFACTOR: Binds 2 zinc ions per subunit (By similarity).
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family.
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DR   EMBL; X63450; CAA45049.1; -; Genomic_DNA.
DR   EMBL; BX248344; CAD96758.1; -; Genomic_DNA.
DR   PIR; JC1376; JC1376.
DR   RefSeq; NP_856716.1; -.
DR   GeneID; 1092114; -.
DR   GenomeReviews; BX248333_GR; Mb3071.
DR   KEGG; mbo:Mb3071; -.
DR   HOGENOM; P0A4X1; -.
DR   OMA; P0A4X1; ERTTIER.
DR   BRENDA; 1.1.1.2; 3091.
DR   GO; GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IEA:EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013154; ADH_GroES-like.
DR   InterPro; IPR002085; ADH_SF_Zn.
DR   InterPro; IPR013149; ADH_Zn-bd.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   PANTHER; PTHR11695; ADH_Sf_Zn; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Metal-binding; NADP; Oxidoreductase; Zinc.
FT   CHAIN         1    346       NADP-dependent alcohol dehydrogenase C.
FT                                /FTId=PRO_0000160744.
FT   METAL        41     41       Zinc 1; catalytic (By similarity).
FT   METAL        63     63       Zinc 1; catalytic (By similarity).
FT   METAL        94     94       Zinc 2 (By similarity).
FT   METAL        97     97       Zinc 2 (By similarity).
FT   METAL       100    100       Zinc 2 (By similarity).
FT   METAL       108    108       Zinc 2 (By similarity).
FT   METAL       158    158       Zinc 1; catalytic (By similarity).
SQ   SEQUENCE   346 AA;  37075 MW;  969179113DBA27C1 CRC64;
     MSTVAAYAAM SATEPLTKTT ITRRDPGPHD VAIDIKFAGI CHSDIHTVKA EWGQPNYPVV
     PGHEIAGVVT AVGSEVTKYR QGDRVGVGCF VDSCRECNSC TRGIEQYCKP GANFTYNSIG
     KDGQPTQGGY SEAIVVDENY VLRIPDVLPL DVAAPLLCAG ITLYSPLRHW NAGANTRVAI
     IGLGGLGHMG VKLGAAMGAD VTVLSQSLKK MEDGLRLGAK SYYATADPDT FRKLRGGFDL
     ILNTVSANLD LGQYLNLLDV DGTLVELGIP EHPMAVPAFA LALMRRSLAG SNIGGIAETQ
     EMLNFCAEHG VTPEIELIEP DYINDAYERV LASDVRYRFV IDISAL
//