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Reviewed, UniProtKB/Swiss-Prot P0A4X1 (ADHC_MYCBO)

Last modified June 16, 2009. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    NADP-dependent alcohol dehydrogenase C
    EC=1.1.1.2
Gene names
Name: adhC
Synonyms: adh
Ordered Locus Names: Mb3071
OrganismMycobacterium bovis [Complete proteome] [HAMAP]
Taxonomic identifier1765 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

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Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

An alcohol + NADP+ = an aldehyde + NADPH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

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Ontologies

Keywords
   LigandMetal-binding
NADP
Zinc
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionalcohol dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: EC

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346NADP-dependent alcohol dehydrogenase C
PRO_0000160744

Sites

Metal binding411Zinc 1; catalytic By similarity
Metal binding631Zinc 1; catalytic By similarity
Metal binding941Zinc 2 By similarity
Metal binding971Zinc 2 By similarity
Metal binding1001Zinc 2 By similarity
Metal binding1081Zinc 2 By similarity
Metal binding1581Zinc 1; catalytic By similarity

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Sequences

Sequence LengthMass (Da)Tools
P0A4X1-1 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 969179113DBA27C1

FASTA34637,075
        10         20         30         40         50         60 
MSTVAAYAAM SATEPLTKTT ITRRDPGPHD VAIDIKFAGI CHSDIHTVKA EWGQPNYPVV 

        70         80         90        100        110        120 
PGHEIAGVVT AVGSEVTKYR QGDRVGVGCF VDSCRECNSC TRGIEQYCKP GANFTYNSIG 

       130        140        150        160        170        180 
KDGQPTQGGY SEAIVVDENY VLRIPDVLPL DVAAPLLCAG ITLYSPLRHW NAGANTRVAI 

       190        200        210        220        230        240 
IGLGGLGHMG VKLGAAMGAD VTVLSQSLKK MEDGLRLGAK SYYATADPDT FRKLRGGFDL 

       250        260        270        280        290        300 
ILNTVSANLD LGQYLNLLDV DGTLVELGIP EHPMAVPAFA LALMRRSLAG SNIGGIAETQ 

       310        320        330        340 
EMLNFCAEHG VTPEIELIEP DYINDAYERV LASDVRYRFV IDISAL

« Hide

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References

« Hide 'large scale' references
[1]"Cloning and sequence analysis of the gene encoding an NADP-dependent alcohol dehydrogenase in Mycobacterium bovis BCG."
Stelandre M., Bosseloir Y., de Bruyn J., Maes P., Content J.
Gene 121:79-86(1992) [PubMed: 1427101] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BCG.
[2]"The complete genome sequence of Mycobacterium bovis."
Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. expand/collapse author list , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.
Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-935 / AF2122/97.

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Cross-references

Sequence databases

X63450 Genomic DNA. Translation: CAA45049.1.
BX248344 Genomic DNA. Translation: CAD96758.1.
PIRJC1376.
RefSeqNP_856716.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID1092114.
GenomeReviewsGene locus Mb3071 in contig BX248333_GR.
KEGGmbo:Mb3071.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP0A4X1.
OMAP0A4X1. ERTTIER.

Enzyme and pathway databases

BRENDA1.1.1.2. 3091.

Family and domain databases

InterProIPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn.
IPR013149. ADH_Zn-bd.
IPR002328. ADH_Zn_CS.
[Graphical view]
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameADHC_MYCBO
AccessionPrimary (citable) accession number: P0A4X1
Secondary accession number(s): P31975
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents