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Protein

NADP-dependent alcohol dehydrogenase C

Gene

adhC

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An alcohol + NADP+ = an aldehyde + NADPH.

Cofactori

Zn2+HMP:Note: Binds 2 Zn2+ ions per subunit.HMP:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi41Zinc 1; catalyticHMP:1
Metal bindingi63Zinc 1; catalyticHMP:1
Metal bindingi94Zinc 2HMP:1
Metal bindingi97Zinc 2HMP:1
Metal bindingi100Zinc 2HMP:1
Metal bindingi108Zinc 2HMP:1
Metal bindingi158Zinc 1; catalyticHMP:1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NADP, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-dependent alcohol dehydrogenase C (EC:1.1.1.2)
Gene namesi
Name:adhC
Synonyms:adh
Ordered Locus Names:BQ2027_MB3071
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607441 – 346NADP-dependent alcohol dehydrogenase CAdd BLAST346

Structurei

3D structure databases

ProteinModelPortaliP0A4X1.
SMRiP0A4X1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000294667.
KOiK13979.
OMAiYRFSIDM.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like_sf.
IPR036291. NAD(P)-bd_dom_sf.
IPR020843. PKS_ER.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SMARTiView protein in SMART
SM00829. PKS_ER. 1 hit.
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A4X1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTVAAYAAM SATEPLTKTT ITRRDPGPHD VAIDIKFAGI CHSDIHTVKA
60 70 80 90 100
EWGQPNYPVV PGHEIAGVVT AVGSEVTKYR QGDRVGVGCF VDSCRECNSC
110 120 130 140 150
TRGIEQYCKP GANFTYNSIG KDGQPTQGGY SEAIVVDENY VLRIPDVLPL
160 170 180 190 200
DVAAPLLCAG ITLYSPLRHW NAGANTRVAI IGLGGLGHMG VKLGAAMGAD
210 220 230 240 250
VTVLSQSLKK MEDGLRLGAK SYYATADPDT FRKLRGGFDL ILNTVSANLD
260 270 280 290 300
LGQYLNLLDV DGTLVELGIP EHPMAVPAFA LALMRRSLAG SNIGGIAETQ
310 320 330 340
EMLNFCAEHG VTPEIELIEP DYINDAYERV LASDVRYRFV IDISAL
Length:346
Mass (Da):37,075
Last modified:March 15, 2005 - v1
Checksum:i969179113DBA27C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63450 Genomic DNA. Translation: CAA45049.1.
LT708304 Genomic DNA. Translation: SIU01696.1.
PIRiJC1376.
RefSeqiNP_856716.1. NC_002945.3.
WP_003415965.1. NC_002945.4.

Genome annotation databases

EnsemblBacteriaiCDO44340; CDO44340; Mb3071.
KEGGimbo:Mb3071.
PATRICifig|233413.5.peg.3374.

Similar proteinsi

Entry informationi

Entry nameiADHC_MYCBO
AccessioniPrimary (citable) accession number: P0A4X1
Secondary accession number(s): A0A1R3Y3Q1, P31975, X2BMX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 22, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families