P0A4X0 (ADHC_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADP-dependent alcohol dehydrogenase C
EC=1.1.1.2

Gene names

Name:	adhC
Synonyms:	adh
Ordered Locus Names:	Rv3045, MT3130
ORF Names:	MTV012.60

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	An alcohol + NADP+ = an aldehyde + NADPH.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Ligand	Metal-binding NADP Zinc
Molecular function	Oxidoreductase
PTM	Isopeptide bond Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cell wall Inferred from direct assay. Source: MTBBASE cytosol Inferred from direct assay. Source: MTBBASE plasma membrane Inferred from direct assay. Source: MTBBASE
Molecular function	alcohol dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	NADP-dependent alcohol dehydrogenase C		PRO_0000160745
Sites
	Metal binding	41	1	Zinc 1; catalytic By similarity
	Metal binding	63	1	Zinc 1; catalytic By similarity
	Metal binding	94	1	Zinc 2 By similarity
	Metal binding	97	1	Zinc 2 By similarity
	Metal binding	100	1	Zinc 2 By similarity
	Metal binding	108	1	Zinc 2 By similarity
	Metal binding	158	1	Zinc 1; catalytic By similarity
Amino acid modifications
	Cross-link	209		Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)

Sequences

	Sequence		Length	Mass (Da)
	P0A4X0 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 969179113DBA27C1	FASTA	346	37,075
	10 20 30 40 50 60 MSTVAAYAAM SATEPLTKTT ITRRDPGPHD VAIDIKFAGI CHSDIHTVKA EWGQPNYPVV 70 80 90 100 110 120 PGHEIAGVVT AVGSEVTKYR QGDRVGVGCF VDSCRECNSC TRGIEQYCKP GANFTYNSIG 130 140 150 160 170 180 KDGQPTQGGY SEAIVVDENY VLRIPDVLPL DVAAPLLCAG ITLYSPLRHW NAGANTRVAI 190 200 210 220 230 240 IGLGGLGHMG VKLGAAMGAD VTVLSQSLKK MEDGLRLGAK SYYATADPDT FRKLRGGFDL 250 260 270 280 290 300 ILNTVSANLD LGQYLNLLDV DGTLVELGIP EHPMAVPAFA LALMRRSLAG SNIGGIAETQ 310 320 330 340 EMLNFCAEHG VTPEIELIEP DYINDAYERV LASDVRYRFV IDISAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
[3]	"Prokayrotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis." Festa R.A., McAllister F., Pearce M.J., Mintseris J., Burns K.E., Gygi S.P., Darwin K.H. PLoS ONE 5:E8589-E8589(2010) [PubMed: 20066036] [Abstract] Cited for: PUPYLATION AT LYS-209, IDENTIFICATION BY MASS SPECTROMETRY. Strain: ATCC 25618 / H37Rv.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842581 Genomic DNA. Translation: CAA16130.1. AE000516 Genomic DNA. Translation: AAK47460.1.
PIR	H70860.
RefSeq	NP_217561.1. NC_000962.2. NP_337646.1. NC_002755.2.
3D structure databases
ProteinModelPortal	P0A4X0.
SMR	P0A4X0. Positions 9-346.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000002424; EBMYCP00000002424; EBMYCG00000002422. EBMYCT00000070787; EBMYCP00000068846; EBMYCG00000070782.
GeneID	888888. 923169.
GenomeReviews	Gene locus MT3130 in contig AE000516_GR. Gene locus Rv3045 in contig AL123456_GR.
KEGG	mtc:MT3130. mtu:Rv3045.
PATRIC	18128644. VBIMycTub22151_3420.
TIGR	MT3130.
Organism-specific databases
TubercuList	Rv3045.
Phylogenomic databases
GeneTree	EBGT00050000015148.
HOGENOM	HBG753318.
OMA	WNAYLNL.
PhylomeDB	P0A4X0.
ProtClustDB	CLSK792243.
Family and domain databases
InterPro	IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR002328. ADH_Zn_CS. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K13979.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 1 hit.
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADHC_MYCTU

Accession

Primary (citable) accession number: P0A4X0
Secondary accession number(s): P31975

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program