P0A4X0 (ADHC_MYCTU) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 43.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: NADP-dependent alcohol dehydrogenase C EC=1.1.1.2 | ||||||||
| Gene names |
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| Organism | Mycobacterium tuberculosis | ||||||||
| Taxonomic identifier | 1773 [NCBI] | ||||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 346 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | An alcohol + NADP+ = an aldehyde + NADPH. |
| Cofactor | Binds 2 zinc ions per subunit By similarity. |
| Sequence similarities | Belongs to the zinc-containing alcohol dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | Metal-binding NADP Zinc |
| Molecular function | Oxidoreductase |
| PTM | Isopeptide bond Ubl conjugation |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | cell wall Inferred from direct assay. Source: MTBBASE cytosolInferred from direct assay. Source: MTBBASE plasma membraneInferred from direct assay. Source: MTBBASE |
| Molecular function | alcohol dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC nucleotide bindingInferred from electronic annotation. Source: InterPro zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 346 | 346 | NADP-dependent alcohol dehydrogenase C | PRO_0000160745 | |||||
Sites | |||||||||
| Metal binding | 41 | 1 | Zinc 1; catalytic By similarity | ||||||
| Metal binding | 63 | 1 | Zinc 1; catalytic By similarity | ||||||
| Metal binding | 94 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 97 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 100 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 108 | 1 | Zinc 2 By similarity | ||||||
| Metal binding | 158 | 1 | Zinc 1; catalytic By similarity | ||||||
Amino acid modifications | |||||||||
| Cross-link | 209 | Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup) | |||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX842581 Genomic DNA. Translation: CAA16130.1. AE000516 Genomic DNA. Translation: AAK47460.1. |
| PIR | H70860. |
| RefSeq | NP_217561.1. NC_000962.2. NP_337646.1. NC_002755.2. |
3D structure databases | |
| ProteinModelPortal | P0A4X0. |
| SMR | P0A4X0. Positions 9-346. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBMYCT00000002424; EBMYCP00000002424; EBMYCG00000002422. EBMYCT00000070787; EBMYCP00000068846; EBMYCG00000070782. |
| GeneID | 888888. 923169. |
| GenomeReviews | Gene locus MT3130 in contig AE000516_GR. Gene locus Rv3045 in contig AL123456_GR. |
| KEGG | mtc:MT3130. mtu:Rv3045. |
| PATRIC | 18128644. VBIMycTub22151_3420. |
| TIGR | MT3130. |
Organism-specific databases | |
| TubercuList | Rv3045. |
Phylogenomic databases | |
| GeneTree | EBGT00050000015148. |
| HOGENOM | HBG753318. |
| OMA | WNAYLNL. |
| PhylomeDB | P0A4X0. |
| ProtClustDB | CLSK792243. |
Family and domain databases | |
| InterPro | IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR002328. ADH_Zn_CS. IPR011032. GroES-like. IPR016040. NAD(P)-bd_dom. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| KO | K13979. |
| PANTHER | PTHR11695. ADH_Sf_Zn. 1 hit. |
| Pfam | PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view] |
| SUPFAM | SSF50129. GroES_like. 1 hit. |
| PROSITE | PS00059. ADH_ZINC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ADHC_MYCTU | ||||||||
| Accession | Primary (citable) accession number: P0A4X0 Secondary accession number(s): P31975 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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