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Protein

Global nitrogen regulator

Gene

ntcA

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control.
Has affinity for the xisA upstream region. Binds to a 66 bp region containing three repeats of the consensus recognition sequence 5'-ACATT-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi176 – 195H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciAVAR240292:G7WH-7785-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Global nitrogen regulator
Alternative name(s):
DNA-binding protein VF1
Nitrogen-responsive regulatory protein
Gene namesi
Name:ntcA
Synonyms:bifA
Ordered Locus Names:Ava_3283
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeTrichormus
Proteomesi
  • UP000002533 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001001851 – 223Global nitrogen regulatorAdd BLAST223

Proteomic databases

PRIDEiP0A4U7

Interactioni

Protein-protein interaction databases

STRINGi240292.Ava_3283

Structurei

3D structure databases

ProteinModelPortaliP0A4U7
SMRiP0A4U7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 216HTH crp-typePROSITE-ProRule annotationAdd BLAST74

Phylogenomic databases

eggNOGiENOG4107RU9 Bacteria
ENOG410XVK4 LUCA
HOGENOMiHOG000232503
KOiK21561
OMAiTECEVAE
OrthoDBiPOG091H03PG

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di1.10.10.10, 1 hit
2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR012318 HTH_CRP
IPR014710 RmlC-like_jellyroll
IPR018335 Tscrpt_reg_HTH_Crp-type_CS
IPR022299 Tscrpt_reg_NtcA
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF13545 HTH_Crp_2, 1 hit
PRINTSiPR00034 HTHCRP
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SM00419 HTH_CRP, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF51206 SSF51206, 1 hit
TIGRFAMsiTIGR03697 NtcA_cyano, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS00042 HTH_CRP_1, 1 hit
PS51063 HTH_CRP_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0A4U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVTQDKALA NVFRQMATGA FPPVVETFER NKTIFFPGDP AERVYFLLKG
60 70 80 90 100
AVKLSRVYEA GEEITVALLR ENSVFGVLSL LTGNKSDRFY HAVAFTPVEL
110 120 130 140 150
LSAPIEQVEQ ALKENPELSM LMLRGLSSRI LQTEMMIETL AHRDMGSRLV
160 170 180 190 200
SFLLILCRDF GVPCADGITI DLKLSHQAIA EAIGSTRVTV TRLLGDLREK
210 220
KMISIHKKKI TVHKPVTLSR QFT
Length:223
Mass (Da):24,918
Last modified:March 15, 2005 - v1
Checksum:i07FCE891766E7021
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89516 Genomic DNA Translation: AAB49763.1
CP000117 Genomic DNA Translation: ABA22891.1
RefSeqiWP_010998529.1, NC_007413.1

Genome annotation databases

EnsemblBacteriaiABA22891; ABA22891; Ava_3283
KEGGiava:Ava_3283

Similar proteinsi

Entry informationi

Entry nameiNTCA_ANAVT
AccessioniPrimary (citable) accession number: P0A4U7
Secondary accession number(s): Q05061, Q3M7Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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