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P0A4U7 (NTCA_ANAVT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Global nitrogen regulator
Alternative name(s):
DNA-binding protein VF1
Nitrogen-responsive regulatory protein
Gene names
Name:ntcA
Synonyms:bifA
Ordered Locus Names:Ava_3283
OrganismAnabaena variabilis (strain ATCC 29413 / PCC 7937) [Complete proteome] [HAMAP]
Taxonomic identifier240292 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Function

Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control.

Has affinity for the xisA upstream region. Binds to a 66 bp region containing three repeats of the consensus recognition sequence 5'-ACATT-3'.

Sequence similarities

Contains 1 cyclic nucleotide-binding domain.

Contains 1 HTH crp-type DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 223223Global nitrogen regulator
PRO_0000100185

Regions

Domain143 – 21674HTH crp-type
DNA binding176 – 19520H-T-H motif By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A4U7 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 07FCE891766E7021

FASTA22324,918
        10         20         30         40         50         60 
MIVTQDKALA NVFRQMATGA FPPVVETFER NKTIFFPGDP AERVYFLLKG AVKLSRVYEA 

        70         80         90        100        110        120 
GEEITVALLR ENSVFGVLSL LTGNKSDRFY HAVAFTPVEL LSAPIEQVEQ ALKENPELSM 

       130        140        150        160        170        180 
LMLRGLSSRI LQTEMMIETL AHRDMGSRLV SFLLILCRDF GVPCADGITI DLKLSHQAIA 

       190        200        210        220 
EAIGSTRVTV TRLLGDLREK KMISIHKKKI TVHKPVTLSR QFT 

« Hide

References

« Hide 'large scale' references
[1]"Effect on heterocyst differentiation of nitrogen fixation in vegetative cells of the cyanobacterium Anabaena variabilis ATCC 29413."
Thiel T., Pratte B.
J. Bacteriol. 183:280-286(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequence of Anabaena variabilis ATCC 29413."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29413 / PCC 7937.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U89516 Genomic DNA. Translation: AAB49763.1.
CP000117 Genomic DNA. Translation: ABA22891.1.
RefSeqYP_323786.1. NC_007413.1.

3D structure databases

ProteinModelPortalP0A4U7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING240292.Ava_3283.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA22891; ABA22891; Ava_3283.
GeneID3680314.
KEGGava:Ava_3283.
PATRIC35427623. VBIAnaVar43351_4346.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0664.
HOGENOMHOG000232503.
OMAEERNDNE.
OrthoDBEOG6QRWC5.

Enzyme and pathway databases

BioCycAVAR240292:GCY3-3327-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSPR00034. HTHCRP.
SMARTSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMSSF51206. SSF51206. 1 hit.
TIGRFAMsTIGR03697. NtcA_cyano. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTCA_ANAVT
AccessionPrimary (citable) accession number: P0A4U7
Secondary accession number(s): Q05061, Q3M7Z5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families