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P0A4U7

- NTCA_ANAVT

UniProt

P0A4U7 - NTCA_ANAVT

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Protein

Global nitrogen regulator

Gene

ntcA

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control.
Has affinity for the xisA upstream region. Binds to a 66 bp region containing three repeats of the consensus recognition sequence 5'-ACATT-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi176 – 19520H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciAVAR240292:GCY3-3327-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Global nitrogen regulator
Alternative name(s):
DNA-binding protein VF1
Nitrogen-responsive regulatory protein
Gene namesi
Name:ntcA
Synonyms:bifA
Ordered Locus Names:Ava_3283
OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
Taxonomic identifieri240292 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
ProteomesiUP000002533: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Global nitrogen regulatorPRO_0000100185Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi240292.Ava_3283.

Structurei

3D structure databases

ProteinModelPortaliP0A4U7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 21674HTH crp-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000232503.
OMAiEERNDNE.
OrthoDBiEOG6QRWC5.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
TIGRFAMsiTIGR03697. NtcA_cyano. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A4U7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVTQDKALA NVFRQMATGA FPPVVETFER NKTIFFPGDP AERVYFLLKG
60 70 80 90 100
AVKLSRVYEA GEEITVALLR ENSVFGVLSL LTGNKSDRFY HAVAFTPVEL
110 120 130 140 150
LSAPIEQVEQ ALKENPELSM LMLRGLSSRI LQTEMMIETL AHRDMGSRLV
160 170 180 190 200
SFLLILCRDF GVPCADGITI DLKLSHQAIA EAIGSTRVTV TRLLGDLREK
210 220
KMISIHKKKI TVHKPVTLSR QFT
Length:223
Mass (Da):24,918
Last modified:March 15, 2005 - v1
Checksum:i07FCE891766E7021
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U89516 Genomic DNA. Translation: AAB49763.1.
CP000117 Genomic DNA. Translation: ABA22891.1.
RefSeqiYP_323786.1. NC_007413.1.

Genome annotation databases

EnsemblBacteriaiABA22891; ABA22891; Ava_3283.
GeneIDi3680314.
KEGGiava:Ava_3283.
PATRICi35427623. VBIAnaVar43351_4346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U89516 Genomic DNA. Translation: AAB49763.1 .
CP000117 Genomic DNA. Translation: ABA22891.1 .
RefSeqi YP_323786.1. NC_007413.1.

3D structure databases

ProteinModelPortali P0A4U7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 240292.Ava_3283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA22891 ; ABA22891 ; Ava_3283 .
GeneIDi 3680314.
KEGGi ava:Ava_3283.
PATRICi 35427623. VBIAnaVar43351_4346.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000232503.
OMAi EERNDNE.
OrthoDBi EOG6QRWC5.

Enzyme and pathway databases

BioCyci AVAR240292:GCY3-3327-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view ]
PRINTSi PR00034. HTHCRP.
SMARTi SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
TIGRFAMsi TIGR03697. NtcA_cyano. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Effect on heterocyst differentiation of nitrogen fixation in vegetative cells of the cyanobacterium Anabaena variabilis ATCC 29413."
    Thiel T., Pratte B.
    J. Bacteriol. 183:280-286(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of Anabaena variabilis ATCC 29413."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29413 / PCC 7937.

Entry informationi

Entry nameiNTCA_ANAVT
AccessioniPrimary (citable) accession number: P0A4U7
Secondary accession number(s): Q05061, Q3M7Z5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 1, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3