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P0A4U7

- NTCA_ANAVT

UniProt

P0A4U7 - NTCA_ANAVT

Protein

Global nitrogen regulator

Gene

ntcA

Organism
Anabaena variabilis (strain ATCC 29413 / PCC 7937)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control.
    Has affinity for the xisA upstream region. Binds to a 66 bp region containing three repeats of the consensus recognition sequence 5'-ACATT-3'.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi176 – 19520H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciAVAR240292:GCY3-3327-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Global nitrogen regulator
    Alternative name(s):
    DNA-binding protein VF1
    Nitrogen-responsive regulatory protein
    Gene namesi
    Name:ntcA
    Synonyms:bifA
    Ordered Locus Names:Ava_3283
    OrganismiAnabaena variabilis (strain ATCC 29413 / PCC 7937)
    Taxonomic identifieri240292 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeAnabaena
    ProteomesiUP000002533: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 223223Global nitrogen regulatorPRO_0000100185Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi240292.Ava_3283.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A4U7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini143 – 21674HTH crp-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
    Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000232503.
    OMAiEERNDNE.
    OrthoDBiEOG6QRWC5.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR022299. Tscrpt_reg_NtcA.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    PF00325. Crp. 1 hit.
    [Graphical view]
    PRINTSiPR00034. HTHCRP.
    SMARTiSM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    TIGRFAMsiTIGR03697. NtcA_cyano. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
    PS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A4U7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIVTQDKALA NVFRQMATGA FPPVVETFER NKTIFFPGDP AERVYFLLKG    50
    AVKLSRVYEA GEEITVALLR ENSVFGVLSL LTGNKSDRFY HAVAFTPVEL 100
    LSAPIEQVEQ ALKENPELSM LMLRGLSSRI LQTEMMIETL AHRDMGSRLV 150
    SFLLILCRDF GVPCADGITI DLKLSHQAIA EAIGSTRVTV TRLLGDLREK 200
    KMISIHKKKI TVHKPVTLSR QFT 223
    Length:223
    Mass (Da):24,918
    Last modified:March 15, 2005 - v1
    Checksum:i07FCE891766E7021
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89516 Genomic DNA. Translation: AAB49763.1.
    CP000117 Genomic DNA. Translation: ABA22891.1.
    RefSeqiYP_323786.1. NC_007413.1.

    Genome annotation databases

    EnsemblBacteriaiABA22891; ABA22891; Ava_3283.
    GeneIDi3680314.
    KEGGiava:Ava_3283.
    PATRICi35427623. VBIAnaVar43351_4346.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U89516 Genomic DNA. Translation: AAB49763.1 .
    CP000117 Genomic DNA. Translation: ABA22891.1 .
    RefSeqi YP_323786.1. NC_007413.1.

    3D structure databases

    ProteinModelPortali P0A4U7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 240292.Ava_3283.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA22891 ; ABA22891 ; Ava_3283 .
    GeneIDi 3680314.
    KEGGi ava:Ava_3283.
    PATRICi 35427623. VBIAnaVar43351_4346.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000232503.
    OMAi EERNDNE.
    OrthoDBi EOG6QRWC5.

    Enzyme and pathway databases

    BioCyci AVAR240292:GCY3-3327-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR001808. Tscrpt_reg_HTH_Crp.
    IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
    IPR022299. Tscrpt_reg_NtcA.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    PF00325. Crp. 1 hit.
    [Graphical view ]
    PRINTSi PR00034. HTHCRP.
    SMARTi SM00100. cNMP. 1 hit.
    SM00419. HTH_CRP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    TIGRFAMsi TIGR03697. NtcA_cyano. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
    PS00042. HTH_CRP_1. 1 hit.
    PS51063. HTH_CRP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Effect on heterocyst differentiation of nitrogen fixation in vegetative cells of the cyanobacterium Anabaena variabilis ATCC 29413."
      Thiel T., Pratte B.
      J. Bacteriol. 183:280-286(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequence of Anabaena variabilis ATCC 29413."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyrpides N., Mavrommatis K., Richardson P.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29413 / PCC 7937.

    Entry informationi

    Entry nameiNTCA_ANAVT
    AccessioniPrimary (citable) accession number: P0A4U7
    Secondary accession number(s): Q05061, Q3M7Z5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3