Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Global nitrogen regulator

Gene

ntcA

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control.
Has affinity for the xisA upstream region. Binds to a 66 bp region containing three repeats of the consensus recognition sequence 5'-ACATT-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi176 – 195H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Global nitrogen regulator
Alternative name(s):
DNA-binding protein VF1
Nitrogen-responsive regulatory protein
Gene namesi
Name:ntcA
Synonyms:bifA
Ordered Locus Names:alr4392
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001001841 – 223Global nitrogen regulatorAdd BLAST223

Expressioni

Gene expression databases

CollecTFiEXPREG_00000760.

Interactioni

Protein-protein interaction databases

DIPiDIP-59350N.
STRINGi103690.alr4392.

Structurei

Secondary structure

1223
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 16Combined sources10
Beta strandi24 – 28Combined sources5
Beta strandi33 – 35Combined sources3
Beta strandi43 – 50Combined sources8
Beta strandi52 – 57Combined sources6
Beta strandi63 – 69Combined sources7
Beta strandi74 – 76Combined sources3
Helixi78 – 81Combined sources4
Helixi83 – 85Combined sources3
Beta strandi90 – 104Combined sources15
Helixi105 – 112Combined sources8
Helixi116 – 141Combined sources26
Helixi145 – 160Combined sources16
Beta strandi161 – 163Combined sources3
Beta strandi165 – 170Combined sources6
Helixi176 – 183Combined sources8
Helixi187 – 199Combined sources13
Beta strandi202 – 206Combined sources5
Beta strandi209 – 212Combined sources4
Helixi215 – 218Combined sources4
Turni219 – 221Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LA2X-ray2.60A/B1-223[»]
3LA3X-ray2.40A/B1-223[»]
3LA7X-ray1.90A/B1-223[»]
ProteinModelPortaliP0A4U6.
SMRiP0A4U6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A4U6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 216HTH crp-typePROSITE-ProRule annotationAdd BLAST74

Phylogenomic databases

eggNOGiENOG4107RU9. Bacteria.
ENOG410XVK4. LUCA.
HOGENOMiHOG000232503.
OMAiFTRVEMI.
OrthoDBiPOG090100I7.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiView protein in InterPro
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00027. cNMP_binding. 1 hit.
PF13545. HTH_Crp_2. 1 hit.
PRINTSiPR00034. HTHCRP.
SMARTiView protein in SMART
SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51206. SSF51206. 1 hit.
TIGRFAMsiTIGR03697. NtcA_cyano. 1 hit.
PROSITEiView protein in PROSITE
PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A4U6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVTQDKALA NVFRQMATGA FPPVVETFER NKTIFFPGDP AERVYFLLKG
60 70 80 90 100
AVKLSRVYEA GEEITVALLR ENSVFGVLSL LTGNKSDRFY HAVAFTPVEL
110 120 130 140 150
LSAPIEQVEQ ALKENPELSM LMLRGLSSRI LQTEMMIETL AHRDMGSRLV
160 170 180 190 200
SFLLILCRDF GVPCADGITI DLKLSHQAIA EAIGSTRVTV TRLLGDLREK
210 220
KMISIHKKKI TVHKPVTLSR QFT
Length:223
Mass (Da):24,918
Last modified:March 15, 2005 - v1
Checksum:i07FCE891766E7021
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10036 Genomic DNA. Translation: AAD04183.1.
X71608 Genomic DNA. Translation: CAA50608.1.
BA000019 Genomic DNA. Translation: BAB76091.1.
PIRiAH2354.
B48640.
RefSeqiWP_010998529.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB76091; BAB76091; BAB76091.
KEGGiana:alr4392.
PATRICi22779368. VBINosSp37423_5131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10036 Genomic DNA. Translation: AAD04183.1.
X71608 Genomic DNA. Translation: CAA50608.1.
BA000019 Genomic DNA. Translation: BAB76091.1.
PIRiAH2354.
B48640.
RefSeqiWP_010998529.1. NC_003272.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LA2X-ray2.60A/B1-223[»]
3LA3X-ray2.40A/B1-223[»]
3LA7X-ray1.90A/B1-223[»]
ProteinModelPortaliP0A4U6.
SMRiP0A4U6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59350N.
STRINGi103690.alr4392.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB76091; BAB76091; BAB76091.
KEGGiana:alr4392.
PATRICi22779368. VBINosSp37423_5131.

Phylogenomic databases

eggNOGiENOG4107RU9. Bacteria.
ENOG410XVK4. LUCA.
HOGENOMiHOG000232503.
OMAiFTRVEMI.
OrthoDBiPOG090100I7.

Miscellaneous databases

EvolutionaryTraceiP0A4U6.

Gene expression databases

CollecTFiEXPREG_00000760.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiView protein in InterPro
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP.
IPR014710. RmlC-like_jellyroll.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00027. cNMP_binding. 1 hit.
PF13545. HTH_Crp_2. 1 hit.
PRINTSiPR00034. HTHCRP.
SMARTiView protein in SMART
SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF51206. SSF51206. 1 hit.
TIGRFAMsiTIGR03697. NtcA_cyano. 1 hit.
PROSITEiView protein in PROSITE
PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNTCA_NOSS1
AccessioniPrimary (citable) accession number: P0A4U6
Secondary accession number(s): Q05061
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: February 15, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.