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P0A4U6

- NTCA_NOSS1

UniProt

P0A4U6 - NTCA_NOSS1

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Protein

Global nitrogen regulator

Gene

ntcA

Organism
Nostoc sp. (strain PCC 7120 / UTEX 2576)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Required for full expression of proteins subject to ammonium repression. Transcriptional activator of genes subject to nitrogen control.
Has affinity for the xisA upstream region. Binds to a 66 bp region containing three repeats of the consensus recognition sequence 5'-ACATT-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi176 – 19520H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Global nitrogen regulator
Alternative name(s):
DNA-binding protein VF1
Nitrogen-responsive regulatory protein
Gene namesi
Name:ntcA
Synonyms:bifA
Ordered Locus Names:alr4392
OrganismiNostoc sp. (strain PCC 7120 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
ProteomesiUP000002483: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223Global nitrogen regulatorPRO_0000100184Add
BLAST

Interactioni

Protein-protein interaction databases

DIPiDIP-59350N.
STRINGi103690.alr4392.

Structurei

Secondary structure

1
223
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 1610Combined sources
Beta strandi24 – 285Combined sources
Beta strandi33 – 353Combined sources
Beta strandi43 – 508Combined sources
Beta strandi52 – 576Combined sources
Beta strandi63 – 697Combined sources
Beta strandi74 – 763Combined sources
Helixi78 – 814Combined sources
Helixi83 – 853Combined sources
Beta strandi90 – 10415Combined sources
Helixi105 – 1128Combined sources
Helixi116 – 14126Combined sources
Helixi145 – 16016Combined sources
Beta strandi161 – 1633Combined sources
Beta strandi165 – 1706Combined sources
Helixi176 – 1838Combined sources
Helixi187 – 19913Combined sources
Beta strandi202 – 2065Combined sources
Beta strandi209 – 2124Combined sources
Helixi215 – 2184Combined sources
Turni219 – 2213Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LA2X-ray2.60A/B1-223[»]
3LA3X-ray2.40A/B1-223[»]
3LA7X-ray1.90A/B1-223[»]
ProteinModelPortaliP0A4U6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A4U6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 21674HTH crp-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 cyclic nucleotide-binding domain.PROSITE-ProRule annotation
Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0664.
HOGENOMiHOG000232503.
OMAiYHSVAFT.
OrthoDBiEOG6QRWC5.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProiIPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view]
PRINTSiPR00034. HTHCRP.
SMARTiSM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
TIGRFAMsiTIGR03697. NtcA_cyano. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A4U6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIVTQDKALA NVFRQMATGA FPPVVETFER NKTIFFPGDP AERVYFLLKG
60 70 80 90 100
AVKLSRVYEA GEEITVALLR ENSVFGVLSL LTGNKSDRFY HAVAFTPVEL
110 120 130 140 150
LSAPIEQVEQ ALKENPELSM LMLRGLSSRI LQTEMMIETL AHRDMGSRLV
160 170 180 190 200
SFLLILCRDF GVPCADGITI DLKLSHQAIA EAIGSTRVTV TRLLGDLREK
210 220
KMISIHKKKI TVHKPVTLSR QFT
Length:223
Mass (Da):24,918
Last modified:March 15, 2005 - v1
Checksum:i07FCE891766E7021
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10036 Genomic DNA. Translation: AAD04183.1.
X71608 Genomic DNA. Translation: CAA50608.1.
BA000019 Genomic DNA. Translation: BAB76091.1.
PIRiAH2354.
B48640.
RefSeqiNP_488432.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB76091; BAB76091; BAB76091.
GeneIDi1107993.
KEGGiana:alr4392.
PATRICi22779368. VBINosSp37423_5131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10036 Genomic DNA. Translation: AAD04183.1 .
X71608 Genomic DNA. Translation: CAA50608.1 .
BA000019 Genomic DNA. Translation: BAB76091.1 .
PIRi AH2354.
B48640.
RefSeqi NP_488432.1. NC_003272.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3LA2 X-ray 2.60 A/B 1-223 [» ]
3LA3 X-ray 2.40 A/B 1-223 [» ]
3LA7 X-ray 1.90 A/B 1-223 [» ]
ProteinModelPortali P0A4U6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-59350N.
STRINGi 103690.alr4392.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB76091 ; BAB76091 ; BAB76091 .
GeneIDi 1107993.
KEGGi ana:alr4392.
PATRICi 22779368. VBINosSp37423_5131.

Phylogenomic databases

eggNOGi COG0664.
HOGENOMi HOG000232503.
OMAi YHSVAFT.
OrthoDBi EOG6QRWC5.

Miscellaneous databases

EvolutionaryTracei P0A4U6.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.60.120.10. 1 hit.
InterProi IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR012318. HTH_CRP_2.
IPR014710. RmlC-like_jellyroll.
IPR001808. Tscrpt_reg_HTH_Crp.
IPR018335. Tscrpt_reg_HTH_Crp-type_CS.
IPR022299. Tscrpt_reg_NtcA.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00027. cNMP_binding. 1 hit.
PF00325. Crp. 1 hit.
[Graphical view ]
PRINTSi PR00034. HTHCRP.
SMARTi SM00100. cNMP. 1 hit.
SM00419. HTH_CRP. 1 hit.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 1 hit.
TIGRFAMsi TIGR03697. NtcA_cyano. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 1 hit.
PS00042. HTH_CRP_1. 1 hit.
PS51063. HTH_CRP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Anabaena sp. strain PCC 7120 bifA gene encoding a sequence-specific DNA-binding protein cloned by in vivo transcriptional interference selection."
    Wei T.-F., Ramasubramanian T.S., Pu F., Golden J.W.
    J. Bacteriol. 175:4025-4035(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "General distribution of the nitrogen control gene ntcA in cyanobacteria."
    Frias J.E., Merida A., Herrero A., Martin-Nieto J.M., Flores E.
    J. Bacteriol. 175:5710-5713(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7120 / UTEX 2576.

Entry informationi

Entry nameiNTCA_NOSS1
AccessioniPrimary (citable) accession number: P0A4U6
Secondary accession number(s): Q05061
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3