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Protein

Cadmium resistance transcriptional regulatory protein CadC

Gene

cadC

Organism
Lactococcus lactis subsp. lactis (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Metal-binding repressor for the cad operon. Involved in resistance to heavy metals, such as cadmium, bismuth, zinc or lead. Metal binding causes the repressor to dissociate from the DNA (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi6 – 61Cadmium; shared with dimeric partnerPROSITE-ProRule annotation
Metal bindingi10 – 101Cadmium; shared with dimeric partnerPROSITE-ProRule annotation
Metal bindingi57 – 571Cadmium; shared with dimeric partnerPROSITE-ProRule annotation
Metal bindingi59 – 591Cadmium; shared with dimeric partnerPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi58 – 7720H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. response to cadmium ion Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cadmium resistance, Transcription, Transcription regulation

Keywords - Ligandi

Cadmium, DNA-binding, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadmium resistance transcriptional regulatory protein CadC
Alternative name(s):
Cadmium efflux system accessory protein
Gene namesi
Name:cadC
Encoded oniPlasmid pND3021 Publication
Plasmid pAH821 Publication
OrganismiLactococcus lactis subsp. lactis (Streptococcus lactis)
Taxonomic identifieri1360 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 119119Cadmium resistance transcriptional regulatory protein CadCPRO_0000160617Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP0A4U3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 11896HTH arsR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH arsR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000144506.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR018334. ArsR_HTH.
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
PROSITEiPS00846. HTH_ARSR_1. 1 hit.
PS50987. HTH_ARSR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A4U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNEICEITC IHEDKVNRAK SKLANFDTPS VSGFFKILSD ENRLKIVHAL
60 70 80 90 100
VHEDELCVCD IANIIDASVA TTSHHLNSLK KLGVVDSHKD GKLVYYFIKN
110
IKILNLMELG VNFKEEVLA
Length:119
Mass (Da):13,382
Last modified:March 14, 2005 - v1
Checksum:iB34C01C21DC2C944
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78967 Genomic DNA. Translation: AAB37344.1.
AF243383 Genomic DNA. Translation: AAF98301.1.
RefSeqiNP_862601.1. NC_004966.1.
YP_001174713.1. NC_009435.1.
YP_001966470.1. NC_010901.1.
YP_004761536.1. NC_015863.1.
YP_009074918.1. NG_034799.1.

Genome annotation databases

GeneIDi11013250.
3125820.
5077334.
6385740.
KEGGipg:11013250.
pg:3125820.
pg:5077334.
pg:6385740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78967 Genomic DNA. Translation: AAB37344.1.
AF243383 Genomic DNA. Translation: AAF98301.1.
RefSeqiNP_862601.1. NC_004966.1.
YP_001174713.1. NC_009435.1.
YP_001966470.1. NC_010901.1.
YP_004761536.1. NC_015863.1.
YP_009074918.1. NG_034799.1.

3D structure databases

ProteinModelPortaliP0A4U3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi11013250.
3125820.
5077334.
6385740.
KEGGipg:11013250.
pg:3125820.
pg:5077334.
pg:6385740.

Phylogenomic databases

HOGENOMiHOG000144506.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR018334. ArsR_HTH.
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
PROSITEiPS00846. HTH_ARSR_1. 1 hit.
PS50987. HTH_ARSR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genetic analysis of regions involved in replication and cadmium resistance of the plasmid pND302 from Lactococcus lactis."
    Liu C.-Q., Khunajakr N., Chia L.G., Deng Y.-M., Charoenchai P., Dunn N.W.
    Plasmid 38:79-90(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: M71.
    Plasmid: pND302
  2. "Novel type I restriction specificities through domain shuffling of HsdS subunits in Lactococcus lactis."
    O'Sullivan D., Twomey D.P., Coffey A., Hill C., Fitzgerald G.F., Ross P.R.
    Mol. Microbiol. 36:866-875(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DPC220.
    Plasmid: pAH82

Entry informationi

Entry nameiCADC_LACLL
AccessioniPrimary (citable) accession number: P0A4U3
Secondary accession number(s): P94887
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 14, 2005
Last sequence update: March 14, 2005
Last modified: March 31, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.