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P0A4U3 (CADC_LACLL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cadmium resistance transcriptional regulatory protein CadC
Alternative name(s):
Cadmium efflux system accessory protein
Gene names
Name:cadC
Encoded onPlasmid pND302 Ref.1
Plasmid pAH82 Ref.2
OrganismLactococcus lactis subsp. lactis (Streptococcus lactis)
Taxonomic identifier1360 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length119 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Metal-binding repressor for the cad operon. Involved in resistance to heavy metals, such as cadmium, bismuth, zinc or lead. Metal binding causes the repressor to dissociate from the DNA By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Contains 1 HTH arsR-type DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 119119Cadmium resistance transcriptional regulatory protein CadC
PRO_0000160617

Regions

Domain23 – 11896HTH arsR-type
DNA binding58 – 7720H-T-H motif By similarity

Sites

Metal binding61Cadmium; shared with dimeric partner By similarity
Metal binding101Cadmium; shared with dimeric partner By similarity
Metal binding571Cadmium; shared with dimeric partner By similarity
Metal binding591Cadmium; shared with dimeric partner By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A4U3 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: B34C01C21DC2C944

FASTA11913,382
        10         20         30         40         50         60 
MNNEICEITC IHEDKVNRAK SKLANFDTPS VSGFFKILSD ENRLKIVHAL VHEDELCVCD 

        70         80         90        100        110 
IANIIDASVA TTSHHLNSLK KLGVVDSHKD GKLVYYFIKN IKILNLMELG VNFKEEVLA 

« Hide

References

[1]"Genetic analysis of regions involved in replication and cadmium resistance of the plasmid pND302 from Lactococcus lactis."
Liu C.-Q., Khunajakr N., Chia L.G., Deng Y.-M., Charoenchai P., Dunn N.W.
Plasmid 38:79-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: M71.
[2]"Novel type I restriction specificities through domain shuffling of HsdS subunits in Lactococcus lactis."
O'Sullivan D., Twomey D.P., Coffey A., Hill C., Fitzgerald G.F., Ross P.R.
Mol. Microbiol. 36:866-875(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: DPC220.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U78967 Genomic DNA. Translation: AAB37344.1.
AF243383 Genomic DNA. Translation: AAF98301.1.
RefSeqNP_862601.1. NC_004966.1.
YP_001174713.1. NC_009435.1.
YP_001966470.1. NC_010901.1.
YP_004761536.1. NC_015863.1.

3D structure databases

ProteinModelPortalP0A4U3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID11013250.
3125820.
5077334.
6385740.

Phylogenomic databases

HOGENOMHOG000144506.
ProtClustDBCLSK811323.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR018334. ArsR_HTH.
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSPR00778. HTHARSR.
SMARTSM00418. HTH_ARSR. 1 hit.
[Graphical view]
PROSITEPS00846. HTH_ARSR_1. 1 hit.
PS50987. HTH_ARSR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCADC_LACLL
AccessionPrimary (citable) accession number: P0A4U3
Secondary accession number(s): P94887
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families