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P0A4U3

- CADC_LACLL

UniProt

P0A4U3 - CADC_LACLL

Protein

Cadmium resistance transcriptional regulatory protein CadC

Gene

cadC

Organism
Lactococcus lactis subsp. lactis (Streptococcus lactis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Metal-binding repressor for the cad operon. Involved in resistance to heavy metals, such as cadmium, bismuth, zinc or lead. Metal binding causes the repressor to dissociate from the DNA By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi6 – 61Cadmium; shared with dimeric partnerPROSITE-ProRule annotation
    Metal bindingi10 – 101Cadmium; shared with dimeric partnerPROSITE-ProRule annotation
    Metal bindingi57 – 571Cadmium; shared with dimeric partnerPROSITE-ProRule annotation
    Metal bindingi59 – 591Cadmium; shared with dimeric partnerPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi58 – 7720H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. response to cadmium ion Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Cadmium resistance, Transcription, Transcription regulation

    Keywords - Ligandi

    Cadmium, DNA-binding, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadmium resistance transcriptional regulatory protein CadC
    Alternative name(s):
    Cadmium efflux system accessory protein
    Gene namesi
    Name:cadC
    Encoded oniPlasmid pND3021 Publication
    Plasmid pAH821 Publication
    OrganismiLactococcus lactis subsp. lactis (Streptococcus lactis)
    Taxonomic identifieri1360 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 119119Cadmium resistance transcriptional regulatory protein CadCPRO_0000160617Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP0A4U3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 11896HTH arsR-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH arsR-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000144506.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR018334. ArsR_HTH.
    IPR001845. HTH_ArsR_DNA-bd_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF01022. HTH_5. 1 hit.
    [Graphical view]
    PRINTSiPR00778. HTHARSR.
    SMARTiSM00418. HTH_ARSR. 1 hit.
    [Graphical view]
    PROSITEiPS00846. HTH_ARSR_1. 1 hit.
    PS50987. HTH_ARSR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A4U3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNEICEITC IHEDKVNRAK SKLANFDTPS VSGFFKILSD ENRLKIVHAL    50
    VHEDELCVCD IANIIDASVA TTSHHLNSLK KLGVVDSHKD GKLVYYFIKN 100
    IKILNLMELG VNFKEEVLA 119
    Length:119
    Mass (Da):13,382
    Last modified:March 15, 2005 - v1
    Checksum:iB34C01C21DC2C944
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78967 Genomic DNA. Translation: AAB37344.1.
    AF243383 Genomic DNA. Translation: AAF98301.1.
    RefSeqiNP_862601.1. NC_004966.1.
    YP_001174713.1. NC_009435.1.
    YP_001966470.1. NC_010901.1.
    YP_004761536.1. NC_015863.1.

    Genome annotation databases

    GeneIDi11013250.
    3125820.
    5077334.
    6385740.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78967 Genomic DNA. Translation: AAB37344.1 .
    AF243383 Genomic DNA. Translation: AAF98301.1 .
    RefSeqi NP_862601.1. NC_004966.1.
    YP_001174713.1. NC_009435.1.
    YP_001966470.1. NC_010901.1.
    YP_004761536.1. NC_015863.1.

    3D structure databases

    ProteinModelPortali P0A4U3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 11013250.
    3125820.
    5077334.
    6385740.

    Phylogenomic databases

    HOGENOMi HOG000144506.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR018334. ArsR_HTH.
    IPR001845. HTH_ArsR_DNA-bd_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF01022. HTH_5. 1 hit.
    [Graphical view ]
    PRINTSi PR00778. HTHARSR.
    SMARTi SM00418. HTH_ARSR. 1 hit.
    [Graphical view ]
    PROSITEi PS00846. HTH_ARSR_1. 1 hit.
    PS50987. HTH_ARSR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic analysis of regions involved in replication and cadmium resistance of the plasmid pND302 from Lactococcus lactis."
      Liu C.-Q., Khunajakr N., Chia L.G., Deng Y.-M., Charoenchai P., Dunn N.W.
      Plasmid 38:79-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: M71.
      Plasmid: pND302
    2. "Novel type I restriction specificities through domain shuffling of HsdS subunits in Lactococcus lactis."
      O'Sullivan D., Twomey D.P., Coffey A., Hill C., Fitzgerald G.F., Ross P.R.
      Mol. Microbiol. 36:866-875(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DPC220.
      Plasmid: pAH82

    Entry informationi

    Entry nameiCADC_LACLL
    AccessioniPrimary (citable) accession number: P0A4U3
    Secondary accession number(s): P94887
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Plasmid

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3