tipA

Functionⁱ

Transcriptional activator. Is activated when bound to the antibiotic thiostrepton.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	5 – 24	H-T-H motifPROSITE-ProRule annotationAdd BLAST		20

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: UniProtKB-KW
transcription, DNA-templated Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: HTH-type transcriptional activator TipA
Gene namesⁱ	Name:tipA
Organismⁱ	Streptomyces lividans
Taxonomic identifierⁱ	1916 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Actinobacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000013606	1 – 253	HTH-type transcriptional activator TipAAdd BLAST		253

Interactionⁱ

Subunit structureⁱ

Homodimer.Curated

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	5 – 12	Combined sources	8
Helixⁱ	16 – 24	Combined sources	9
Beta strandⁱ	31 – 33	Combined sources	3
Beta strandⁱ	39 – 41	Combined sources	3
Helixⁱ	43 – 57	Combined sources	15
Helixⁱ	62 – 69	Combined sources	8
Helixⁱ	79 – 105	Combined sources	27
Helixⁱ	116 – 123	Combined sources	8
Helixⁱ	129 – 131	Combined sources	3
Helixⁱ	132 – 138	Combined sources	7
Helixⁱ	144 – 152	Combined sources	9
Helixⁱ	165 – 180	Combined sources	16
Helixⁱ	187 – 203	Combined sources	17
Helixⁱ	209 – 218	Combined sources	10
Helixⁱ	223 – 229	Combined sources	7
Helixⁱ	230 – 232	Combined sources	3
Beta strandⁱ	233 – 235	Combined sources	3
Helixⁱ	236 – 251	Combined sources	16

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1NY9	NMR	-	A	111-253	[»]
	2MBZ	NMR	-	A	110-253	[»]
	2MC0	NMR	-	A	110-253	[»]
	2VZ4	X-ray	2.90	A	2-109	[»]
Database of protein disorder More...DisProtⁱ	DP00997.
ProteinModelPortalⁱ	P0A4T9.
SMRⁱ	P0A4T9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P0A4T9.

EvolutionaryTraceⁱ

P0A4T9.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 71	HTH merR-typePROSITE-ProRule annotationAdd BLAST		71

Family and domain databases

InterProⁱ	View protein in InterPro IPR009061. DNA-bd_dom_put. IPR000551. MerR-type_HTH_dom. IPR012925. TipAS_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13411. MerR_1. 1 hit. PF07739. TipAS. 1 hit.
PRINTSⁱ	PR00040. HTHMERR.
SMARTⁱ	View protein in SMART SM00422. HTH_MERR. 1 hit.
SUPFAMⁱ	SSF46955. SSF46955. 1 hit. SSF89082. SSF89082. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00552. HTH_MERR_1. 1 hit. PS50937. HTH_MERR_2. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative initiation. Align Add to basket Added to basket

Isoform Long (identifier: P0A4T9-1) [UniParc]FASTA Add to basket

Also known as: TipA-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYSVGQVAG FAGVTVRTLH HYDDIGLLVP SERSHAGHRR YSDADLDRLQ 
        60         70         80         90        100
QILFYRELGF PLDEVAALLD DPAADPRAHL RRQHELLSAR IGKLQKMAAA 
       110        120        130        140        150
VEQAMEARSM GINLTPEEKF EVFGDFDPDQ YEEEVRERWG NTDAYRQSKE 
       160        170        180        190        200
KTASYTKEDW QRIQDEADEL TRRFVALMDA GEPADSEGAM DAAEDHRQGI 
       210        220        230        240        250
ARNHYDCGYE MHTCLGEMYV SDERFTRNID AAKPGLAAYM RDAILANAVR 

HTP

Length:253

Mass (Da):28,711

Last modified:March 15, 2005 - v1

Checksum:ⁱ0B32F6191BF2B779

GO

Isoform Short (identifier: P0A4T9-2) [UniParc]FASTA Add to basket

Also known as: TipA-S

The sequence of this isoform differs from the canonical sequence as follows:
1-109: Missing.

« Hide

        10         20         30         40         50
MGINLTPEEK FEVFGDFDPD QYEEEVRERW GNTDAYRQSK EKTASYTKED 
        60         70         80         90        100
WQRIQDEADE LTRRFVALMD AGEPADSEGA MDAAEDHRQG IARNHYDCGY 
       110        120        130        140 
EMHTCLGEMY VSDERFTRNI DAAKPGLAAY MRDAILANAV RHTP

Show »

Length:144

Mass (Da):16,563

Checksum:ⁱ11092740A7B10FDA

GO

Sequence cautionⁱ

The sequence AAC13653 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_018752	1 – 109	Missing in isoform Short. CuratedAdd BLAST		109

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S64314 Genomic DNA. Translation: AAB27737.1. M24524 Genomic DNA. Translation: AAC13653.1. Different initiation.
PIRⁱ	S35354.

Keywords - Coding sequence diversityⁱ

Alternative initiation

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S64314 Genomic DNA. Translation: AAB27737.1. M24524 Genomic DNA. Translation: AAC13653.1. Different initiation.
PIRⁱ	S35354.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1NY9	NMR	-	A	111-253	[»]
	2MBZ	NMR	-	A	110-253	[»]
	2MC0	NMR	-	A	110-253	[»]
	2VZ4	X-ray	2.90	A	2-109	[»]
Database of protein disorder More...DisProtⁱ	DP00997.
ProteinModelPortalⁱ	P0A4T9.
SMRⁱ	P0A4T9.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P0A4T9.

EvolutionaryTraceⁱ

P0A4T9.

Family and domain databases

InterProⁱ	View protein in InterPro IPR009061. DNA-bd_dom_put. IPR000551. MerR-type_HTH_dom. IPR012925. TipAS_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13411. MerR_1. 1 hit. PF07739. TipAS. 1 hit.
PRINTSⁱ	PR00040. HTHMERR.
SMARTⁱ	View protein in SMART SM00422. HTH_MERR. 1 hit.
SUPFAMⁱ	SSF46955. SSF46955. 1 hit. SSF89082. SSF89082. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00552. HTH_MERR_1. 1 hit. PS50937. HTH_MERR_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TIPA_STRLI
Accessionⁱ	P0A4T9Primary (citable) accession number: P0A4T9 Secondary accession number(s): P32184
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
	Last sequence update:	March 15, 2005
	Last modified:	May 10, 2017
	This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB - P0A4T9 (TIPA_STRLI)

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HTH-type transcriptional activator TipA

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Functionⁱ

Regions

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Molecule processing

Interactionⁱ

Subunit structureⁱ

Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

Family & Domainsⁱ

Domains and Repeats

Family and domain databases

Sequences (2)ⁱ

Sequence cautionⁱ

Alternative sequence

Sequence databases

Keywords - Coding sequence diversityⁱ

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Miscellaneous databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0A4T9 (TIPA_STRLI)

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HTH-type transcriptional activator TipA

tipA

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequences (2)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ