tipA

Functionⁱ

Transcriptional activator. Is activated when bound to the antibiotic thiostrepton.

Regions

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
DNA bindingⁱ	5 – 24	20	H-T-H motifPROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00254			Add BLAST

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: HTH-type transcriptional activator TipA
Gene namesⁱ	Name:tipA
Organismⁱ	Streptomyces lividans
Taxonomic identifierⁱ	1916 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Actinobacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 253	253	HTH-type transcriptional activator TipA		PRO_0000013606	Add BLAST

Interactionⁱ

Subunit structureⁱ

Homodimer.Curated

Structureⁱ

Secondary structure

1

253

Legend: HelixTurnBeta strand

Show more details

Feature key	Position(s)	Length	Description
Helixⁱ	5 – 12	8	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2VZ4
Helixⁱ	16 – 24	9	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2VZ4
Beta strandⁱ	31 – 33	3	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2VZ4
Beta strandⁱ	39 – 41	3	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2VZ4
Helixⁱ	43 – 57	15	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2VZ4
Helixⁱ	62 – 69	8	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2VZ4
Helixⁱ	79 – 105	27	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2VZ4
Helixⁱ	116 – 123	8	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2MBZ
Helixⁱ	129 – 131	3	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2MBZ
Helixⁱ	132 – 138	7	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2MBZ
Helixⁱ	144 – 152	9	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2MBZ
Helixⁱ	165 – 180	16	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:1NY9
Helixⁱ	187 – 203	17	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:1NY9
Helixⁱ	209 – 218	10	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:1NY9
Helixⁱ	223 – 229	7	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:1NY9
Helixⁱ	230 – 232	3	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:1NY9
Beta strandⁱ	233 – 235	3	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2MC0
Helixⁱ	236 – 251	16	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:1NY9

3D structure databases

Select the link destinations:
PDBeⁱ
RCSB PDBⁱ
PDBjⁱ

Links Updated

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1NY9	NMR	-	A	111-253	[»]
2MBZ	NMR	-	A	110-253	[»]
2MC0	NMR	-	A	110-253	[»]
2VZ4	X-ray	2.90	A	2-109	[»]

ProteinModelPortalⁱ

P0A4T9.

SMRⁱ

P0A4T9. Positions 160-253.

ModBaseⁱ

Search...

MobiDBⁱ

Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P0A4T9.

EvolutionaryTraceⁱ

P0A4T9.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Domainⁱ	1 – 71	71	HTH merR-typePROSITE-ProRule annotation Manual assertion according to rulesⁱ PROSITE-ProRule:PRU00254			Add BLAST

Sequence similaritiesⁱ

Contains 1 HTH merR-type DNA-binding domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Dⁱ	1.10.490.50. 1 hit.
InterProⁱ	IPR009061. DNA-bd_dom_put. IPR000551. MerR-type_HTH_dom. IPR012925. TipAS_dom. [Graphical view]
Pfamⁱ	PF13411. MerR_1. 1 hit. PF07739. TipAS. 1 hit. [Graphical view]
PRINTSⁱ	PR00040. HTHMERR.
SMARTⁱ	SM00422. HTH_MERR. 1 hit. [Graphical view]
SUPFAMⁱ	SSF46955. SSF46955. 1 hit. SSF89082. SSF89082. 1 hit.
PROSITEⁱ	PS00552. HTH_MERR_1. 1 hit. PS50937. HTH_MERR_2. 1 hit. [Graphical view]

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative initiation. Align Add to basket Added to basket

Isoform Long (identifier: P0A4T9-1) [UniParc]FASTA Add to basket

Also known as: TipA-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYSVGQVAG FAGVTVRTLH HYDDIGLLVP SERSHAGHRR YSDADLDRLQ 
        60         70         80         90        100
QILFYRELGF PLDEVAALLD DPAADPRAHL RRQHELLSAR IGKLQKMAAA 
       110        120        130        140        150
VEQAMEARSM GINLTPEEKF EVFGDFDPDQ YEEEVRERWG NTDAYRQSKE 
       160        170        180        190        200
KTASYTKEDW QRIQDEADEL TRRFVALMDA GEPADSEGAM DAAEDHRQGI 
       210        220        230        240        250
ARNHYDCGYE MHTCLGEMYV SDERFTRNID AAKPGLAAYM RDAILANAVR 

HTP

Length:253

Mass (Da):28,711

Last modified:March 15, 2005 - v1

Checksum:ⁱ0B32F6191BF2B779

GO

Isoform Short (identifier: P0A4T9-2) [UniParc]FASTA Add to basket

Also known as: TipA-S

The sequence of this isoform differs from the canonical sequence as follows:
1-109: Missing.

« Hide

        10         20         30         40         50
MGINLTPEEK FEVFGDFDPD QYEEEVRERW GNTDAYRQSK EKTASYTKED 
        60         70         80         90        100
WQRIQDEADE LTRRFVALMD AGEPADSEGA MDAAEDHRQG IARNHYDCGY 
       110        120        130        140 
EMHTCLGEMY VSDERFTRNI DAAKPGLAAY MRDAILANAV RHTP

Show »

Length:144

Mass (Da):16,563

Checksum:ⁱ11092740A7B10FDA

GO

Sequence cautionⁱ

The sequence AAC13653 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Alternative sequenceⁱ	1 – 109	109	Missing in isoform Short. Curated		VSP_018752	Add BLAST

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S64314 Genomic DNA. Translation: AAB27737.1. M24524 Genomic DNA. Translation: AAC13653.1. Different initiation.
PIRⁱ	S35354.

Keywords - Coding sequence diversityⁱ

Alternative initiation

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S64314 Genomic DNA. Translation: AAB27737.1. M24524 Genomic DNA. Translation: AAC13653.1. Different initiation.
PIRⁱ	S35354.

3D structure databases

Select the link destinations:
PDBeⁱ
RCSB PDBⁱ
PDBjⁱ

Links Updated

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1NY9	NMR	-	A	111-253	[»]
2MBZ	NMR	-	A	110-253	[»]
2MC0	NMR	-	A	110-253	[»]
2VZ4	X-ray	2.90	A	2-109	[»]

ProteinModelPortalⁱ

P0A4T9.

SMRⁱ

P0A4T9. Positions 160-253.

ModBaseⁱ

Search...

MobiDBⁱ

Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P0A4T9.

EvolutionaryTraceⁱ

P0A4T9.

Family and domain databases

Gene3Dⁱ	1.10.490.50. 1 hit.
InterProⁱ	IPR009061. DNA-bd_dom_put. IPR000551. MerR-type_HTH_dom. IPR012925. TipAS_dom. [Graphical view]
Pfamⁱ	PF13411. MerR_1. 1 hit. PF07739. TipAS. 1 hit. [Graphical view]
PRINTSⁱ	PR00040. HTHMERR.
SMARTⁱ	SM00422. HTH_MERR. 1 hit. [Graphical view]
SUPFAMⁱ	SSF46955. SSF46955. 1 hit. SSF89082. SSF89082. 1 hit.
PROSITEⁱ	PS00552. HTH_MERR_1. 1 hit. PS50937. HTH_MERR_2. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

TIPA_STRLI

Accessionⁱ

Primary (citable) accession number: P0A4T9
Secondary accession number(s): P32184

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	October 14, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0A4T9 (TIPA_STRLI)

UniProt

P0A4T9 - TIPA_STRLI

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HTH-type transcriptional activator TipA

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>Reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.</p><p><a href='../manual/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Miscellaneous databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ