UniProtKB - P0A4T9 (TIPA_STRLI)
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Protein
HTH-type transcriptional activator TipA
Gene
tipA
Organism
Streptomyces lividans
Status
Functioni
Transcriptional activator. Is activated when bound to the antibiotic thiostrepton.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 5 – 24 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- regulation of transcription, DNA-templated Source: UniProtKB-KW
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: HTH-type transcriptional activator TipA |
Gene namesi | Name:tipA |
Organismi | Streptomyces lividans |
Taxonomic identifieri | 1916 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptomycetales › Streptomycetaceae › Streptomyces |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000013606 | 1 – 253 | HTH-type transcriptional activator TipAAdd BLAST | 253 |
Interactioni
Subunit structurei
Homodimer.Curated
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 5 – 12 | Combined sources | 8 | |
Helixi | 16 – 24 | Combined sources | 9 | |
Beta strandi | 31 – 33 | Combined sources | 3 | |
Beta strandi | 39 – 41 | Combined sources | 3 | |
Helixi | 43 – 57 | Combined sources | 15 | |
Helixi | 62 – 69 | Combined sources | 8 | |
Helixi | 79 – 105 | Combined sources | 27 | |
Helixi | 116 – 123 | Combined sources | 8 | |
Helixi | 129 – 131 | Combined sources | 3 | |
Helixi | 132 – 138 | Combined sources | 7 | |
Helixi | 144 – 152 | Combined sources | 9 | |
Helixi | 165 – 180 | Combined sources | 16 | |
Helixi | 187 – 203 | Combined sources | 17 | |
Helixi | 209 – 218 | Combined sources | 10 | |
Helixi | 223 – 229 | Combined sources | 7 | |
Helixi | 230 – 232 | Combined sources | 3 | |
Beta strandi | 233 – 235 | Combined sources | 3 | |
Helixi | 236 – 251 | Combined sources | 16 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1NY9 | NMR | - | A | 111-253 | [»] | |
2MBZ | NMR | - | A | 110-253 | [»] | |
2MC0 | NMR | - | A | 110-253 | [»] | |
2VZ4 | X-ray | 2.90 | A | 2-109 | [»] | |
DisProti | DP00997 | |||||
ProteinModelPortali | P0A4T9 | |||||
SMRi | P0A4T9 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P0A4T9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 71 | HTH merR-typePROSITE-ProRule annotationAdd BLAST | 71 |
Family and domain databases
Gene3Di | 1.10.490.501 hit |
InterProi | View protein in InterPro IPR009061 DNA-bd_dom_put_sf IPR000551 MerR-type_HTH_dom IPR036244 TipA-like_antibiotic-bd IPR012925 TipAS_dom |
Pfami | View protein in Pfam PF13411 MerR_1, 1 hit PF07739 TipAS, 1 hit |
PRINTSi | PR00040 HTHMERR |
SMARTi | View protein in SMART SM00422 HTH_MERR, 1 hit |
SUPFAMi | SSF46955 SSF46955, 1 hit SSF89082 SSF89082, 1 hit |
PROSITEi | View protein in PROSITE PS00552 HTH_MERR_1, 1 hit PS50937 HTH_MERR_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basket
Isoform Long (identifier: P0A4T9-1) [UniParc]FASTAAdd to basket
Also known as: TipA-L
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MSYSVGQVAG FAGVTVRTLH HYDDIGLLVP SERSHAGHRR YSDADLDRLQ
60 70 80 90 100
QILFYRELGF PLDEVAALLD DPAADPRAHL RRQHELLSAR IGKLQKMAAA
110 120 130 140 150
VEQAMEARSM GINLTPEEKF EVFGDFDPDQ YEEEVRERWG NTDAYRQSKE
160 170 180 190 200
KTASYTKEDW QRIQDEADEL TRRFVALMDA GEPADSEGAM DAAEDHRQGI
210 220 230 240 250
ARNHYDCGYE MHTCLGEMYV SDERFTRNID AAKPGLAAYM RDAILANAVR
HTP
Isoform Short (identifier: P0A4T9-2) [UniParc]FASTAAdd to basket
Also known as: TipA-S
The sequence of this isoform differs from the canonical sequence as follows:
1-109: Missing.
Sequence cautioni
The sequence AAC13653 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018752 | 1 – 109 | Missing in isoform Short. CuratedAdd BLAST | 109 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S64314 Genomic DNA Translation: AAB27737.1 M24524 Genomic DNA Translation: AAC13653.1 Different initiation. |
PIRi | S35354 |
Keywords - Coding sequence diversityi
Alternative initiationSimilar proteinsi
Entry informationi
Entry namei | TIPA_STRLI | |
Accessioni | P0A4T9Primary (citable) accession number: P0A4T9 Secondary accession number(s): P32184 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | March 15, 2005 | |
Last modified: | March 28, 2018 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |