Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HTH-type transcriptional activator TipA

Gene

tipA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transcriptional activator. Is activated when bound to the antibiotic thiostrepton (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 24H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator TipA
Gene namesi
Name:tipA
Ordered Locus Names:SCO3413
ORF Names:SCE9.20
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981571 – 253HTH-type transcriptional activator TipAAdd BLAST253

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi100226.SCO3413.

Structurei

3D structure databases

ProteinModelPortaliP0A4T8.
SMRiP0A4T8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 71HTH merR-typePROSITE-ProRule annotationAdd BLAST71

Phylogenomic databases

eggNOGiENOG4107TXC. Bacteria.
COG0789. LUCA.
HOGENOMiHOG000240261.
InParanoidiP0A4T8.
OMAiMYVSDER.
OrthoDBiPOG091H07O6.
PhylomeDBiP0A4T8.

Family and domain databases

InterProiView protein in InterPro
IPR009061. DNA-bd_dom_put.
IPR000551. MerR-type_HTH_dom.
IPR012925. TipAS_dom.
PfamiView protein in Pfam
PF13411. MerR_1. 1 hit.
PF07739. TipAS. 1 hit.
PRINTSiPR00040. HTHMERR.
SMARTiView protein in SMART
SM00422. HTH_MERR. 1 hit.
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF89082. SSF89082. 1 hit.
PROSITEiView protein in PROSITE
PS00552. HTH_MERR_1. 1 hit.
PS50937. HTH_MERR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A4T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSVGQVAG FAGVTVRTLH HYDDIGLLVP SERSHAGHRR YSDADLDRLQ
60 70 80 90 100
QILFYRELGF PLDEVAALLD DPAADPRAHL RRQHELLSAR IGKLQKMAAA
110 120 130 140 150
VEQAMEARSM GINLTPEEKF EVFGDFDPDQ YEEEVRERWG NTDAYRQSKE
160 170 180 190 200
KTASYTKEDW QRIQDEADEL TRRFVALMDA GEPADSEGAM DAAEDHRQGI
210 220 230 240 250
ARNHYDCGYE MHTCLGEMYV SDERFTRNID AAKPGLAAYM RDAILANAVR

HTP
Length:253
Mass (Da):28,711
Last modified:March 15, 2005 - v1
Checksum:i0B32F6191BF2B779
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939116 Genomic DNA. Translation: CAB42766.1.
PIRiT36339.
RefSeqiNP_627619.1. NC_003888.3.
WP_003975420.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB42766; CAB42766; CAB42766.
GeneIDi1098850.
29661245.
KEGGisco:SCO3413.
PATRICifig|100226.15.peg.3476.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTIPA_STRCO
AccessioniPrimary (citable) accession number: P0A4T8
Secondary accession number(s): P32184
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 7, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome