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Protein

HTH-type transcriptional activator TipA

Gene

tipA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transcriptional activator. Is activated when bound to the antibiotic thiostrepton (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 24H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator TipA
Gene namesi
Name:tipA
Ordered Locus Names:SCO3413
ORF Names:SCE9.20
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981571 – 253HTH-type transcriptional activator TipAAdd BLAST253

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi100226.SCO3413.

Structurei

3D structure databases

ProteinModelPortaliP0A4T8.
SMRiP0A4T8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 71HTH merR-typePROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Contains 1 HTH merR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4107TXC. Bacteria.
COG0789. LUCA.
HOGENOMiHOG000240261.
InParanoidiP0A4T8.
OMAiFNTIYRN.
OrthoDBiPOG091H07O6.
PhylomeDBiP0A4T8.

Family and domain databases

Gene3Di1.10.490.50. 1 hit.
InterProiIPR009061. DNA-bd_dom_put.
IPR000551. MerR-type_HTH_dom.
IPR012925. TipAS_dom.
[Graphical view]
PfamiPF13411. MerR_1. 1 hit.
PF07739. TipAS. 1 hit.
[Graphical view]
PRINTSiPR00040. HTHMERR.
SMARTiSM00422. HTH_MERR. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF89082. SSF89082. 1 hit.
PROSITEiPS00552. HTH_MERR_1. 1 hit.
PS50937. HTH_MERR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A4T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSVGQVAG FAGVTVRTLH HYDDIGLLVP SERSHAGHRR YSDADLDRLQ
60 70 80 90 100
QILFYRELGF PLDEVAALLD DPAADPRAHL RRQHELLSAR IGKLQKMAAA
110 120 130 140 150
VEQAMEARSM GINLTPEEKF EVFGDFDPDQ YEEEVRERWG NTDAYRQSKE
160 170 180 190 200
KTASYTKEDW QRIQDEADEL TRRFVALMDA GEPADSEGAM DAAEDHRQGI
210 220 230 240 250
ARNHYDCGYE MHTCLGEMYV SDERFTRNID AAKPGLAAYM RDAILANAVR

HTP
Length:253
Mass (Da):28,711
Last modified:March 15, 2005 - v1
Checksum:i0B32F6191BF2B779
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939116 Genomic DNA. Translation: CAB42766.1.
PIRiT36339.
RefSeqiNP_627619.1. NC_003888.3.
WP_003975420.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB42766; CAB42766; CAB42766.
GeneIDi1098850.
KEGGisco:SCO3413.
PATRICi23736582. VBIStrCoe124346_3476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939116 Genomic DNA. Translation: CAB42766.1.
PIRiT36339.
RefSeqiNP_627619.1. NC_003888.3.
WP_003975420.1. NC_003888.3.

3D structure databases

ProteinModelPortaliP0A4T8.
SMRiP0A4T8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO3413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB42766; CAB42766; CAB42766.
GeneIDi1098850.
KEGGisco:SCO3413.
PATRICi23736582. VBIStrCoe124346_3476.

Phylogenomic databases

eggNOGiENOG4107TXC. Bacteria.
COG0789. LUCA.
HOGENOMiHOG000240261.
InParanoidiP0A4T8.
OMAiFNTIYRN.
OrthoDBiPOG091H07O6.
PhylomeDBiP0A4T8.

Family and domain databases

Gene3Di1.10.490.50. 1 hit.
InterProiIPR009061. DNA-bd_dom_put.
IPR000551. MerR-type_HTH_dom.
IPR012925. TipAS_dom.
[Graphical view]
PfamiPF13411. MerR_1. 1 hit.
PF07739. TipAS. 1 hit.
[Graphical view]
PRINTSiPR00040. HTHMERR.
SMARTiSM00422. HTH_MERR. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF89082. SSF89082. 1 hit.
PROSITEiPS00552. HTH_MERR_1. 1 hit.
PS50937. HTH_MERR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTIPA_STRCO
AccessioniPrimary (citable) accession number: P0A4T8
Secondary accession number(s): P32184
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.