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Protein

HTH-type transcriptional activator TipA

Gene

tipA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transcriptional activator. Is activated when bound to the antibiotic thiostrepton (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 24H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional activator TipA
Gene namesi
Name:tipA
Ordered Locus Names:SCO3413
ORF Names:SCE9.20
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981571 – 253HTH-type transcriptional activator TipAAdd BLAST253

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi100226.SCO3413

Structurei

3D structure databases

ProteinModelPortaliP0A4T8
SMRiP0A4T8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 71HTH merR-typePROSITE-ProRule annotationAdd BLAST71

Phylogenomic databases

eggNOGiENOG4107TXC Bacteria
COG0789 LUCA
HOGENOMiHOG000240261
InParanoidiP0A4T8
KOiK21744
OMAiMYVSDER
OrthoDBiPOG091H07O6
PhylomeDBiP0A4T8

Family and domain databases

Gene3Di1.10.490.50, 1 hit
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR000551 MerR-type_HTH_dom
IPR036244 TipA-like_antibiotic-bd
IPR012925 TipAS_dom
PfamiView protein in Pfam
PF13411 MerR_1, 1 hit
PF07739 TipAS, 1 hit
PRINTSiPR00040 HTHMERR
SMARTiView protein in SMART
SM00422 HTH_MERR, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF89082 SSF89082, 1 hit
PROSITEiView protein in PROSITE
PS00552 HTH_MERR_1, 1 hit
PS50937 HTH_MERR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P0A4T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSYSVGQVAG FAGVTVRTLH HYDDIGLLVP SERSHAGHRR YSDADLDRLQ
60 70 80 90 100
QILFYRELGF PLDEVAALLD DPAADPRAHL RRQHELLSAR IGKLQKMAAA
110 120 130 140 150
VEQAMEARSM GINLTPEEKF EVFGDFDPDQ YEEEVRERWG NTDAYRQSKE
160 170 180 190 200
KTASYTKEDW QRIQDEADEL TRRFVALMDA GEPADSEGAM DAAEDHRQGI
210 220 230 240 250
ARNHYDCGYE MHTCLGEMYV SDERFTRNID AAKPGLAAYM RDAILANAVR

HTP
Length:253
Mass (Da):28,711
Last modified:March 15, 2005 - v1
Checksum:i0B32F6191BF2B779
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939116 Genomic DNA Translation: CAB42766.1
PIRiT36339
RefSeqiNP_627619.1, NC_003888.3
WP_003975420.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB42766; CAB42766; CAB42766
GeneIDi1098850
29661245
KEGGisco:SCO3413
PATRICifig|100226.15.peg.3476

Similar proteinsi

Entry informationi

Entry nameiTIPA_STRCO
AccessioniPrimary (citable) accession number: P0A4T8
Secondary accession number(s): P32184
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health