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P0A4S7

- LFTR_BRUME

UniProt

P0A4S7 - LFTR_BRUME

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Protein
Leucyl/phenylalanyl-tRNA--protein transferase
Gene
aat, BMEI1064
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine By similarity.UniRule annotation

Catalytic activityi

L-leucyl-tRNA(Leu) + [protein] = tRNA(Leu) + L-leucyl-[protein].UniRule annotation
L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein].UniRule annotation

GO - Molecular functioni

  1. leucyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Leucyl/phenylalanyl-tRNA--protein transferase (EC:2.3.2.6)
Alternative name(s):
L/F-transferase
Leucyltransferase
Phenyalanyltransferase
Gene namesi
Name:aat
Ordered Locus Names:BMEI1064
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204Leucyl/phenylalanyl-tRNA--protein transferaseUniRule annotation
PRO_0000207208Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224914.BMEI1064.

Structurei

3D structure databases

ProteinModelPortaliP0A4S7.

Family & Domainsi

Sequence similaritiesi

Belongs to the L/F-transferase family.

Phylogenomic databases

HOGENOMiHOG000102326.
KOiK00684.
OMAiIGHAHSV.
OrthoDBiEOG6WX4R3.

Family and domain databases

HAMAPiMF_00688. Leu_Phe_trans.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view]
PfamiPF03588. Leu_Phe_trans. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR00667. aat. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A4S7-1 [UniParc]FASTAAdd to Basket

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MTAEAPPDDD IIEPEMLLRA YATGIFPMAE EADDPEVFWV RPEKRGVIPL    50
DGFHIPRSLQ KTIRQGIFEI RLDSNFAGVI EGCASGTGER ARTWINEPIR 100
RAYAKLFEIG HCHTVEAWYE GKLAGGLYGV TLGRAFFGES MFTRKRDASK 150
VCLAYLVQHL SRQGFVLLDT QFTTPHLERF GALEVPRKEY EEMLERALEG 200
IARF 204
Length:204
Mass (Da):23,153
Last modified:March 15, 2005 - v1
Checksum:i2B2155002265E0EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52245.1.
PIRiAB3385.
RefSeqiNP_539981.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52245; AAL52245; BMEI1064.
GeneIDi1196775.
KEGGibme:BMEI1064.
PATRICi17797912. VBIBruMel146950_0771.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52245.1 .
PIRi AB3385.
RefSeqi NP_539981.1. NC_003317.1.

3D structure databases

ProteinModelPortali P0A4S7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI1064.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL52245 ; AAL52245 ; BMEI1064 .
GeneIDi 1196775.
KEGGi bme:BMEI1064.
PATRICi 17797912. VBIBruMel146950_0771.

Phylogenomic databases

HOGENOMi HOG000102326.
KOi K00684.
OMAi IGHAHSV.
OrthoDBi EOG6WX4R3.

Family and domain databases

HAMAPi MF_00688. Leu_Phe_trans.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view ]
Pfami PF03588. Leu_Phe_trans. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
TIGRFAMsi TIGR00667. aat. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiLFTR_BRUME
AccessioniPrimary (citable) accession number: P0A4S7
Secondary accession number(s): Q8G123, Q8YGU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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