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Reviewed, UniProtKB/Swiss-Prot P0A4L6 (DSBA_ECO27)

Last modified July 7, 2009. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Thiol:disulfide interchange protein dsbA
Gene names
Name: dsbA
Ordered Locus Names: E2348_C_4167
OrganismEscherichia coli O127:H6 (strain E2348/69 / EPEC) [Complete proteome] [HAMAP]
Taxonomic identifier574521 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Required for disulfide bond formation in some periplasmic proteins such as phoA or ompA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by dsbB. It is required for pilus biogenesis By similarity.

Subcellular location

Periplasm By similarity.

Sequence similarities

Belongs to the thioredoxin family. DsbA subfamily.

Contains 1 thioredoxin domain.

Ontologies

Keywords
   Cellular componentPeriplasm
   DomainRedox-active center
Signal
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

   Cellular componentouter membrane-bounded periplasmic space

Inferred from electronic annotation. Source: InterPro

   Molecular functionprotein disulfide oxidoreductase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity
Chain20 – 208189Thiol:disulfide interchange protein dsbA
PRO_0000034253

Regions

Domain20 – 150131Thioredoxin

Amino acid modifications

Disulfide bond49 ↔ 52Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A4L6-1 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 01527E876ECAEE92

FASTA20823,119
        10         20         30         40         50         60 
MKKIWLALAG LVLAFSASAA QYEDGKQYTT LEKPVAGAPQ VLEFFSFFCP HCYQFEEVLH 

        70         80         90        100        110        120 
ISDNVKKKLP EGVKMTKYHV NFMGGDLGKE LTQAWAVAMA LGVEDKVTVP LFEGVQKTQT 

       130        140        150        160        170        180 
IRSASDIRDV FINAGIKGEE YDAAWNSFVV KSLVAQQEKA AADVQLRGVP AMFVNGKYQL 

       190        200 
NPQGMDTSNM DVFVQQYADT VKYLSEKK 

« Hide

References

« Hide 'large scale' references
[1]"DsbA is required for stability of the type IV pilin of enteropathogenic Escherichia coli."
Zhang H.Z., Donnenberg M.S.
Mol. Microbiol. 21:787-797(1996) [PubMed: 8878041] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69."
Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G.
J. Bacteriol. 191:347-354(2009) [PubMed: 18952797] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

Z54203 Genomic DNA. Translation: CAA90910.1.
FM180568 Genomic DNA. Translation: CAS11715.1.
RefSeqYP_002331625.1.

3D structure databases

HSSPHSSP built from PDB template 1A23 based on UniProtKB P24991.
SMRP0A4L6. Positions 20-207.
ModBaseSearch...

Genome annotation databases

GeneID7063974.
GenomeReviewsGene locus E2348_C_4167 in contig FM180568_GR.
KEGGecg:E2348C_4167.

Organism-specific databases

CMRSearch...

Family and domain databases

InterProIPR001853. OxRdtase_DSBA.
IPR017936. Thioredoxin-like.
IPR017937. Thioredoxin_CS.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PfamPF01323. DSBA. 1 hit.
[Graphical view]
PROSITEPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDSBA_ECO27
AccessionPrimary (citable) accession number: P0A4L6
Secondary accession number(s): B7UNI3, P59589
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: July 7, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents