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Protein

Multi-drug resistance efflux pump PmrA

Gene

pmrA

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Efflux pump for various substrates.

GO - Molecular functioni

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.1.2.34. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Multi-drug resistance efflux pump PmrA
Gene namesi
Name:pmrA
Ordered Locus Names:SP_0972
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 34HelicalSequence analysisAdd BLAST23
Transmembranei49 – 71HelicalSequence analysisAdd BLAST23
Transmembranei84 – 106HelicalSequence analysisAdd BLAST23
Transmembranei140 – 162HelicalSequence analysisAdd BLAST23
Transmembranei167 – 186HelicalSequence analysisAdd BLAST20
Transmembranei217 – 239HelicalSequence analysisAdd BLAST23
Transmembranei248 – 270HelicalSequence analysisAdd BLAST23
Transmembranei306 – 328HelicalSequence analysisAdd BLAST23
Transmembranei340 – 362HelicalSequence analysisAdd BLAST23
Transmembranei366 – 388HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001733771 – 399Multi-drug resistance efflux pump PmrAAdd BLAST399

Structurei

3D structure databases

ProteinModelPortaliP0A4K4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C6X. Bacteria.
ENOG410ZVCH. LUCA.
HOGENOMiHOG000066093.
OMAiRIGYQIP.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR001958. Tet-R_TetA/multi-R_MdtG.
PfamiView protein in Pfam
PF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A4K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEINWKDNL RIAWFGNFLT GASISLVVPF MPIFVENLGV GSQQVAFYAG
60 70 80 90 100
LAISVSAISA ALFSPIWGIL ADKYGRKPMM IRAGLAMTIT MGGLAFVPNI
110 120 130 140 150
YWLIFLRLLN GVFAGFVPNA TALIASQVPK EKSGSALGTL STGVVAGTLT
160 170 180 190 200
GPFIGGFIAE LFGIRTVFLL VGSFLFLAAI LTICFIKEDF QPVAKEKAIP
210 220 230 240 250
TKELFTSVKY PYLLLNLFLT SFVIQFSAQS IGPILALYVR DLGQTENLLF
260 270 280 290 300
VSGLIVSSMG FSSMMSAGVM GKLGDKVGNH RLLVVAQFYS VIIYLLCANA
310 320 330 340 350
SSPLQLGLYR FLFGLGTGAL IPGVNALLSK MTPKAGISRV FAFNQVFFYL
360 370 380 390
GGVVGPMAGS AVAGQFGYHA VFYATSLCVA FSCLFNLIQF RTLLKVKEI
Length:399
Mass (Da):42,840
Last modified:March 15, 2005 - v1
Checksum:i58F97634E006AD8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007367 Genomic DNA. Translation: CAA07482.1.
AE005672 Genomic DNA. Translation: AAK75093.1.
PIRiD95112.
RefSeqiWP_000136147.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK75093; AAK75093; SP_0972.
KEGGispn:SP_0972.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPMRA_STRPN
AccessioniPrimary (citable) accession number: P0A4K4
Secondary accession number(s): Q9ZEX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: July 5, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families