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Protein

Multi-drug resistance efflux pump PmrA

Gene

pmrA

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Efflux pump for various substrates.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-976-MONOMER.

Protein family/group databases

TCDBi2.A.1.2.34. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Multi-drug resistance efflux pump PmrA
Gene namesi
Name:pmrA
Ordered Locus Names:SP_0972
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3423HelicalSequence analysisAdd
BLAST
Transmembranei49 – 7123HelicalSequence analysisAdd
BLAST
Transmembranei84 – 10623HelicalSequence analysisAdd
BLAST
Transmembranei140 – 16223HelicalSequence analysisAdd
BLAST
Transmembranei167 – 18620HelicalSequence analysisAdd
BLAST
Transmembranei217 – 23923HelicalSequence analysisAdd
BLAST
Transmembranei248 – 27023HelicalSequence analysisAdd
BLAST
Transmembranei306 – 32823HelicalSequence analysisAdd
BLAST
Transmembranei340 – 36223HelicalSequence analysisAdd
BLAST
Transmembranei366 – 38823HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399Multi-drug resistance efflux pump PmrAPRO_0000173377Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi170187.SpneT_02000855.

Structurei

3D structure databases

ProteinModelPortaliP0A4K4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C6X. Bacteria.
ENOG410ZVCH. LUCA.
HOGENOMiHOG000066093.
OMAiFTQSNAD.
OrthoDBiEOG6VF34T.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A4K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEINWKDNL RIAWFGNFLT GASISLVVPF MPIFVENLGV GSQQVAFYAG
60 70 80 90 100
LAISVSAISA ALFSPIWGIL ADKYGRKPMM IRAGLAMTIT MGGLAFVPNI
110 120 130 140 150
YWLIFLRLLN GVFAGFVPNA TALIASQVPK EKSGSALGTL STGVVAGTLT
160 170 180 190 200
GPFIGGFIAE LFGIRTVFLL VGSFLFLAAI LTICFIKEDF QPVAKEKAIP
210 220 230 240 250
TKELFTSVKY PYLLLNLFLT SFVIQFSAQS IGPILALYVR DLGQTENLLF
260 270 280 290 300
VSGLIVSSMG FSSMMSAGVM GKLGDKVGNH RLLVVAQFYS VIIYLLCANA
310 320 330 340 350
SSPLQLGLYR FLFGLGTGAL IPGVNALLSK MTPKAGISRV FAFNQVFFYL
360 370 380 390
GGVVGPMAGS AVAGQFGYHA VFYATSLCVA FSCLFNLIQF RTLLKVKEI
Length:399
Mass (Da):42,840
Last modified:March 15, 2005 - v1
Checksum:i58F97634E006AD8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007367 Genomic DNA. Translation: CAA07482.1.
AE005672 Genomic DNA. Translation: AAK75093.1.
PIRiD95112.
RefSeqiWP_000136147.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK75093; AAK75093; SP_0972.
KEGGispn:SP_0972.
PATRICi19706349. VBIStrPne105772_1019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007367 Genomic DNA. Translation: CAA07482.1.
AE005672 Genomic DNA. Translation: AAK75093.1.
PIRiD95112.
RefSeqiWP_000136147.1. NZ_AKVY01000001.1.

3D structure databases

ProteinModelPortaliP0A4K4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SpneT_02000855.

Protein family/group databases

TCDBi2.A.1.2.34. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK75093; AAK75093; SP_0972.
KEGGispn:SP_0972.
PATRICi19706349. VBIStrPne105772_1019.

Phylogenomic databases

eggNOGiENOG4105C6X. Bacteria.
ENOG410ZVCH. LUCA.
HOGENOMiHOG000066093.
OMAiFTQSNAD.
OrthoDBiEOG6VF34T.

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-976-MONOMER.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
PF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae."
    Gill M.J., Brenwald N.P., Wise R.
    Antimicrob. Agents Chemother. 43:187-189(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.

Entry informationi

Entry nameiPMRA_STRPN
AccessioniPrimary (citable) accession number: P0A4K4
Secondary accession number(s): Q9ZEX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 11, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.