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Reviewed, UniProtKB/Swiss-Prot P0A4I7 (CUTS_STRCO)

Last modified February 9, 2010. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Sensor protein cutS
    EC=2.7.13.3
Gene names
Name: cutS
Ordered Locus Names: SCO5863
ORF Names: SC2E9.04
OrganismStreptomyces coelicolor [Complete proteome] [HAMAP]
Taxonomic identifier1902 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Member of the two-component regulatory system cutS/cutR, involved in the regulation of copper metabolism.

Catalytic activity

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Contains 1 HAMP domain.

Contains 1 histidine kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 414414Sensor protein cutS
PRO_0000074744

Regions

Transmembrane37 – 5721 Potential
Transmembrane121 – 14121 Potential
Domain142 – 19453HAMP
Domain202 – 414213Histidine kinase

Amino acid modifications

Modified residue2051Phosphohistidine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A4I7-1 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: B1CBC2DFBD0ABB4D

FASTA41444,496
        10         20         30         40         50         60 
MATTPAPPGA PPKPTWDPRS ATPLPWLRPT IRIRLTLLYG GMFLIAGILL LSIIYLLAAQ 

        70         80         90        100        110        120 
AVRTGNEPLY KIVDFTDLKV SSSTCPVVDN GGLSLSDFNA AISDCMDHQR KVALDNLLSR 

       130        140        150        160        170        180 
SLLALLGLAV IAFAFGYAMA GRVLSPLGRI TRTARAVAGS DLSRRIELDG PDDELKELAD 

       190        200        210        220        230        240 
TFDDMLERLQ RAFTAQQRFV GNASHELRTP LAINRTLLEV HLSDPGAPVE LQQLGKTLLA 

       250        260        270        280        290        300 
TNERSELLVE GLLLLARSDN QIVERKPVDL AEVAGQAIDQ VHAEAESKGV EVRGTREAAV 

       310        320        330        340        350        360 
VQGNGVLLER IALNLVQNAV RYNVAGQGWV EVATAVENGQ AVLVVTNTGP VVPAYEVDNL 

       370        380        390        400        410 
FEPFRRLRTE RTGSDKGVGL GLSIARSVAR AHGGHISAQP REGGGLVMRV TLPV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939125 Genomic DNA. Translation: CAA16472.1.
PIRT34815.
RefSeqNP_629985.1.

3D structure databases

SMRP0A4I7. Positions 178-413.
ModBaseSearch...

Genome annotation databases

GeneID1101305.
KEGGsco:SCO5863.
NMPDRfig|100226.1.peg.5812.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG334875.
OMALARRTEC.

Enzyme and pathway databases

BioCycSCOE100226:SCO5863-MONOMER.
BRENDA2.7.13.3. 1084.

Family and domain databases

InterProIPR003594. ATPase-like_ATP-bd.
IPR003660. HAMP_linker_domain.
IPR004358. Sig_transdc_His_kin-like_C.
IPR003661. Sig_transdc_His_kin_sub1_dim/P.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view]
Gene3DG3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit.
PfamPF00672. HAMP. 1 hit.
PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSPR00344. BCTRLSENSOR.
SMARTSM00304. HAMP. 1 hit.
SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
PROSITEPS50885. HAMP. 1 hit.
PS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCUTS_STRCO
AccessionPrimary (citable) accession number: P0A4I7
Secondary accession number(s): Q03757
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: February 9, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents