P0A4I7 (CUTS_STRCO) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 56.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Sensor protein CutS EC=2.7.13.3 | ||||||
| Gene names |
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| Organism | Streptomyces coelicolor | ||||||
| Taxonomic identifier | 1902 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces |
Protein attributes
| Sequence length | 414 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. |
| Catalytic activity | ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. |
| Subcellular location | Cell membrane; Multi-pass membrane protein Potential. |
| Sequence similarities | Contains 1 HAMP domain. Contains 1 histidine kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Two-component regulatory system |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane Transmembrane helix |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | peptidyl-histidine phosphorylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW two-component sensor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 414 | 414 | Sensor protein CutS | PRO_0000074744 | |||||
Regions | |||||||||
| Transmembrane | 37 – 57 | 21 | Helical; Potential | ||||||
| Transmembrane | 121 – 141 | 21 | Helical; Potential | ||||||
| Domain | 142 – 194 | 53 | HAMP | ||||||
| Domain | 202 – 414 | 213 | Histidine kinase | ||||||
Amino acid modifications | |||||||||
| Modified residue | 205 | 1 | Phosphohistidine; by autocatalysis By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. Hopwood D.A.Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL939125 Genomic DNA. Translation: CAA16472.1. |
| PIR | T34815. |
| RefSeq | NP_629985.1. NC_003888.3. |
3D structure databases | |
| ProteinModelPortal | P0A4I7. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1101305. |
| GenomeReviews | Gene locus SCO5863 in contig AL645882_GR. |
| KEGG | sco:SCO5863. |
| NMPDR | fig|100226.1.peg.5812. |
| PATRIC | 23741630. VBIStrCoe124346_5962. |
Phylogenomic databases | |
| HOGENOM | HBG334875. |
| OMA | PTIRIRL. |
| PhylomeDB | P0A4I7. |
| ProtClustDB | CLSK902991. |
Family and domain databases | |
| InterPro | IPR003594. ATPase-like_ATP-bd. IPR003660. HAMP_linker_domain. IPR004358. Sig_transdc_His_kin-like_C. IPR003661. Sig_transdc_His_kin_sub1_dim/P. IPR005467. Sig_transdc_His_kinase_core. IPR009082. Sig_transdc_His_kinase_dimeric. [Graphical view] |
| Gene3D | G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. |
| KO | K00936. |
| Pfam | PF00672. HAMP. 1 hit. PF02518. HATPase_c. 1 hit. PF00512. HisKA. 1 hit. [Graphical view] |
| PRINTS | PR00344. BCTRLSENSOR. |
| SMART | SM00304. HAMP. 1 hit. SM00387. HATPase_c. 1 hit. SM00388. HisKA. 1 hit. [Graphical view] |
| SUPFAM | SSF55874. ATP_bd_ATPase. 1 hit. SSF47384. His_kin_homodim. 1 hit. |
| PROSITE | PS50885. HAMP. 1 hit. PS50109. HIS_KIN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CUTS_STRCO | ||||||||
| Accession | Primary (citable) accession number: P0A4I7 Secondary accession number(s): Q03757 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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