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P0A4I6 (CIAH_STRR6) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sensor protein CiaH

EC=2.7.13.3
Gene names
Name:ciaH
Ordered Locus Names:spr0708
OrganismStreptococcus pneumoniae (strain ATCC BAA-255 / R6) [Reference proteome] [HAMAP]
Taxonomic identifier171101 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR.

Catalytic activity

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Contains 1 histidine kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 444444Sensor protein CiaH
PRO_0000074723

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane183 – 20321Helical; Potential
Domain223 – 438216Histidine kinase

Amino acid modifications

Modified residue2261Phosphohistidine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A4I6 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 1D36CAE8D21D3337

FASTA44450,673
        10         20         30         40         50         60 
MFSKLKKTWY ADDFSYFIRN FGVFTLIFST MTLIILQVMH SSLYTSVDDK LHGLSENPQA 

        70         80         90        100        110        120 
VIQLAINRAT EEIKDLENAR ADASKVEIKP NVSSNTEVIL FDKDFTQLLS GNRFLGLDKI 

       130        140        150        160        170        180 
KLEKKELGHI YQIQVFNSYG QEEIYRVILM ETNISSVSTN IKYAAVLINT SQLEQASQKH 

       190        200        210        220        230        240 
EQLIVVVMAS FWILSLLASL YLARVSVRPL LESMQKQQSF VENASHELRT PLAVLQNRLE 

       250        260        270        280        290        300 
TLFRKPEATI MDVSESIASS LEEVRNMRFL TTSLLNLARR DDGIKPELAE VPTSFFNTTF 

       310        320        330        340        350        360 
TNYEMIASEN NRVFRFENRI HRTIVTDQLL LKQLMTILFD NAVKYTEEDG EIDFLISATD 

       370        380        390        400        410        420 
RNLYLLVSDN GIGISTEDKK KIFDRFYRVD KARTRQKGGF GLGLSLAKQI VDALKGTVTV 

       430        440 
KDNKPKGTIF EVKIAIQTPS KKKK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X77249 Genomic DNA. Translation: CAA54466.1.
AE007317 Genomic DNA. Translation: AAK99512.1.
PIRD97960.
S49545.
RefSeqNP_358302.1. NC_003098.1.

3D structure databases

ProteinModelPortalP0A4I6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING171101.spr0708.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK99512; AAK99512; spr0708.
GeneID934244.
KEGGspr:spr0708.
PATRIC19701324. VBIStrPne107296_0784.

Phylogenomic databases

eggNOGCOG0642.
HOGENOMHOG000223177.
KOK14982.
OMAMIVFWLI.
OrthoDBEOG6G4VQG.
ProtClustDBCLSK876906.

Enzyme and pathway databases

BioCycSPNE171101:GJC8-715-MONOMER.

Family and domain databases

Gene3D1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProIPR003661. EnvZ-like_dim/P.
IPR003594. HATPase_ATP-bd.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view]
PfamPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSPR00344. BCTRLSENSOR.
SMARTSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEPS50109. HIS_KIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCIAH_STRR6
AccessionPrimary (citable) accession number: P0A4I6
Secondary accession number(s): Q54955
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families