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P0A4I6

- CIAH_STRR6

UniProt

P0A4I6 - CIAH_STRR6

Protein

Sensor protein CiaH

Gene

ciaH

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR.

    Catalytic activityi

    ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphorelay sensor kinase activity Source: InterPro

    GO - Biological processi

    1. establishment of competence for transformation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Competence, Two-component regulatory system

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPNE171101:GJC8-715-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sensor protein CiaH (EC:2.7.13.3)
    Gene namesi
    Name:ciaH
    Ordered Locus Names:spr0708
    OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
    Taxonomic identifieri171101 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000586: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 444444Sensor protein CiaHPRO_0000074723Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei226 – 2261Phosphohistidine; by autocatalysisPROSITE-ProRule annotation

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi171101.spr0708.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A4I6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini223 – 438216Histidine kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 histidine kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0642.
    HOGENOMiHOG000223177.
    KOiK14982.
    OMAiMIVFWLI.
    OrthoDBiEOG6G4VQG.

    Family and domain databases

    Gene3Di1.10.287.130. 1 hit.
    3.30.565.10. 1 hit.
    InterProiIPR003661. EnvZ-like_dim/P.
    IPR003594. HATPase_ATP-bd.
    IPR004358. Sig_transdc_His_kin-like_C.
    IPR005467. Sig_transdc_His_kinase_core.
    IPR009082. Sig_transdc_His_kinase_dimeric.
    [Graphical view]
    PfamiPF02518. HATPase_c. 1 hit.
    PF00512. HisKA. 1 hit.
    [Graphical view]
    PRINTSiPR00344. BCTRLSENSOR.
    SMARTiSM00387. HATPase_c. 1 hit.
    SM00388. HisKA. 1 hit.
    [Graphical view]
    SUPFAMiSSF47384. SSF47384. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEiPS50109. HIS_KIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A4I6-1 [UniParc]FASTAAdd to Basket

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    MFSKLKKTWY ADDFSYFIRN FGVFTLIFST MTLIILQVMH SSLYTSVDDK    50
    LHGLSENPQA VIQLAINRAT EEIKDLENAR ADASKVEIKP NVSSNTEVIL 100
    FDKDFTQLLS GNRFLGLDKI KLEKKELGHI YQIQVFNSYG QEEIYRVILM 150
    ETNISSVSTN IKYAAVLINT SQLEQASQKH EQLIVVVMAS FWILSLLASL 200
    YLARVSVRPL LESMQKQQSF VENASHELRT PLAVLQNRLE TLFRKPEATI 250
    MDVSESIASS LEEVRNMRFL TTSLLNLARR DDGIKPELAE VPTSFFNTTF 300
    TNYEMIASEN NRVFRFENRI HRTIVTDQLL LKQLMTILFD NAVKYTEEDG 350
    EIDFLISATD RNLYLLVSDN GIGISTEDKK KIFDRFYRVD KARTRQKGGF 400
    GLGLSLAKQI VDALKGTVTV KDNKPKGTIF EVKIAIQTPS KKKK 444
    Length:444
    Mass (Da):50,673
    Last modified:March 15, 2005 - v1
    Checksum:i1D36CAE8D21D3337
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77249 Genomic DNA. Translation: CAA54466.1.
    AE007317 Genomic DNA. Translation: AAK99512.1.
    PIRiD97960.
    S49545.
    RefSeqiNP_358302.1. NC_003098.1.
    WP_000491790.1. NC_003098.1.

    Genome annotation databases

    EnsemblBacteriaiAAK99512; AAK99512; spr0708.
    GeneIDi934244.
    KEGGispr:spr0708.
    PATRICi19701324. VBIStrPne107296_0784.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77249 Genomic DNA. Translation: CAA54466.1 .
    AE007317 Genomic DNA. Translation: AAK99512.1 .
    PIRi D97960.
    S49545.
    RefSeqi NP_358302.1. NC_003098.1.
    WP_000491790.1. NC_003098.1.

    3D structure databases

    ProteinModelPortali P0A4I6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 171101.spr0708.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK99512 ; AAK99512 ; spr0708 .
    GeneIDi 934244.
    KEGGi spr:spr0708.
    PATRICi 19701324. VBIStrPne107296_0784.

    Phylogenomic databases

    eggNOGi COG0642.
    HOGENOMi HOG000223177.
    KOi K14982.
    OMAi MIVFWLI.
    OrthoDBi EOG6G4VQG.

    Enzyme and pathway databases

    BioCyci SPNE171101:GJC8-715-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.130. 1 hit.
    3.30.565.10. 1 hit.
    InterProi IPR003661. EnvZ-like_dim/P.
    IPR003594. HATPase_ATP-bd.
    IPR004358. Sig_transdc_His_kin-like_C.
    IPR005467. Sig_transdc_His_kinase_core.
    IPR009082. Sig_transdc_His_kinase_dimeric.
    [Graphical view ]
    Pfami PF02518. HATPase_c. 1 hit.
    PF00512. HisKA. 1 hit.
    [Graphical view ]
    PRINTSi PR00344. BCTRLSENSOR.
    SMARTi SM00387. HATPase_c. 1 hit.
    SM00388. HisKA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47384. SSF47384. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEi PS50109. HIS_KIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae."
      Guenzi E., Gasc A.M., Sicard M.A., Hakenbeck R.
      Mol. Microbiol. 12:505-515(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-255 / R6.

    Entry informationi

    Entry nameiCIAH_STRR6
    AccessioniPrimary (citable) accession number: P0A4I6
    Secondary accession number(s): Q54955
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3