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P0A4I6

- CIAH_STRR6

UniProt

P0A4I6 - CIAH_STRR6

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Protein
Sensor protein CiaH
Gene
ciaH, spr0708
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR.

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphorelay sensor kinase activity Source: InterPro

GO - Biological processi

  1. establishment of competence for transformation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Competence, Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-715-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein CiaH (EC:2.7.13.3)
Gene namesi
Name:ciaH
Ordered Locus Names:spr0708
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000586: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121Helical; Reviewed prediction
Add
BLAST
Transmembranei183 – 20321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Sensor protein CiaH
PRO_0000074723Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei226 – 2261Phosphohistidine; by autocatalysis By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi171101.spr0708.

Structurei

3D structure databases

ProteinModelPortaliP0A4I6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini223 – 438216Histidine kinase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0642.
HOGENOMiHOG000223177.
KOiK14982.
OMAiMIVFWLI.
OrthoDBiEOG6G4VQG.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003661. EnvZ-like_dim/P.
IPR003594. HATPase_ATP-bd.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A4I6-1 [UniParc]FASTAAdd to Basket

« Hide

MFSKLKKTWY ADDFSYFIRN FGVFTLIFST MTLIILQVMH SSLYTSVDDK    50
LHGLSENPQA VIQLAINRAT EEIKDLENAR ADASKVEIKP NVSSNTEVIL 100
FDKDFTQLLS GNRFLGLDKI KLEKKELGHI YQIQVFNSYG QEEIYRVILM 150
ETNISSVSTN IKYAAVLINT SQLEQASQKH EQLIVVVMAS FWILSLLASL 200
YLARVSVRPL LESMQKQQSF VENASHELRT PLAVLQNRLE TLFRKPEATI 250
MDVSESIASS LEEVRNMRFL TTSLLNLARR DDGIKPELAE VPTSFFNTTF 300
TNYEMIASEN NRVFRFENRI HRTIVTDQLL LKQLMTILFD NAVKYTEEDG 350
EIDFLISATD RNLYLLVSDN GIGISTEDKK KIFDRFYRVD KARTRQKGGF 400
GLGLSLAKQI VDALKGTVTV KDNKPKGTIF EVKIAIQTPS KKKK 444
Length:444
Mass (Da):50,673
Last modified:March 15, 2005 - v1
Checksum:i1D36CAE8D21D3337
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77249 Genomic DNA. Translation: CAA54466.1.
AE007317 Genomic DNA. Translation: AAK99512.1.
PIRiD97960.
S49545.
RefSeqiNP_358302.1. NC_003098.1.
WP_000491790.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAK99512; AAK99512; spr0708.
GeneIDi934244.
KEGGispr:spr0708.
PATRICi19701324. VBIStrPne107296_0784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77249 Genomic DNA. Translation: CAA54466.1 .
AE007317 Genomic DNA. Translation: AAK99512.1 .
PIRi D97960.
S49545.
RefSeqi NP_358302.1. NC_003098.1.
WP_000491790.1. NC_003098.1.

3D structure databases

ProteinModelPortali P0A4I6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 171101.spr0708.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK99512 ; AAK99512 ; spr0708 .
GeneIDi 934244.
KEGGi spr:spr0708.
PATRICi 19701324. VBIStrPne107296_0784.

Phylogenomic databases

eggNOGi COG0642.
HOGENOMi HOG000223177.
KOi K14982.
OMAi MIVFWLI.
OrthoDBi EOG6G4VQG.

Enzyme and pathway databases

BioCyci SPNE171101:GJC8-715-MONOMER.

Family and domain databases

Gene3Di 1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProi IPR003661. EnvZ-like_dim/P.
IPR003594. HATPase_ATP-bd.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view ]
Pfami PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view ]
PRINTSi PR00344. BCTRLSENSOR.
SMARTi SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view ]
SUPFAMi SSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEi PS50109. HIS_KIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae."
    Guenzi E., Gasc A.M., Sicard M.A., Hakenbeck R.
    Mol. Microbiol. 12:505-515(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-255 / R6.

Entry informationi

Entry nameiCIAH_STRR6
AccessioniPrimary (citable) accession number: P0A4I6
Secondary accession number(s): Q54955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi