Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P0A4I6

- CIAH_STRR6

UniProt

P0A4I6 - CIAH_STRR6

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Sensor protein CiaH

Gene

ciaH

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR.

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphorelay sensor kinase activity Source: InterPro

GO - Biological processi

  1. establishment of competence for transformation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Competence, Two-component regulatory system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-715-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sensor protein CiaH (EC:2.7.13.3)
Gene namesi
Name:ciaH
Ordered Locus Names:spr0708
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000586: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 444444Sensor protein CiaHPRO_0000074723Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei226 – 2261Phosphohistidine; by autocatalysisPROSITE-ProRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi171101.spr0708.

Structurei

3D structure databases

ProteinModelPortaliP0A4I6.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei183 – 20321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini223 – 438216Histidine kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 histidine kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0642.
HOGENOMiHOG000223177.
KOiK14982.
OMAiMIVFWLI.
OrthoDBiEOG6G4VQG.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003661. EnvZ-like_dim/P.
IPR003594. HATPase_C.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A4I6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSKLKKTWY ADDFSYFIRN FGVFTLIFST MTLIILQVMH SSLYTSVDDK
60 70 80 90 100
LHGLSENPQA VIQLAINRAT EEIKDLENAR ADASKVEIKP NVSSNTEVIL
110 120 130 140 150
FDKDFTQLLS GNRFLGLDKI KLEKKELGHI YQIQVFNSYG QEEIYRVILM
160 170 180 190 200
ETNISSVSTN IKYAAVLINT SQLEQASQKH EQLIVVVMAS FWILSLLASL
210 220 230 240 250
YLARVSVRPL LESMQKQQSF VENASHELRT PLAVLQNRLE TLFRKPEATI
260 270 280 290 300
MDVSESIASS LEEVRNMRFL TTSLLNLARR DDGIKPELAE VPTSFFNTTF
310 320 330 340 350
TNYEMIASEN NRVFRFENRI HRTIVTDQLL LKQLMTILFD NAVKYTEEDG
360 370 380 390 400
EIDFLISATD RNLYLLVSDN GIGISTEDKK KIFDRFYRVD KARTRQKGGF
410 420 430 440
GLGLSLAKQI VDALKGTVTV KDNKPKGTIF EVKIAIQTPS KKKK
Length:444
Mass (Da):50,673
Last modified:March 15, 2005 - v1
Checksum:i1D36CAE8D21D3337
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77249 Genomic DNA. Translation: CAA54466.1.
AE007317 Genomic DNA. Translation: AAK99512.1.
PIRiD97960.
S49545.
RefSeqiNP_358302.1. NC_003098.1.
WP_000491790.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAK99512; AAK99512; spr0708.
GeneIDi934244.
KEGGispr:spr0708.
PATRICi19701324. VBIStrPne107296_0784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77249 Genomic DNA. Translation: CAA54466.1 .
AE007317 Genomic DNA. Translation: AAK99512.1 .
PIRi D97960.
S49545.
RefSeqi NP_358302.1. NC_003098.1.
WP_000491790.1. NC_003098.1.

3D structure databases

ProteinModelPortali P0A4I6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 171101.spr0708.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK99512 ; AAK99512 ; spr0708 .
GeneIDi 934244.
KEGGi spr:spr0708.
PATRICi 19701324. VBIStrPne107296_0784.

Phylogenomic databases

eggNOGi COG0642.
HOGENOMi HOG000223177.
KOi K14982.
OMAi MIVFWLI.
OrthoDBi EOG6G4VQG.

Enzyme and pathway databases

BioCyci SPNE171101:GJC8-715-MONOMER.

Family and domain databases

Gene3Di 1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProi IPR003661. EnvZ-like_dim/P.
IPR003594. HATPase_C.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view ]
Pfami PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
[Graphical view ]
PRINTSi PR00344. BCTRLSENSOR.
SMARTi SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
[Graphical view ]
SUPFAMi SSF47384. SSF47384. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEi PS50109. HIS_KIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae."
    Guenzi E., Gasc A.M., Sicard M.A., Hakenbeck R.
    Mol. Microbiol. 12:505-515(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-255 / R6.

Entry informationi

Entry nameiCIAH_STRR6
AccessioniPrimary (citable) accession number: P0A4I6
Secondary accession number(s): Q54955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3