Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcriptional regulatory protein CiaR

Gene

ciaR

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi124 – 22299OmpR/PhoB-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Competence, Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-714-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein CiaR
Gene namesi
Name:ciaR
Ordered Locus Names:spr0707
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000586 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Transcriptional regulatory protein CiaRPRO_0000081062Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 5114-aspartylphosphatePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by CiaH.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP0A4H8.

Interactioni

Protein-protein interaction databases

STRINGi171101.spr0707.

Structurei

3D structure databases

ProteinModelPortaliP0A4H8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 116114Response regulatoryPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 OmpR/PhoB-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108STX. Bacteria.
COG0745. LUCA.
HOGENOMiHOG000034815.
KOiK14983.
OrthoDBiEOG6G4VQG.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A4H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKILLVEDD LGLSNSVFDF LDDFADVMQV FDGEEGLYEA ESGVYDLILL
60 70 80 90 100
DLMLPEKNGF QVLKELREKG ITTPVLIMTA KESLDDKGHG FELGADDYLT
110 120 130 140 150
KPFYLEELKM RIQALLKRSG KFNENTLTYG NIVVNLSTNT VKVEDTPVEL
160 170 180 190 200
LGKEFDLLVY FLQNQNVILP KTQIFDRLWG FDSDTTISVV EVYVSKVRKK
210 220
LKGTTFAENL QTLRSVGYLL KDVQ
Length:224
Mass (Da):25,466
Last modified:March 15, 2005 - v1
Checksum:i1CE646532B2E3A8F
GO

Sequence cautioni

The sequence AAK99511.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77249 Genomic DNA. Translation: CAA54465.1.
AE007317 Genomic DNA. Translation: AAK99511.1. Different initiation.
PIRiS49544.
RefSeqiNP_358301.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAK99511; AAK99511; spr0707.
GeneIDi934251.
KEGGispr:spr0707.
PATRICi19701322. VBIStrPne107296_0783.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77249 Genomic DNA. Translation: CAA54465.1.
AE007317 Genomic DNA. Translation: AAK99511.1. Different initiation.
PIRiS49544.
RefSeqiNP_358301.1. NC_003098.1.

3D structure databases

ProteinModelPortaliP0A4H8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi171101.spr0707.

Proteomic databases

PRIDEiP0A4H8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK99511; AAK99511; spr0707.
GeneIDi934251.
KEGGispr:spr0707.
PATRICi19701322. VBIStrPne107296_0783.

Phylogenomic databases

eggNOGiENOG4108STX. Bacteria.
COG0745. LUCA.
HOGENOMiHOG000034815.
KOiK14983.
OrthoDBiEOG6G4VQG.

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-714-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae."
    Guenzi E., Gasc A.M., Sicard M.A., Hakenbeck R.
    Mol. Microbiol. 12:505-515(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-255 / R6.

Entry informationi

Entry nameiCIAR_STRR6
AccessioniPrimary (citable) accession number: P0A4H8
Secondary accession number(s): Q54954
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 13, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.