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Protein

Virulence factors putative positive transcription regulator BvgA

Gene

bvgA

Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Member of the two-component regulatory system BvgS/BvgA. Activates the transcription of virulence genes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi166 – 18520H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system, Virulence

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBBRO257310:BB2994-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Virulence factors putative positive transcription regulator BvgA
Gene namesi
Name:bvgA
Ordered Locus Names:BB2994
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001027 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Virulence factors putative positive transcription regulator BvgAPRO_0000081032Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 5414-aspartylphosphatePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by BvgS.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi257310.BB2994.

Structurei

3D structure databases

ProteinModelPortaliP0A4H3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 119116Response regulatoryPROSITE-ProRule annotationAdd
BLAST
Domaini142 – 20766HTH luxR-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH luxR-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 response regulatory domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108WQH. Bacteria.
ENOG4111M1G. LUCA.
HOGENOMiHOG000034813.
KOiK07690.
OrthoDBiPOG091H05B9.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A4H3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYNKVLIIDD HPVLRFAVRV LMEKEGFEVI GETDNGIDGL KIAREKIPNL
60 70 80 90 100
VVLDIGIPKL DGLEVIARLQ SLGLPLRVLV LTGQPPSLFA RRCLNSGAAG
110 120 130 140 150
FVCKHENLHE VINAAKAVMA GYTYFPSTTL SEMRMGDNAK SDSTLISVLS
160 170 180 190 200
NRELTVLQLL AQGMSNKDIA DSMFLSNKTV STYKTRLLQK LNATSLVELI

DLAKRNNLA
Length:209
Mass (Da):22,952
Last modified:March 15, 2005 - v1
Checksum:i5D5B32BB2A69B23E
GO

Sequence cautioni

The sequence CAE33486 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58355 Genomic DNA. Translation: CAA41251.1.
BX640446 Genomic DNA. Translation: CAE33486.1. Different initiation.
PIRiS17943.
RefSeqiWP_010930609.1. NC_002927.3.

Genome annotation databases

EnsemblBacteriaiCAE33486; CAE33486; BB2994.
KEGGibbr:BB2994.
PATRICi21139343. VBIBorBro124907_3040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58355 Genomic DNA. Translation: CAA41251.1.
BX640446 Genomic DNA. Translation: CAE33486.1. Different initiation.
PIRiS17943.
RefSeqiWP_010930609.1. NC_002927.3.

3D structure databases

ProteinModelPortaliP0A4H3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257310.BB2994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAE33486; CAE33486; BB2994.
KEGGibbr:BB2994.
PATRICi21139343. VBIBorBro124907_3040.

Phylogenomic databases

eggNOGiENOG4108WQH. Bacteria.
ENOG4111M1G. LUCA.
HOGENOMiHOG000034813.
KOiK07690.
OrthoDBiPOG091H05B9.

Enzyme and pathway databases

BioCyciBBRO257310:BB2994-MONOMER.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBVGA_BORBR
AccessioniPrimary (citable) accession number: P0A4H3
Secondary accession number(s): P16574
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.