Virulence factors putative positive transcription regulator BvgA - Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

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P0A4H2 (BVGA_BORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 60. History...

Clusters with 100%, 90%, 50% identity |

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Virulence factors putative positive transcription regulator BvgA

Gene names

Name:	bvgA
Ordered Locus Names:	BP1878

Organism

Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) [Reference proteome] [HAMAP]

Taxonomic identifier

257313 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella ›

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Member of the two-component regulatory system BvgS/BvgA. Activates the transcription of virulence genes.
Subunit structure	Homodimer.
Post-translational modification	Phosphorylated by BvgS.
Sequence similarities	Contains 1 HTH luxR-type DNA-binding domain. Contains 1 response regulatory domain.
Mass spectrometry	Molecular mass is 22949 Da from positions 1 - 209. Determined by MALDI. Ref.6

Ontologies

Keywords
Biological process	Transcription Transcription regulation Two-component regulatory system Virulence
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: GOC pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorelay response regulator activity Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 209

209

Virulence factors putative positive transcription regulator BvgA

PRO_0000081034

Regions

Domain

1 – 119

119

Response regulatory

Domain

142 – 207

HTH luxR-type

DNA binding

166 – 185

H-T-H motif By similarity

Amino acid modifications

Modified residue

4-aspartylphosphate By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P0A4H2 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 5D5B32BB2A69B23E
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FASTA

209

22,952

        10         20         30         40         50         60 
MYNKVLIIDD HPVLRFAVRV LMEKEGFEVI GETDNGIDGL KIAREKIPNL VVLDIGIPKL 

        70         80         90        100        110        120 
DGLEVIARLQ SLGLPLRVLV LTGQPPSLFA RRCLNSGAAG FVCKHENLHE VINAAKAVMA 

       130        140        150        160        170        180 
GYTYFPSTTL SEMRMGDNAK SDSTLISVLS NRELTVLQLL AQGMSNKDIA DSMFLSNKTV 

       190        200 
STYKTRLLQK LNATSLVELI DLAKRNNLA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins." Arico B., Miller J.F., Roy C., Stibitz S., Monack D.M., Falkow S., Gross R., Rappuoli R. Proc. Natl. Acad. Sci. U.S.A. 86:6671-6675(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica." Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. Maskell D.J. Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tohama I / ATCC BAA-589 / NCTC 13251.
[3]	"Positive transcriptional feedback at the bvg locus controls expression of virulence factors in Bordetella pertussis." Scarlato V., Prugnola A., Arico B., Rappuoli R. Proc. Natl. Acad. Sci. U.S.A. 87:6753-6757(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-7.
[4]	"Autophosphorylation and phosphotransfer in the Bordetella pertussis BvgAS signal transduction cascade." Uhl M.A., Miller J.F. Proc. Natl. Acad. Sci. U.S.A. 91:1163-1167(1994) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[5]	"Specificity of the BvgAS and EvgAS phosphorelay is mediated by the C-terminal HPt domains of the sensor proteins." Perraud A.-L., Kimmel B., Weiss V., Gross R. Mol. Microbiol. 27:875-887(1998) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
[6]	"Dimerization of signalling modules of the EvgAS and BvgAS phosphorelay systems." Perraud A.-L., Rippe K., Bantscheff M., Glocker M., Lucassen M., Jung K., Sebald W., Weiss V., Gross R. Biochim. Biophys. Acta 1478:341-354(2000) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M25401 Genomic DNA. Translation: AAA22969.1. BX640416 Genomic DNA. Translation: CAE42161.1.
PIR	VZBRGP. B33729.
RefSeq	NP_880570.1. NC_002929.2.
3D structure databases
ProteinModelPortal	P0A4H2.
ModBase	Search...
Protein-protein interaction databases
STRING	257313.BP1878.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAE42161; CAE42161; BP1878.
GeneID	2667058.
KEGG	bpe:BP1878.
PATRIC	21157044. VBIBorPer7866_2017.
Phylogenomic databases
eggNOG	COG2197.
HOGENOM	HOG000034813.
KO	K07690.
OMA	HILLIMY.
ProtClustDB	CLSK434910.
Enzyme and pathway databases
BioCyc	BPER257313:BP1878-MONOMER.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR011006. CheY-like_superfamily. IPR001789. Sig_transdc_resp-reg_receiver. IPR000792. Tscrpt_reg_LuxR_C. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00196. GerE. 1 hit. PF00072. Response_reg. 1 hit. [Graphical view]
PRINTS	PR00038. HTHLUXR.
SMART	SM00421. HTH_LUXR. 1 hit. SM00448. REC. 1 hit. [Graphical view]
SUPFAM	SSF52172. CheY_like. 1 hit.
PROSITE	PS00622. HTH_LUXR_1. 1 hit. PS50043. HTH_LUXR_2. 1 hit. PS50110. RESPONSE_REGULATORY. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BVGA_BORPE

Accession

Primary (citable) accession number: P0A4H2
Secondary accession number(s): P16574

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents