Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P0A4H2 (BVGA_BORPE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Virulence factors putative positive transcription regulator BvgA
Gene names
Name:bvgA
Ordered Locus Names:BP1878
OrganismBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) [Reference proteome] [HAMAP]
Taxonomic identifier257313 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Member of the two-component regulatory system BvgS/BvgA. Activates the transcription of virulence genes.

Subunit structure

Homodimer.

Post-translational modification

Phosphorylated by BvgS.

Sequence similarities

Contains 1 HTH luxR-type DNA-binding domain.

Contains 1 response regulatory domain.

Mass spectrometry

Molecular mass is 22949 Da from positions 1 - 209. Determined by MALDI. Ref.6

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Virulence factors putative positive transcription regulator BvgA
PRO_0000081034

Regions

Domain1 – 119119Response regulatory
Domain142 – 20766HTH luxR-type
DNA binding166 – 18520H-T-H motif By similarity

Amino acid modifications

Modified residue5414-aspartylphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
P0A4H2 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 5D5B32BB2A69B23E

FASTA20922,952
        10         20         30         40         50         60 
MYNKVLIIDD HPVLRFAVRV LMEKEGFEVI GETDNGIDGL KIAREKIPNL VVLDIGIPKL 

        70         80         90        100        110        120 
DGLEVIARLQ SLGLPLRVLV LTGQPPSLFA RRCLNSGAAG FVCKHENLHE VINAAKAVMA 

       130        140        150        160        170        180 
GYTYFPSTTL SEMRMGDNAK SDSTLISVLS NRELTVLQLL AQGMSNKDIA DSMFLSNKTV 

       190        200 
STYKTRLLQK LNATSLVELI DLAKRNNLA 

« Hide

References

« Hide 'large scale' references
[1]"Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins."
Arico B., Miller J.F., Roy C., Stibitz S., Monack D.M., Falkow S., Gross R., Rappuoli R.
Proc. Natl. Acad. Sci. U.S.A. 86:6671-6675(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S. expand/collapse author list , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tohama I / ATCC BAA-589 / NCTC 13251.
[3]"Positive transcriptional feedback at the bvg locus controls expression of virulence factors in Bordetella pertussis."
Scarlato V., Prugnola A., Arico B., Rappuoli R.
Proc. Natl. Acad. Sci. U.S.A. 87:6753-6757(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-7.
[4]"Autophosphorylation and phosphotransfer in the Bordetella pertussis BvgAS signal transduction cascade."
Uhl M.A., Miller J.F.
Proc. Natl. Acad. Sci. U.S.A. 91:1163-1167(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[5]"Specificity of the BvgAS and EvgAS phosphorelay is mediated by the C-terminal HPt domains of the sensor proteins."
Perraud A.-L., Kimmel B., Weiss V., Gross R.
Mol. Microbiol. 27:875-887(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[6]"Dimerization of signalling modules of the EvgAS and BvgAS phosphorelay systems."
Perraud A.-L., Rippe K., Bantscheff M., Glocker M., Lucassen M., Jung K., Sebald W., Weiss V., Gross R.
Biochim. Biophys. Acta 1478:341-354(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M25401 Genomic DNA. Translation: AAA22969.1.
BX640416 Genomic DNA. Translation: CAE42161.1.
PIRVZBRGP. B33729.
RefSeqNP_880570.1. NC_002929.2.

3D structure databases

ProteinModelPortalP0A4H2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING257313.BP1878.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAE42161; CAE42161; BP1878.
GeneID2667058.
KEGGbpe:BP1878.
PATRIC21157044. VBIBorPer7866_2017.

Phylogenomic databases

eggNOGCOG2197.
HOGENOMHOG000034813.
KOK07690.
OMAQKTVRNH.
OrthoDBEOG69GZGV.

Enzyme and pathway databases

BioCycBPER257313:BP1878-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR011006. CheY-like_superfamily.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSPR00038. HTHLUXR.
SMARTSM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMSSF52172. SSF52172. 1 hit.
PROSITEPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBVGA_BORPE
AccessionPrimary (citable) accession number: P0A4H2
Secondary accession number(s): P16574
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families