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P0A4H2

- BVGA_BORPE

UniProt

P0A4H2 - BVGA_BORPE

Protein

Virulence factors putative positive transcription regulator BvgA

Gene

bvgA

Organism
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Member of the two-component regulatory system BvgS/BvgA. Activates the transcription of virulence genes.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi166 – 18520H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. phosphorelay response regulator activity Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: CACAO
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation, Two-component regulatory system, Virulence

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciBPER257313:BP1878-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Virulence factors putative positive transcription regulator BvgA
    Gene namesi
    Name:bvgA
    Ordered Locus Names:BP1878
    OrganismiBordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
    Taxonomic identifieri257313 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000002676: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Virulence factors putative positive transcription regulator BvgAPRO_0000081034Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei54 – 5414-aspartylphosphatePROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated by BvgS.

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Homodimer.

    Protein-protein interaction databases

    STRINGi257313.BP1878.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A4H2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 119119Response regulatoryPROSITE-ProRule annotationAdd
    BLAST
    Domaini142 – 20766HTH luxR-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH luxR-type DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 response regulatory domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2197.
    HOGENOMiHOG000034813.
    KOiK07690.
    OMAiQKTVRNH.
    OrthoDBiEOG69GZGV.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR011006. CheY-like_superfamily.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR000792. Tscrpt_reg_LuxR_C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00196. GerE. 1 hit.
    PF00072. Response_reg. 1 hit.
    [Graphical view]
    PRINTSiPR00038. HTHLUXR.
    SMARTiSM00421. HTH_LUXR. 1 hit.
    SM00448. REC. 1 hit.
    [Graphical view]
    SUPFAMiSSF52172. SSF52172. 1 hit.
    PROSITEiPS00622. HTH_LUXR_1. 1 hit.
    PS50043. HTH_LUXR_2. 1 hit.
    PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A4H2-1 [UniParc]FASTAAdd to Basket

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    MYNKVLIIDD HPVLRFAVRV LMEKEGFEVI GETDNGIDGL KIAREKIPNL    50
    VVLDIGIPKL DGLEVIARLQ SLGLPLRVLV LTGQPPSLFA RRCLNSGAAG 100
    FVCKHENLHE VINAAKAVMA GYTYFPSTTL SEMRMGDNAK SDSTLISVLS 150
    NRELTVLQLL AQGMSNKDIA DSMFLSNKTV STYKTRLLQK LNATSLVELI 200
    DLAKRNNLA 209
    Length:209
    Mass (Da):22,952
    Last modified:March 15, 2005 - v1
    Checksum:i5D5B32BB2A69B23E
    GO

    Mass spectrometryi

    Molecular mass is 22949 Da from positions 1 - 209. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25401 Genomic DNA. Translation: AAA22969.1.
    BX640416 Genomic DNA. Translation: CAE42161.1.
    PIRiB33729. VZBRGP.
    RefSeqiNP_880570.1. NC_002929.2.
    WP_010930609.1. NC_002929.2.

    Genome annotation databases

    EnsemblBacteriaiCAE42161; CAE42161; BP1878.
    GeneIDi2667058.
    KEGGibpe:BP1878.
    PATRICi21157044. VBIBorPer7866_2017.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M25401 Genomic DNA. Translation: AAA22969.1 .
    BX640416 Genomic DNA. Translation: CAE42161.1 .
    PIRi B33729. VZBRGP.
    RefSeqi NP_880570.1. NC_002929.2.
    WP_010930609.1. NC_002929.2.

    3D structure databases

    ProteinModelPortali P0A4H2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257313.BP1878.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE42161 ; CAE42161 ; BP1878 .
    GeneIDi 2667058.
    KEGGi bpe:BP1878.
    PATRICi 21157044. VBIBorPer7866_2017.

    Phylogenomic databases

    eggNOGi COG2197.
    HOGENOMi HOG000034813.
    KOi K07690.
    OMAi QKTVRNH.
    OrthoDBi EOG69GZGV.

    Enzyme and pathway databases

    BioCyci BPER257313:BP1878-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR011006. CheY-like_superfamily.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR000792. Tscrpt_reg_LuxR_C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00196. GerE. 1 hit.
    PF00072. Response_reg. 1 hit.
    [Graphical view ]
    PRINTSi PR00038. HTHLUXR.
    SMARTi SM00421. HTH_LUXR. 1 hit.
    SM00448. REC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52172. SSF52172. 1 hit.
    PROSITEi PS00622. HTH_LUXR_1. 1 hit.
    PS50043. HTH_LUXR_2. 1 hit.
    PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins."
      Arico B., Miller J.F., Roy C., Stibitz S., Monack D.M., Falkow S., Gross R., Rappuoli R.
      Proc. Natl. Acad. Sci. U.S.A. 86:6671-6675(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica."
      Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R., Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L., Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A., Achtman M., Atkin R., Baker S.
      , Basham D., Bason N., Cherevach I., Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T., Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S., Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E., Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S., Barrell B.G., Maskell D.J.
      Nat. Genet. 35:32-40(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tohama I / ATCC BAA-589 / NCTC 13251.
    3. "Positive transcriptional feedback at the bvg locus controls expression of virulence factors in Bordetella pertussis."
      Scarlato V., Prugnola A., Arico B., Rappuoli R.
      Proc. Natl. Acad. Sci. U.S.A. 87:6753-6757(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-7.
    4. "Autophosphorylation and phosphotransfer in the Bordetella pertussis BvgAS signal transduction cascade."
      Uhl M.A., Miller J.F.
      Proc. Natl. Acad. Sci. U.S.A. 91:1163-1167(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    5. "Specificity of the BvgAS and EvgAS phosphorelay is mediated by the C-terminal HPt domains of the sensor proteins."
      Perraud A.-L., Kimmel B., Weiss V., Gross R.
      Mol. Microbiol. 27:875-887(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    6. "Dimerization of signalling modules of the EvgAS and BvgAS phosphorelay systems."
      Perraud A.-L., Rippe K., Bantscheff M., Glocker M., Lucassen M., Jung K., Sebald W., Weiss V., Gross R.
      Biochim. Biophys. Acta 1478:341-354(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, MASS SPECTROMETRY.

    Entry informationi

    Entry nameiBVGA_BORPE
    AccessioniPrimary (citable) accession number: P0A4H2
    Secondary accession number(s): P16574
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3