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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Protein family/group databases

TCDBi3.A.5.4.1. the general secretory pathway (sec) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecYUniRule annotation
Gene namesi
Name:secYUniRule annotation
Ordered Locus Names:syc1883_d
OrganismiSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Taxonomic identifieri269084 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001175 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
  • Cellular thylakoid membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalUniRule annotationAdd BLAST21
Transmembranei73 – 93HelicalUniRule annotationAdd BLAST21
Transmembranei127 – 147HelicalUniRule annotationAdd BLAST21
Transmembranei156 – 176HelicalUniRule annotationAdd BLAST21
Transmembranei179 – 199HelicalUniRule annotationAdd BLAST21
Transmembranei220 – 240HelicalUniRule annotationAdd BLAST21
Transmembranei276 – 296HelicalUniRule annotationAdd BLAST21
Transmembranei318 – 338HelicalUniRule annotationAdd BLAST21
Transmembranei375 – 395HelicalUniRule annotationAdd BLAST21
Transmembranei401 – 421HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane, Thylakoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001317551 – 439Protein translocase subunit SecYAdd BLAST439

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.UniRule annotation

Protein-protein interaction databases

STRINGi269084.syc1883_d.

Structurei

3D structure databases

ProteinModelPortaliP0A4H1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0201. LUCA.
HOGENOMiHOG000080585.
KOiK03076.
OMAiQTYVISQ.
OrthoDBiPOG091H024M.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A4H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVSRGKTPN AQETFLQMAQ ASGLRGRILI TVGLLILCRL GIFIPVPGID
60 70 80 90 100
RVAFSNDLQG NANLGGVIGF LDIFSGGGLS ALGVFALGIL PYINASIILQ
110 120 130 140 150
LLTAAVPALE DLQKNEGEAG RRKIAQLTRY VSLGWALLQS IVIAVWVTRY
160 170 180 190 200
AVTPGPLFTI QTALALVAGS MFVMWISELI TERGIGNGAS LLIFLNIVAT
210 220 230 240 250
LPRSLQQTLE LAQSGDRSTV GGIVILLIVF LATIVGIVFV QEGTRRIPVV
260 270 280 290 300
SARRQVGNRV YSERSSYLPL RLNQGGVMPI IFASAILVLP FSLANFTSNE
310 320 330 340 350
VVLRIANYLS PNGPTPWIYA LFYLVLIVAF SYFYSSLILN PVDLAQNLKK
360 370 380 390 400
MGSSIPGVRP GRATSQYVQG VLNRLTILGA VFLGLVAIIP TAVEGATRIR
410 420 430
TFQGFGATSL LILVGVAIDT AKQVQTYVIS QRYEGMVKD
Length:439
Mass (Da):47,151
Last modified:March 15, 2005 - v1
Checksum:iC4626776A171E9BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000111 Genomic DNA. Translation: BAA22467.1.
AP008231 Genomic DNA. Translation: BAD80073.1.
RefSeqiWP_011244193.1. NC_006576.1.

Genome annotation databases

EnsemblBacteriaiBAD80073; BAD80073; syc1883_d.
KEGGisyc:syc1883_d.
PATRICi32489831. VBISynElo117686_2150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000111 Genomic DNA. Translation: BAA22467.1.
AP008231 Genomic DNA. Translation: BAD80073.1.
RefSeqiWP_011244193.1. NC_006576.1.

3D structure databases

ProteinModelPortaliP0A4H1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269084.syc1883_d.

Protein family/group databases

TCDBi3.A.5.4.1. the general secretory pathway (sec) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD80073; BAD80073; syc1883_d.
KEGGisyc:syc1883_d.
PATRICi32489831. VBISynElo117686_2150.

Phylogenomic databases

eggNOGiCOG0201. LUCA.
HOGENOMiHOG000080585.
KOiK03076.
OMAiQTYVISQ.
OrthoDBiPOG091H024M.

Family and domain databases

Gene3Di1.10.3370.10. 1 hit.
HAMAPiMF_01465. SecY. 1 hit.
InterProiIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR030659. SecY_CS.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERiPTHR10906. PTHR10906. 1 hit.
PfamiPF00344. SecY. 1 hit.
[Graphical view]
PIRSFiPIRSF004557. SecY. 1 hit.
SUPFAMiSSF103491. SSF103491. 1 hit.
TIGRFAMsiTIGR00967. 3a0501s007. 1 hit.
PROSITEiPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECY_SYNP6
AccessioniPrimary (citable) accession number: P0A4H1
Secondary accession number(s): P31159
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.