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P0A4G4 (MTSA_STRP1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Metal ABC transporter substrate-binding lipoprotein
Gene names
Name:mtsA
Ordered Locus Names:SPy_0453, M5005_Spy0368
OrganismStreptococcus pyogenes serotype M1 [Complete proteome] [HAMAP]
Taxonomic identifier301447 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Part of an ATP-driven transport system for a metal; this protein has affinity for Zn2+, Fe3+ and Cu2+.

Subcellular location

Cell membrane; Lipid-anchor.

Sequence similarities

Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily.

Sequence caution

The sequence AAZ50986.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Probable
Chain21 – 310290Metal ABC transporter substrate-binding lipoprotein
PRO_0000031894

Sites

Metal binding681Zinc By similarity
Metal binding1401Zinc By similarity
Metal binding2061Zinc By similarity
Metal binding2811Zinc By similarity

Amino acid modifications

Lipidation211N-palmitoyl cysteine Probable
Lipidation211S-diacylglycerol cysteine Probable

Natural variations

Natural variant771V → A in strain: AP1.

Experimental info

Sequence conflict261T → A in AAD56936. Ref.1
Sequence conflict261T → A in AAD56939. Ref.1
Sequence conflict301K → E in AAD56936. Ref.1
Sequence conflict441A → G in AAD56936. Ref.1
Sequence conflict49 – 502AI → VM in AAD56936. Ref.1

Secondary structure

.............................................. 310
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0A4G4 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: B0F829EF1C72CADC

FASTA31034,358
        10         20         30         40         50         60 
MGKRMSLILG AFLSVFLLVA CSSTGTKTAK SDKLKVVATN SIIADMTKAI AGDKIDLHSI 

        70         80         90        100        110        120 
VPIGQDPHEY EPLPEDVEKT SNADVIFYNG INLEDGGQAW FTKLVKNAQK TKNKDYFAVS 

       130        140        150        160        170        180 
DGIDVIYLEG ASEKGKEDPH AWLNLENGII YSKNIAKQLI AKDPKNKETY EKNLKAYVAK 

       190        200        210        220        230        240 
LEKLDKEAKS KFDAIAENKK LIVTSEGCFK YFSKAYGVPS AYIWEINTEE EGTPDQISSL 

       250        260        270        280        290        300 
IEKLKVIKPS ALFVESSVDR RPMETVSKDS GIPIYSEIFT DSIAKKGKPG DSYYAMMKWN 

       310 
LDKISEGLAK 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of a Streptococcus pyogenes ABC transporter with multiple specificity for metal cations."
Janulczyk R., Pallon J., Bjoerck L.
Mol. Microbiol. 34:596-606(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 30-39, CHARACTERIZATION.
Strain: AP1 / Serotype M1 and ATCC 700294 / SF370 / Serotype M1.
[2]"Complete genome sequence of an M1 strain of Streptococcus pyogenes."
Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K., Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P., Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L. expand/collapse author list , White J., Yuan X., Clifton S.W., Roe B.A., McLaughlin R.E.
Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700294 / SF370 / Serotype M1.
[3]"Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF180520 Genomic DNA. Translation: AAD56936.1.
AF180521 Genomic DNA. Translation: AAD56939.1.
AE004092 Genomic DNA. Translation: AAK33468.1.
CP000017 Genomic DNA. Translation: AAZ50986.1. Different initiation.
RefSeqNP_268747.1. NC_002737.1.
YP_281731.1. NC_007297.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3HH8X-ray1.87A22-310[»]
ProteinModelPortalP0A4G4.
SMRP0A4G4. Positions 28-310.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING160490.SPy_0453.

Protein family/group databases

TCDB3.A.1.15.6. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbP0A4G4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK33468; AAK33468; SPy_0453.
AAZ50986; AAZ50986; M5005_Spy0368.
GeneID3572540.
900696.
KEGGspy:SPy_0453.
spz:M5005_Spy_0368.
PATRIC19714627. VBIStrPyo79812_0382.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0803.
HOGENOMHOG000180309.
KOK11704.
OMAWEVNTES.
OrthoDBEOG6B3601.

Enzyme and pathway databases

BioCycSPYO160490:GJ81-381-MONOMER.
SPYO293653:GHFC-423-MONOMER.

Family and domain databases

InterProIPR006129. AdhesinB.
IPR006128. Lipoprotein_4.
IPR006127. Perip_solute-bd_prot_fam.
[Graphical view]
PfamPF01297. TroA. 1 hit.
[Graphical view]
PRINTSPR00691. ADHESINB.
PR00690. ADHESNFAMILY.
PROSITEPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP0A4G4.

Entry information

Entry nameMTSA_STRP1
AccessionPrimary (citable) accession number: P0A4G4
Secondary accession number(s): Q490I2 expand/collapse secondary AC list , Q9A157, Q9RNI7, Q9RNJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references