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P0A4G4

- MTSA_STRP1

UniProt

P0A4G4 - MTSA_STRP1

Protein

Metal ABC transporter substrate-binding lipoprotein

Gene

mtsA

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Part of an ATP-driven transport system for a metal; this protein has affinity for Zn2+, Fe3+ and Cu2+.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi68 – 681ZincBy similarity
    Metal bindingi140 – 1401ZincBy similarity
    Metal bindingi206 – 2061ZincBy similarity
    Metal bindingi281 – 2811ZincBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell adhesion Source: InterPro
    2. copper ion transport Source: UniProtKB-KW
    3. iron ion homeostasis Source: UniProtKB-KW
    4. zinc ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Copper transport, Ion transport, Iron transport, Transport, Zinc transport

    Keywords - Ligandi

    Copper, Iron, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciSPYO160490:GJ81-381-MONOMER.
    SPYO293653:GHFC-423-MONOMER.

    Protein family/group databases

    TCDBi3.A.1.15.6. the atp-binding cassette (abc) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Metal ABC transporter substrate-binding lipoprotein
    Gene namesi
    Name:mtsA
    Ordered Locus Names:SPy_0453, M5005_Spy0368
    OrganismiStreptococcus pyogenes serotype M1
    Taxonomic identifieri301447 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020CuratedAdd
    BLAST
    Chaini21 – 310290Metal ABC transporter substrate-binding lipoproteinPRO_0000031894Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi21 – 211N-palmitoyl cysteineCurated
    Lipidationi21 – 211S-diacylglycerol cysteineCurated

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP0A4G4.

    Interactioni

    Protein-protein interaction databases

    STRINGi160490.SPy_0453.

    Structurei

    Secondary structure

    1
    310
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi33 – 408
    Helixi41 – 5111
    Helixi52 – 543
    Beta strandi55 – 595
    Beta strandi67 – 693
    Helixi74 – 829
    Beta strandi84 – 885
    Helixi100 – 1078
    Turni112 – 1143
    Beta strandi115 – 1184
    Turni119 – 1224
    Helixi141 – 1433
    Helixi145 – 16218
    Helixi164 – 1663
    Helixi167 – 19024
    Turni191 – 1944
    Helixi197 – 1993
    Beta strandi202 – 2076
    Helixi210 – 2167
    Beta strandi220 – 2267
    Helixi234 – 24613
    Beta strandi252 – 2554
    Helixi261 – 27010
    Beta strandi274 – 2785
    Beta strandi280 – 2823
    Helixi293 – 30816

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3HH8X-ray1.87A22-310[»]
    ProteinModelPortaliP0A4G4.
    SMRiP0A4G4. Positions 28-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0A4G4.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0803.
    HOGENOMiHOG000180309.
    KOiK11704.
    OMAiWEVNTES.
    OrthoDBiEOG6B3601.

    Family and domain databases

    InterProiIPR006129. AdhesinB.
    IPR006128. Lipoprotein_4.
    IPR006127. Perip_solute-bd_prot_fam.
    [Graphical view]
    PfamiPF01297. TroA. 1 hit.
    [Graphical view]
    PRINTSiPR00691. ADHESINB.
    PR00690. ADHESNFAMILY.
    PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0A4G4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKRMSLILG AFLSVFLLVA CSSTGTKTAK SDKLKVVATN SIIADMTKAI    50
    AGDKIDLHSI VPIGQDPHEY EPLPEDVEKT SNADVIFYNG INLEDGGQAW 100
    FTKLVKNAQK TKNKDYFAVS DGIDVIYLEG ASEKGKEDPH AWLNLENGII 150
    YSKNIAKQLI AKDPKNKETY EKNLKAYVAK LEKLDKEAKS KFDAIAENKK 200
    LIVTSEGCFK YFSKAYGVPS AYIWEINTEE EGTPDQISSL IEKLKVIKPS 250
    ALFVESSVDR RPMETVSKDS GIPIYSEIFT DSIAKKGKPG DSYYAMMKWN 300
    LDKISEGLAK 310
    Length:310
    Mass (Da):34,358
    Last modified:March 15, 2005 - v1
    Checksum:iB0F829EF1C72CADC
    GO

    Sequence cautioni

    The sequence AAZ50986.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261T → A in AAD56936. (PubMed:10564500)Curated
    Sequence conflicti26 – 261T → A in AAD56939. (PubMed:10564500)Curated
    Sequence conflicti30 – 301K → E in AAD56936. (PubMed:10564500)Curated
    Sequence conflicti44 – 441A → G in AAD56936. (PubMed:10564500)Curated
    Sequence conflicti49 – 502AI → VM in AAD56936. (PubMed:10564500)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771V → A in strain: AP1.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF180520 Genomic DNA. Translation: AAD56936.1.
    AF180521 Genomic DNA. Translation: AAD56939.1.
    AE004092 Genomic DNA. Translation: AAK33468.1.
    CP000017 Genomic DNA. Translation: AAZ50986.1. Different initiation.
    RefSeqiNP_268747.1. NC_002737.1.
    YP_281731.1. NC_007297.1.

    Genome annotation databases

    EnsemblBacteriaiAAK33468; AAK33468; SPy_0453.
    AAZ50986; AAZ50986; M5005_Spy0368.
    GeneIDi3572540.
    900696.
    KEGGispy:SPy_0453.
    spz:M5005_Spy_0368.
    PATRICi19714627. VBIStrPyo79812_0382.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF180520 Genomic DNA. Translation: AAD56936.1 .
    AF180521 Genomic DNA. Translation: AAD56939.1 .
    AE004092 Genomic DNA. Translation: AAK33468.1 .
    CP000017 Genomic DNA. Translation: AAZ50986.1 . Different initiation.
    RefSeqi NP_268747.1. NC_002737.1.
    YP_281731.1. NC_007297.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3HH8 X-ray 1.87 A 22-310 [» ]
    ProteinModelPortali P0A4G4.
    SMRi P0A4G4. Positions 28-310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 160490.SPy_0453.

    Protein family/group databases

    TCDBi 3.A.1.15.6. the atp-binding cassette (abc) superfamily.

    Proteomic databases

    PaxDbi P0A4G4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK33468 ; AAK33468 ; SPy_0453 .
    AAZ50986 ; AAZ50986 ; M5005_Spy0368 .
    GeneIDi 3572540.
    900696.
    KEGGi spy:SPy_0453.
    spz:M5005_Spy_0368.
    PATRICi 19714627. VBIStrPyo79812_0382.

    Phylogenomic databases

    eggNOGi COG0803.
    HOGENOMi HOG000180309.
    KOi K11704.
    OMAi WEVNTES.
    OrthoDBi EOG6B3601.

    Enzyme and pathway databases

    BioCyci SPYO160490:GJ81-381-MONOMER.
    SPYO293653:GHFC-423-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P0A4G4.

    Family and domain databases

    InterProi IPR006129. AdhesinB.
    IPR006128. Lipoprotein_4.
    IPR006127. Perip_solute-bd_prot_fam.
    [Graphical view ]
    Pfami PF01297. TroA. 1 hit.
    [Graphical view ]
    PRINTSi PR00691. ADHESINB.
    PR00690. ADHESNFAMILY.
    PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a Streptococcus pyogenes ABC transporter with multiple specificity for metal cations."
      Janulczyk R., Pallon J., Bjoerck L.
      Mol. Microbiol. 34:596-606(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 30-39, CHARACTERIZATION.
      Strain: AP1 / Serotype M1 and ATCC 700294 / SF370 / Serotype M1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700294 / SF370 / Serotype M1.
    3. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
      Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
      J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

    Entry informationi

    Entry nameiMTSA_STRP1
    AccessioniPrimary (citable) accession number: P0A4G4
    Secondary accession number(s): Q490I2
    , Q9A157, Q9RNI7, Q9RNJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3