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P0A4G4

- MTSA_STRP1

UniProt

P0A4G4 - MTSA_STRP1

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Protein
Metal ABC transporter substrate-binding lipoprotein
Gene
mtsA, SPy_0453, M5005_Spy0368
Organism
Streptococcus pyogenes serotype M1
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Part of an ATP-driven transport system for a metal; this protein has affinity for Zn2+, Fe3+ and Cu2+.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681Zinc By similarity
Metal bindingi140 – 1401Zinc By similarity
Metal bindingi206 – 2061Zinc By similarity
Metal bindingi281 – 2811Zinc By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. cell adhesion Source: InterPro
  2. copper ion transport Source: UniProtKB-KW
  3. iron ion homeostasis Source: UniProtKB-KW
  4. zinc ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Copper transport, Ion transport, Iron transport, Transport, Zinc transport

Keywords - Ligandi

Copper, Iron, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSPYO160490:GJ81-381-MONOMER.
SPYO293653:GHFC-423-MONOMER.

Protein family/group databases

TCDBi3.A.1.15.6. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Metal ABC transporter substrate-binding lipoprotein
Gene namesi
Name:mtsA
Ordered Locus Names:SPy_0453, M5005_Spy0368
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000750: Chromosome, UP000002702: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Inferred
Add
BLAST
Chaini21 – 310290Metal ABC transporter substrate-binding lipoprotein
PRO_0000031894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi21 – 211N-palmitoyl cysteine Inferred
Lipidationi21 – 211S-diacylglycerol cysteine Inferred

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP0A4G4.

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_0453.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 408
Helixi41 – 5111
Helixi52 – 543
Beta strandi55 – 595
Beta strandi67 – 693
Helixi74 – 829
Beta strandi84 – 885
Helixi100 – 1078
Turni112 – 1143
Beta strandi115 – 1184
Turni119 – 1224
Helixi141 – 1433
Helixi145 – 16218
Helixi164 – 1663
Helixi167 – 19024
Turni191 – 1944
Helixi197 – 1993
Beta strandi202 – 2076
Helixi210 – 2167
Beta strandi220 – 2267
Helixi234 – 24613
Beta strandi252 – 2554
Helixi261 – 27010
Beta strandi274 – 2785
Beta strandi280 – 2823
Helixi293 – 30816

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HH8X-ray1.87A22-310[»]
ProteinModelPortaliP0A4G4.
SMRiP0A4G4. Positions 28-310.

Miscellaneous databases

EvolutionaryTraceiP0A4G4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0803.
HOGENOMiHOG000180309.
KOiK11704.
OMAiWEVNTES.
OrthoDBiEOG6B3601.

Family and domain databases

InterProiIPR006129. AdhesinB.
IPR006128. Lipoprotein_4.
IPR006127. Perip_solute-bd_prot_fam.
[Graphical view]
PfamiPF01297. TroA. 1 hit.
[Graphical view]
PRINTSiPR00691. ADHESINB.
PR00690. ADHESNFAMILY.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A4G4-1 [UniParc]FASTAAdd to Basket

« Hide

MGKRMSLILG AFLSVFLLVA CSSTGTKTAK SDKLKVVATN SIIADMTKAI    50
AGDKIDLHSI VPIGQDPHEY EPLPEDVEKT SNADVIFYNG INLEDGGQAW 100
FTKLVKNAQK TKNKDYFAVS DGIDVIYLEG ASEKGKEDPH AWLNLENGII 150
YSKNIAKQLI AKDPKNKETY EKNLKAYVAK LEKLDKEAKS KFDAIAENKK 200
LIVTSEGCFK YFSKAYGVPS AYIWEINTEE EGTPDQISSL IEKLKVIKPS 250
ALFVESSVDR RPMETVSKDS GIPIYSEIFT DSIAKKGKPG DSYYAMMKWN 300
LDKISEGLAK 310
Length:310
Mass (Da):34,358
Last modified:March 15, 2005 - v1
Checksum:iB0F829EF1C72CADC
GO

Sequence cautioni

The sequence AAZ50986.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771V → A in strain: AP1.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261T → A in AAD56936. 1 Publication
Sequence conflicti26 – 261T → A in AAD56939. 1 Publication
Sequence conflicti30 – 301K → E in AAD56936. 1 Publication
Sequence conflicti44 – 441A → G in AAD56936. 1 Publication
Sequence conflicti49 – 502AI → VM in AAD56936. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF180520 Genomic DNA. Translation: AAD56936.1.
AF180521 Genomic DNA. Translation: AAD56939.1.
AE004092 Genomic DNA. Translation: AAK33468.1.
CP000017 Genomic DNA. Translation: AAZ50986.1. Different initiation.
RefSeqiNP_268747.1. NC_002737.1.
YP_281731.1. NC_007297.1.

Genome annotation databases

EnsemblBacteriaiAAK33468; AAK33468; SPy_0453.
AAZ50986; AAZ50986; M5005_Spy0368.
GeneIDi3572540.
900696.
KEGGispy:SPy_0453.
spz:M5005_Spy_0368.
PATRICi19714627. VBIStrPyo79812_0382.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF180520 Genomic DNA. Translation: AAD56936.1 .
AF180521 Genomic DNA. Translation: AAD56939.1 .
AE004092 Genomic DNA. Translation: AAK33468.1 .
CP000017 Genomic DNA. Translation: AAZ50986.1 . Different initiation.
RefSeqi NP_268747.1. NC_002737.1.
YP_281731.1. NC_007297.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3HH8 X-ray 1.87 A 22-310 [» ]
ProteinModelPortali P0A4G4.
SMRi P0A4G4. Positions 28-310.
ModBasei Search...

Protein-protein interaction databases

STRINGi 160490.SPy_0453.

Protein family/group databases

TCDBi 3.A.1.15.6. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbi P0A4G4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK33468 ; AAK33468 ; SPy_0453 .
AAZ50986 ; AAZ50986 ; M5005_Spy0368 .
GeneIDi 3572540.
900696.
KEGGi spy:SPy_0453.
spz:M5005_Spy_0368.
PATRICi 19714627. VBIStrPyo79812_0382.

Phylogenomic databases

eggNOGi COG0803.
HOGENOMi HOG000180309.
KOi K11704.
OMAi WEVNTES.
OrthoDBi EOG6B3601.

Enzyme and pathway databases

BioCyci SPYO160490:GJ81-381-MONOMER.
SPYO293653:GHFC-423-MONOMER.

Miscellaneous databases

EvolutionaryTracei P0A4G4.

Family and domain databases

InterProi IPR006129. AdhesinB.
IPR006128. Lipoprotein_4.
IPR006127. Perip_solute-bd_prot_fam.
[Graphical view ]
Pfami PF01297. TroA. 1 hit.
[Graphical view ]
PRINTSi PR00691. ADHESINB.
PR00690. ADHESNFAMILY.
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a Streptococcus pyogenes ABC transporter with multiple specificity for metal cations."
    Janulczyk R., Pallon J., Bjoerck L.
    Mol. Microbiol. 34:596-606(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 30-39, CHARACTERIZATION.
    Strain: AP1 / Serotype M1 and ATCC 700294 / SF370 / Serotype M1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700294 / SF370 / Serotype M1.
  3. "Evolutionary origin and emergence of a highly successful clone of serotype M1 group A Streptococcus involved multiple horizontal gene transfer events."
    Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K., Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P., Musser J.M.
    J. Infect. Dis. 192:771-782(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-947 / MGAS5005 / Serotype M1.

Entry informationi

Entry nameiMTSA_STRP1
AccessioniPrimary (citable) accession number: P0A4G4
Secondary accession number(s): Q490I2
, Q9A157, Q9RNI7, Q9RNJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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