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Protein

Metal ABC transporter substrate-binding lipoprotein

Gene

mtsA

Organism
Streptococcus pyogenes serotype M1
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of an ATP-driven transport system for a metal; this protein has affinity for Zn2+, Fe3+ and Cu2+.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68ZincBy similarity1
Metal bindingi140ZincBy similarity1
Metal bindingi206ZincBy similarity1
Metal bindingi281ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Copper transport, Ion transport, Iron transport, Transport, Zinc transport

Keywords - Ligandi

Copper, Iron, Metal-binding, Zinc

Protein family/group databases

TCDBi3.A.1.15.6. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Metal ABC transporter substrate-binding lipoprotein
Gene namesi
Name:mtsA
Ordered Locus Names:SPy_0453, M5005_Spy0368
OrganismiStreptococcus pyogenes serotype M1
Taxonomic identifieri301447 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000750 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20CuratedAdd BLAST20
ChainiPRO_000003189421 – 310Metal ABC transporter substrate-binding lipoproteinAdd BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi21N-palmitoyl cysteineCurated1
Lipidationi21S-diacylglycerol cysteineCurated1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiP0A4G4.
PRIDEiP0A4G4.

Interactioni

Protein-protein interaction databases

STRINGi160490.SPy_0453.

Structurei

Secondary structure

1310
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 40Combined sources8
Helixi41 – 51Combined sources11
Helixi52 – 54Combined sources3
Beta strandi55 – 59Combined sources5
Beta strandi67 – 69Combined sources3
Helixi74 – 82Combined sources9
Beta strandi84 – 88Combined sources5
Helixi100 – 107Combined sources8
Turni112 – 114Combined sources3
Beta strandi115 – 118Combined sources4
Turni119 – 122Combined sources4
Helixi141 – 143Combined sources3
Helixi145 – 162Combined sources18
Helixi164 – 166Combined sources3
Helixi167 – 190Combined sources24
Turni191 – 194Combined sources4
Helixi197 – 199Combined sources3
Beta strandi202 – 207Combined sources6
Helixi210 – 216Combined sources7
Beta strandi220 – 226Combined sources7
Helixi234 – 246Combined sources13
Beta strandi252 – 255Combined sources4
Helixi261 – 270Combined sources10
Beta strandi274 – 278Combined sources5
Beta strandi280 – 282Combined sources3
Helixi293 – 308Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HH8X-ray1.87A22-310[»]
ProteinModelPortaliP0A4G4.
SMRiP0A4G4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A4G4.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105DSE. Bacteria.
COG0803. LUCA.
HOGENOMiHOG000180309.
KOiK11704.
OMAiHAWQNVA.

Family and domain databases

InterProiIPR006129. AdhesinB.
IPR006128. Lipoprotein_4.
IPR006127. ZnuA-like.
[Graphical view]
PfamiPF01297. ZnuA. 1 hit.
[Graphical view]
PRINTSiPR00691. ADHESINB.
PR00690. ADHESNFAMILY.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A4G4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKRMSLILG AFLSVFLLVA CSSTGTKTAK SDKLKVVATN SIIADMTKAI
60 70 80 90 100
AGDKIDLHSI VPIGQDPHEY EPLPEDVEKT SNADVIFYNG INLEDGGQAW
110 120 130 140 150
FTKLVKNAQK TKNKDYFAVS DGIDVIYLEG ASEKGKEDPH AWLNLENGII
160 170 180 190 200
YSKNIAKQLI AKDPKNKETY EKNLKAYVAK LEKLDKEAKS KFDAIAENKK
210 220 230 240 250
LIVTSEGCFK YFSKAYGVPS AYIWEINTEE EGTPDQISSL IEKLKVIKPS
260 270 280 290 300
ALFVESSVDR RPMETVSKDS GIPIYSEIFT DSIAKKGKPG DSYYAMMKWN
310
LDKISEGLAK
Length:310
Mass (Da):34,358
Last modified:March 15, 2005 - v1
Checksum:iB0F829EF1C72CADC
GO

Sequence cautioni

The sequence AAZ50986 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26T → A in AAD56936 (PubMed:10564500).Curated1
Sequence conflicti26T → A in AAD56939 (PubMed:10564500).Curated1
Sequence conflicti30K → E in AAD56936 (PubMed:10564500).Curated1
Sequence conflicti44A → G in AAD56936 (PubMed:10564500).Curated1
Sequence conflicti49 – 50AI → VM in AAD56936 (PubMed:10564500).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti77V → A in strain: AP1. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180520 Genomic DNA. Translation: AAD56936.1.
AF180521 Genomic DNA. Translation: AAD56939.1.
AE004092 Genomic DNA. Translation: AAK33468.1.
CP000017 Genomic DNA. Translation: AAZ50986.1. Different initiation.
RefSeqiNP_268747.1. NC_002737.2.

Genome annotation databases

EnsemblBacteriaiAAK33468; AAK33468; SPy_0453.
AAZ50986; AAZ50986; M5005_Spy0368.
GeneIDi900696.
KEGGispy:SPy_0453.
spz:M5005_Spy0368.
PATRICi19714627. VBIStrPyo79812_0382.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF180520 Genomic DNA. Translation: AAD56936.1.
AF180521 Genomic DNA. Translation: AAD56939.1.
AE004092 Genomic DNA. Translation: AAK33468.1.
CP000017 Genomic DNA. Translation: AAZ50986.1. Different initiation.
RefSeqiNP_268747.1. NC_002737.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3HH8X-ray1.87A22-310[»]
ProteinModelPortaliP0A4G4.
SMRiP0A4G4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi160490.SPy_0453.

Protein family/group databases

TCDBi3.A.1.15.6. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP0A4G4.
PRIDEiP0A4G4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK33468; AAK33468; SPy_0453.
AAZ50986; AAZ50986; M5005_Spy0368.
GeneIDi900696.
KEGGispy:SPy_0453.
spz:M5005_Spy0368.
PATRICi19714627. VBIStrPyo79812_0382.

Phylogenomic databases

eggNOGiENOG4105DSE. Bacteria.
COG0803. LUCA.
HOGENOMiHOG000180309.
KOiK11704.
OMAiHAWQNVA.

Miscellaneous databases

EvolutionaryTraceiP0A4G4.

Family and domain databases

InterProiIPR006129. AdhesinB.
IPR006128. Lipoprotein_4.
IPR006127. ZnuA-like.
[Graphical view]
PfamiPF01297. ZnuA. 1 hit.
[Graphical view]
PRINTSiPR00691. ADHESINB.
PR00690. ADHESNFAMILY.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTSA_STRP1
AccessioniPrimary (citable) accession number: P0A4G4
Secondary accession number(s): Q490I2
, Q9A157, Q9RNI7, Q9RNJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.