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Protein

Manganese ABC transporter substrate-binding lipoprotein

Gene

psaA

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of an ATP-driven transport system for manganese. Also act as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67ZincCurated1
Metal bindingi139ZincCurated1
Metal bindingi205ZincCurated1
Metal bindingi280ZincCurated1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Manganese, Metal-binding, Zinc

Protein family/group databases

TCDBi3.A.1.15.14. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Manganese ABC transporter substrate-binding lipoprotein
Alternative name(s):
Pneumococcal surface adhesin A
Gene namesi
Name:psaA
Ordered Locus Names:SP_1650
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

  • Cell membrane PROSITE-ProRule annotation; Lipid-anchor PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19CuratedAdd BLAST19
ChainiPRO_000003189120 – 309Manganese ABC transporter substrate-binding lipoproteinAdd BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi20N-palmitoyl cysteineCurated1
Lipidationi20S-diacylglycerol cysteineCurated1

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi170187.SpneT_02000954.

Structurei

Secondary structure

1309
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi27 – 29Combined sources3
Beta strandi33 – 39Combined sources7
Helixi40 – 50Combined sources11
Helixi51 – 53Combined sources3
Beta strandi54 – 60Combined sources7
Beta strandi66 – 68Combined sources3
Helixi73 – 81Combined sources9
Beta strandi83 – 87Combined sources5
Turni90 – 94Combined sources5
Turni96 – 98Combined sources3
Helixi99 – 106Combined sources8
Turni111 – 113Combined sources3
Beta strandi114 – 117Combined sources4
Turni118 – 121Combined sources4
Helixi127 – 129Combined sources3
Helixi140 – 142Combined sources3
Helixi144 – 161Combined sources18
Helixi163 – 165Combined sources3
Helixi166 – 193Combined sources28
Helixi196 – 198Combined sources3
Beta strandi201 – 206Combined sources6
Helixi209 – 215Combined sources7
Beta strandi219 – 223Combined sources5
Helixi233 – 244Combined sources12
Beta strandi251 – 254Combined sources4
Helixi260 – 269Combined sources10
Beta strandi273 – 277Combined sources5
Beta strandi279 – 281Combined sources3
Helixi292 – 307Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PSZX-ray2.00A19-309[»]
3ZK7X-ray1.69A/B32-309[»]
3ZK8X-ray1.65A/B32-309[»]
3ZK9X-ray1.45A/B32-309[»]
3ZKAX-ray1.55A/B32-309[»]
3ZTTX-ray2.70A/B/C/D19-309[»]
4UTOX-ray1.55A/B1-309[»]
4UTPX-ray2.00A/B1-309[»]
ProteinModelPortaliP0A4G2.
SMRiP0A4G2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A4G2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105DSE. Bacteria.
COG0803. LUCA.
KOiK19971.
OMAiHAWQNVA.

Family and domain databases

InterProiIPR006129. AdhesinB.
IPR006128. Lipoprotein_4.
IPR006127. ZnuA-like.
[Graphical view]
PfamiPF01297. ZnuA. 1 hit.
[Graphical view]
PRINTSiPR00691. ADHESINB.
PR00690. ADHESNFAMILY.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A4G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLGTLLVL FLSAIILVAC ASGKKDTTSG QKLKVVATNS IIADITKNIA
60 70 80 90 100
GDKIDLHSIV PIGQDPHEYE PLPEDVKKTS EADLIFYNGI NLETGGNAWF
110 120 130 140 150
TKLVENAKKT ENKDYFAVSD GVDVIYLEGQ NEKGKEDPHA WLNLENGIIF
160 170 180 190 200
AKNIAKQLSA KDPNNKEFYE KNLKEYTDKL DKLDKESKDK FNKIPAEKKL
210 220 230 240 250
IVTSEGAFKY FSKAYGVPSA YIWEINTEEE GTPEQIKTLV EKLRQTKVPS
260 270 280 290 300
LFVESSVDDR PMKTVSQDTN IPIYAQIFTD SIAEQGKEGD SYYSMMKYNL

DKIAEGLAK
Length:309
Mass (Da):34,594
Last modified:March 15, 2005 - v1
Checksum:iB125E7FE3DA6F67C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti8L → F in strain: NA-1508/92. 1
Natural varianti9V → I in strain: NA-1064/97. 1
Natural varianti14A → V in strain: NA-1064/97, NA-1383/97 and NA-1508/92. 1
Natural varianti16I → A in strain: NA-1064/97 and NA-1383/97. 1
Natural varianti16I → V in strain: NA-1508/92. 1
Natural varianti27 – 28TT → AA in strain: NA-1064/97, NA-1383/97 and NA-1508/92. 2
Natural varianti30G → S in strain: NA-1064/97. 1
Natural varianti62I → V in strain: NA-1383/97. 1
Natural varianti81E → Q in strain: NA-1383/97. 1
Natural varianti83D → N in strain: TIGR4. 1
Natural varianti120D → E in strain: NA-1064/97, NA-1383/97 and NA-1508/92. 1
Natural varianti130Q → K in strain: NA-1064/97 and NA-1508/92. 1
Natural varianti148I → M in strain: NA-1383/97. 1
Natural varianti164N → S in strain: NA-1383/97. 1
Natural varianti187 – 189SKD → AKE in strain: NA-1383/97. 3
Natural varianti193K → N in strain: NA-1064/97, NA-1383/97 and NA-1508/92. 1
Natural varianti207A → C in strain: NA-1383/97. 1
Natural varianti234E → D in strain: NA-1383/97. 1
Natural varianti248V → T in strain: NA-1383/97. 1
Natural varianti285Q → E in strain: NA-1508/92. 1
Natural varianti294S → N in strain: NA-1383/97. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53509 Genomic DNA. Translation: AAB09440.1.
U40786 Genomic DNA. Translation: AAC24470.1.
AF055088 Genomic DNA. Translation: AAD09975.1.
AF248229 Genomic DNA. Translation: AAF70663.1.
AF248231 Genomic DNA. Translation: AAF70665.1.
AF248232 Genomic DNA. Translation: AAF70666.1.
AF248233 Genomic DNA. Translation: AAF70667.1.
AF248234 Genomic DNA. Translation: AAF70668.1.
AE005672 Genomic DNA. Translation: AAK75729.1.
PIRiH95191.
RefSeqiWP_000733059.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK75729; AAK75729; SP_1650.
KEGGispn:SP_1650.
PATRICi19707735. VBIStrPne105772_1710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53509 Genomic DNA. Translation: AAB09440.1.
U40786 Genomic DNA. Translation: AAC24470.1.
AF055088 Genomic DNA. Translation: AAD09975.1.
AF248229 Genomic DNA. Translation: AAF70663.1.
AF248231 Genomic DNA. Translation: AAF70665.1.
AF248232 Genomic DNA. Translation: AAF70666.1.
AF248233 Genomic DNA. Translation: AAF70667.1.
AF248234 Genomic DNA. Translation: AAF70668.1.
AE005672 Genomic DNA. Translation: AAK75729.1.
PIRiH95191.
RefSeqiWP_000733059.1. NZ_AKVY01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PSZX-ray2.00A19-309[»]
3ZK7X-ray1.69A/B32-309[»]
3ZK8X-ray1.65A/B32-309[»]
3ZK9X-ray1.45A/B32-309[»]
3ZKAX-ray1.55A/B32-309[»]
3ZTTX-ray2.70A/B/C/D19-309[»]
4UTOX-ray1.55A/B1-309[»]
4UTPX-ray2.00A/B1-309[»]
ProteinModelPortaliP0A4G2.
SMRiP0A4G2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SpneT_02000954.

Protein family/group databases

TCDBi3.A.1.15.14. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK75729; AAK75729; SP_1650.
KEGGispn:SP_1650.
PATRICi19707735. VBIStrPne105772_1710.

Phylogenomic databases

eggNOGiENOG4105DSE. Bacteria.
COG0803. LUCA.
KOiK19971.
OMAiHAWQNVA.

Miscellaneous databases

EvolutionaryTraceiP0A4G2.

Family and domain databases

InterProiIPR006129. AdhesinB.
IPR006128. Lipoprotein_4.
IPR006127. ZnuA-like.
[Graphical view]
PfamiPF01297. ZnuA. 1 hit.
[Graphical view]
PRINTSiPR00691. ADHESINB.
PR00690. ADHESNFAMILY.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTSA_STRPN
AccessioniPrimary (citable) accession number: P0A4G2
Secondary accession number(s): P72538
, Q54720, Q9L5X2, Q9L5X3, Q9L5X4, Q9R6P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.