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Protein

Manganese ABC transporter substrate-binding lipoprotein

Gene

psaA

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of an ATP-driven transport system for manganese. Also act as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67ZincCurated1
Metal bindingi139ZincCurated1
Metal bindingi205ZincCurated1
Metal bindingi280ZincCurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandManganese, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSPNE170187:G1FZB-1671-MONOMER

Protein family/group databases

TCDBi3.A.1.15.14 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Manganese ABC transporter substrate-binding lipoprotein
Alternative name(s):
Pneumococcal surface adhesin A
Gene namesi
Name:psaA
Ordered Locus Names:SP_1650
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

  • Cell membrane PROSITE-ProRule annotation; Lipid-anchor PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19PROSITE-ProRule annotationAdd BLAST19
ChainiPRO_000003189120 – 309Manganese ABC transporter substrate-binding lipoproteinAdd BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi20N-palmitoyl cysteinePROSITE-ProRule annotation1
Lipidationi20S-diacylglycerol cysteinePROSITE-ProRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Structurei

Secondary structure

1309
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi27 – 29Combined sources3
Beta strandi33 – 39Combined sources7
Helixi40 – 50Combined sources11
Helixi51 – 53Combined sources3
Beta strandi54 – 60Combined sources7
Beta strandi66 – 68Combined sources3
Helixi73 – 81Combined sources9
Beta strandi83 – 87Combined sources5
Turni90 – 94Combined sources5
Turni96 – 98Combined sources3
Helixi99 – 106Combined sources8
Turni111 – 113Combined sources3
Beta strandi114 – 117Combined sources4
Turni118 – 121Combined sources4
Helixi127 – 129Combined sources3
Helixi140 – 142Combined sources3
Helixi144 – 161Combined sources18
Helixi163 – 165Combined sources3
Helixi166 – 193Combined sources28
Helixi196 – 198Combined sources3
Beta strandi201 – 206Combined sources6
Helixi209 – 215Combined sources7
Beta strandi219 – 223Combined sources5
Helixi233 – 244Combined sources12
Beta strandi251 – 254Combined sources4
Helixi260 – 269Combined sources10
Beta strandi273 – 277Combined sources5
Beta strandi279 – 281Combined sources3
Helixi292 – 307Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PSZX-ray2.00A19-309[»]
3ZK7X-ray1.69A/B32-309[»]
3ZK8X-ray1.65A/B32-309[»]
3ZK9X-ray1.45A/B32-309[»]
3ZKAX-ray1.55A/B32-309[»]
3ZTTX-ray2.70A/B/C/D19-309[»]
4UTOX-ray1.55A/B1-309[»]
4UTPX-ray2.00A/B1-309[»]
ProteinModelPortaliP0A4G2
SMRiP0A4G2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0A4G2

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105DSE Bacteria
COG0803 LUCA
KOiK19971
OMAiPDPHVWG

Family and domain databases

InterProiView protein in InterPro
IPR006129 AdhesinB
IPR006128 Lipoprotein_4
IPR006127 ZnuA-like
PfamiView protein in Pfam
PF01297 ZnuA, 1 hit
PRINTSiPR00691 ADHESINB
PR00690 ADHESNFAMILY
PROSITEiView protein in PROSITE
PS51257 PROKAR_LIPOPROTEIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0A4G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLGTLLVL FLSAIILVAC ASGKKDTTSG QKLKVVATNS IIADITKNIA
60 70 80 90 100
GDKIDLHSIV PIGQDPHEYE PLPEDVKKTS EADLIFYNGI NLETGGNAWF
110 120 130 140 150
TKLVENAKKT ENKDYFAVSD GVDVIYLEGQ NEKGKEDPHA WLNLENGIIF
160 170 180 190 200
AKNIAKQLSA KDPNNKEFYE KNLKEYTDKL DKLDKESKDK FNKIPAEKKL
210 220 230 240 250
IVTSEGAFKY FSKAYGVPSA YIWEINTEEE GTPEQIKTLV EKLRQTKVPS
260 270 280 290 300
LFVESSVDDR PMKTVSQDTN IPIYAQIFTD SIAEQGKEGD SYYSMMKYNL

DKIAEGLAK
Length:309
Mass (Da):34,594
Last modified:March 15, 2005 - v1
Checksum:iB125E7FE3DA6F67C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti8L → F in strain: NA-1508/92. 1
Natural varianti9V → I in strain: NA-1064/97. 1
Natural varianti14A → V in strain: NA-1064/97, NA-1383/97 and NA-1508/92. 1
Natural varianti16I → A in strain: NA-1064/97 and NA-1383/97. 1
Natural varianti16I → V in strain: NA-1508/92. 1
Natural varianti27 – 28TT → AA in strain: NA-1064/97, NA-1383/97 and NA-1508/92. 2
Natural varianti30G → S in strain: NA-1064/97. 1
Natural varianti62I → V in strain: NA-1383/97. 1
Natural varianti81E → Q in strain: NA-1383/97. 1
Natural varianti83D → N in strain: TIGR4. 1
Natural varianti120D → E in strain: NA-1064/97, NA-1383/97 and NA-1508/92. 1
Natural varianti130Q → K in strain: NA-1064/97 and NA-1508/92. 1
Natural varianti148I → M in strain: NA-1383/97. 1
Natural varianti164N → S in strain: NA-1383/97. 1
Natural varianti187 – 189SKD → AKE in strain: NA-1383/97. 3
Natural varianti193K → N in strain: NA-1064/97, NA-1383/97 and NA-1508/92. 1
Natural varianti207A → C in strain: NA-1383/97. 1
Natural varianti234E → D in strain: NA-1383/97. 1
Natural varianti248V → T in strain: NA-1383/97. 1
Natural varianti285Q → E in strain: NA-1508/92. 1
Natural varianti294S → N in strain: NA-1383/97. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53509 Genomic DNA Translation: AAB09440.1
U40786 Genomic DNA Translation: AAC24470.1
AF055088 Genomic DNA Translation: AAD09975.1
AF248229 Genomic DNA Translation: AAF70663.1
AF248231 Genomic DNA Translation: AAF70665.1
AF248232 Genomic DNA Translation: AAF70666.1
AF248233 Genomic DNA Translation: AAF70667.1
AF248234 Genomic DNA Translation: AAF70668.1
AE005672 Genomic DNA Translation: AAK75729.1
PIRiH95191
RefSeqiWP_000733059.1, NZ_AKVY01000001.1

Genome annotation databases

EnsemblBacteriaiAAK75729; AAK75729; SP_1650
KEGGispn:SP_1650

Similar proteinsi

Entry informationi

Entry nameiMTSA_STRPN
AccessioniPrimary (citable) accession number: P0A4G2
Secondary accession number(s): P72538
, Q54720, Q9L5X2, Q9L5X3, Q9L5X4, Q9R6P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 25, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome
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Main funding by: National Institutes of Health