P0A4E2 (GLK_STRLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucokinase
EC=2.7.1.2

Alternative name(s):
Glucose kinase

Gene names

Name:	glkA
Synonyms:	glk

Organism

Streptomyces lividans

Taxonomic identifier

1916 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for glucose repression of many different genes.
Catalytic activity	ATP + D-glucose = ADP + D-glucose 6-phosphate.
Subunit structure	Homooligomer (possibly a homotetramer). Alternatively, it may form a heterotetramer of two glucokinase subunits with two ORF2 (AC P40182) proteins.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the ROK (NagC/XylR) family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Repressor Transferase
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glucokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Glucokinase		PRO_0000095678

Sequences

	Sequence		Length	Mass (Da)
	P0A4E2 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 6E65A97691BA15BF	FASTA	317	33,062
	10 20 30 40 50 60 MGLTIGVDIG GTKIAAGVVD EEGNILSTHK VPTPTTPEAI VDAIASAVEG ARVGHEIVAV 70 80 90 100 110 120 GIGAAGYVNR QRSTVYFAPN IDWRQEPLKE KVEARVGLPV VVENDANAAA WGEYKFGGGK 130 140 150 160 170 180 GHRNVICITL GTGLGGGIII GNKLRRGHFG VAAEFGHIRM VPDGLLCGCG SQGCWEQYAS 190 200 210 220 230 240 GRALVRYAKQ RANATPERAE VLLALGDGTP DGIEGKHISV AARQGCPVAV DSYRELARWA 250 260 270 280 290 300 GAGLADLASL FDPSAFIVGG GLSDEGDLVL DPIRKSYKRW LVGGNWRPVA DVIAAQLGNK 310 AGLVGAADLA REPDPIM

References

[1]

"Glucose kinase of Streptomyces coelicolor A3(2): large-scale purification and biochemical analysis." Mahr K., van Wezel G.P., Svensson C., Krengel U., Bibb M.J., Titgemeyer F. Antonie Van Leeuwenhoek 78:253-261(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION. Strain: TK24.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF228048 Genomic DNA. Translation: AAF42869.1.
3D structure databases
ProteinModelPortal	P0A4E2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	25373567. VBIStrLiv48540_3630.
Family and domain databases
InterPro	IPR000600. ROK. IPR004654. ROK_glcA. [Graphical view]
Pfam	PF00480. ROK. 1 hit. [Graphical view]
TIGRFAMs	TIGR00744. ROK_glcA_fam. 1 hit.
PROSITE	PS01125. ROK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLK_STRLI

Accession

Primary (citable) accession number: P0A4E2
Secondary accession number(s): P40184

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	April 3, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program