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Protein

Glucokinase

Gene

glkA

Organism
Streptomyces lividans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for glucose repression of many different genes.

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Repressor, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glucokinase (EC:2.7.1.2)
Alternative name(s):
Glucose kinase
Gene namesi
Name:glkA
Synonyms:glk
OrganismiStreptomyces lividans
Taxonomic identifieri1916 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000956781 – 317GlucokinaseAdd BLAST317

Interactioni

Subunit structurei

Homooligomer (possibly a homotetramer). Alternatively, it may form a heterotetramer of two glucokinase subunits with two ORF2 (AC P40182) proteins.

Structurei

3D structure databases

ProteinModelPortaliP0A4E2.
SMRiP0A4E2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR000600. ROK.
IPR004654. ROK_glcA.
PANTHERiPTHR18964. PTHR18964. 1 hit.
PfamiView protein in Pfam
PF00480. ROK. 1 hit.
TIGRFAMsiTIGR00744. ROK_glcA_fam. 1 hit.
PROSITEiView protein in PROSITE
PS01125. ROK. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A4E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTIGVDIG GTKIAAGVVD EEGNILSTHK VPTPTTPEAI VDAIASAVEG
60 70 80 90 100
ARVGHEIVAV GIGAAGYVNR QRSTVYFAPN IDWRQEPLKE KVEARVGLPV
110 120 130 140 150
VVENDANAAA WGEYKFGGGK GHRNVICITL GTGLGGGIII GNKLRRGHFG
160 170 180 190 200
VAAEFGHIRM VPDGLLCGCG SQGCWEQYAS GRALVRYAKQ RANATPERAE
210 220 230 240 250
VLLALGDGTP DGIEGKHISV AARQGCPVAV DSYRELARWA GAGLADLASL
260 270 280 290 300
FDPSAFIVGG GLSDEGDLVL DPIRKSYKRW LVGGNWRPVA DVIAAQLGNK
310
AGLVGAADLA REPDPIM
Length:317
Mass (Da):33,062
Last modified:March 15, 2005 - v1
Checksum:i6E65A97691BA15BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF228048 Genomic DNA. Translation: AAF42869.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGLK_STRLI
AccessioniPrimary (citable) accession number: P0A4E2
Secondary accession number(s): P40184
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 7, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families