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P0A4E2

- GLK_STRLI

UniProt

P0A4E2 - GLK_STRLI

Protein

Glucokinase

Gene

glkA

Organism
Streptomyces lividans
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Required for glucose repression of many different genes.

    Catalytic activityi

    ATP + D-glucose = ADP + D-glucose 6-phosphate.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glucokinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Repressor, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucokinase (EC:2.7.1.2)
    Alternative name(s):
    Glucose kinase
    Gene namesi
    Name:glkA
    Synonyms:glk
    OrganismiStreptomyces lividans
    Taxonomic identifieri1916 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317GlucokinasePRO_0000095678Add
    BLAST

    Interactioni

    Subunit structurei

    Homooligomer (possibly a homotetramer). Alternatively, it may form a heterotetramer of two glucokinase subunits with two ORF2 (AC P40182) proteins.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A4E2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ROK (NagC/XylR) family.Curated

    Family and domain databases

    InterProiIPR000600. ROK.
    IPR004654. ROK_glcA.
    [Graphical view]
    PfamiPF00480. ROK. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00744. ROK_glcA_fam. 1 hit.
    PROSITEiPS01125. ROK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A4E2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLTIGVDIG GTKIAAGVVD EEGNILSTHK VPTPTTPEAI VDAIASAVEG    50
    ARVGHEIVAV GIGAAGYVNR QRSTVYFAPN IDWRQEPLKE KVEARVGLPV 100
    VVENDANAAA WGEYKFGGGK GHRNVICITL GTGLGGGIII GNKLRRGHFG 150
    VAAEFGHIRM VPDGLLCGCG SQGCWEQYAS GRALVRYAKQ RANATPERAE 200
    VLLALGDGTP DGIEGKHISV AARQGCPVAV DSYRELARWA GAGLADLASL 250
    FDPSAFIVGG GLSDEGDLVL DPIRKSYKRW LVGGNWRPVA DVIAAQLGNK 300
    AGLVGAADLA REPDPIM 317
    Length:317
    Mass (Da):33,062
    Last modified:March 15, 2005 - v1
    Checksum:i6E65A97691BA15BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF228048 Genomic DNA. Translation: AAF42869.1.

    Genome annotation databases

    PATRICi25373567. VBIStrLiv48540_3630.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF228048 Genomic DNA. Translation: AAF42869.1 .

    3D structure databases

    ProteinModelPortali P0A4E2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    PATRICi 25373567. VBIStrLiv48540_3630.

    Family and domain databases

    InterProi IPR000600. ROK.
    IPR004654. ROK_glcA.
    [Graphical view ]
    Pfami PF00480. ROK. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00744. ROK_glcA_fam. 1 hit.
    PROSITEi PS01125. ROK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Glucose kinase of Streptomyces coelicolor A3(2): large-scale purification and biochemical analysis."
      Mahr K., van Wezel G.P., Svensson C., Krengel U., Bibb M.J., Titgemeyer F.
      Antonie Van Leeuwenhoek 78:253-261(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
      Strain: TK24.

    Entry informationi

    Entry nameiGLK_STRLI
    AccessioniPrimary (citable) accession number: P0A4E2
    Secondary accession number(s): P40184
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3