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P0A4E2

- GLK_STRLI

UniProt

P0A4E2 - GLK_STRLI

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Protein

Glucokinase

Gene
glkA, glk
Organism
Streptomyces lividans
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Required for glucose repression of many different genes.

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glucokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Repressor, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glucokinase (EC:2.7.1.2)
Alternative name(s):
Glucose kinase
Gene namesi
Name:glkA
Synonyms:glk
OrganismiStreptomyces lividans
Taxonomic identifieri1916 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317GlucokinasePRO_0000095678Add
BLAST

Interactioni

Subunit structurei

Homooligomer (possibly a homotetramer). Alternatively, it may form a heterotetramer of two glucokinase subunits with two ORF2 (AC P40182) proteins.

Structurei

3D structure databases

ProteinModelPortaliP0A4E2.

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family.

Family and domain databases

InterProiIPR000600. ROK.
IPR004654. ROK_glcA.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00744. ROK_glcA_fam. 1 hit.
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A4E2-1 [UniParc]FASTAAdd to Basket

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MGLTIGVDIG GTKIAAGVVD EEGNILSTHK VPTPTTPEAI VDAIASAVEG    50
ARVGHEIVAV GIGAAGYVNR QRSTVYFAPN IDWRQEPLKE KVEARVGLPV 100
VVENDANAAA WGEYKFGGGK GHRNVICITL GTGLGGGIII GNKLRRGHFG 150
VAAEFGHIRM VPDGLLCGCG SQGCWEQYAS GRALVRYAKQ RANATPERAE 200
VLLALGDGTP DGIEGKHISV AARQGCPVAV DSYRELARWA GAGLADLASL 250
FDPSAFIVGG GLSDEGDLVL DPIRKSYKRW LVGGNWRPVA DVIAAQLGNK 300
AGLVGAADLA REPDPIM 317
Length:317
Mass (Da):33,062
Last modified:March 15, 2005 - v1
Checksum:i6E65A97691BA15BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF228048 Genomic DNA. Translation: AAF42869.1.

Genome annotation databases

PATRICi25373567. VBIStrLiv48540_3630.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF228048 Genomic DNA. Translation: AAF42869.1 .

3D structure databases

ProteinModelPortali P0A4E2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

PATRICi 25373567. VBIStrLiv48540_3630.

Family and domain databases

InterProi IPR000600. ROK.
IPR004654. ROK_glcA.
[Graphical view ]
Pfami PF00480. ROK. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00744. ROK_glcA_fam. 1 hit.
PROSITEi PS01125. ROK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Glucose kinase of Streptomyces coelicolor A3(2): large-scale purification and biochemical analysis."
    Mahr K., van Wezel G.P., Svensson C., Krengel U., Bibb M.J., Titgemeyer F.
    Antonie Van Leeuwenhoek 78:253-261(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION.
    Strain: TK24.

Entry informationi

Entry nameiGLK_STRLI
AccessioniPrimary (citable) accession number: P0A4E2
Secondary accession number(s): P40184
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 11, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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