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P0A4E1 (GLK_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucokinase

EC=2.7.1.2
Alternative name(s):
Glucose kinase
Gene names
Name:glkA
Synonyms:glk
Ordered Locus Names:SCO2126
ORF Names:SC6E10.20c
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length317 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for glucose repression of many different genes.

Catalytic activity

ATP + D-glucose = ADP + D-glucose 6-phosphate.

Subunit structure

Homooligomer (possibly a homotetramer). Alternatively, it may form a heterotetramer of two glucokinase subunits with two ORF2 (AC P40182) proteins.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the ROK (NagC/XylR) family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Repressor
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glucokinase activity

Inferred from mutant phenotype Ref.1. Source: CACAO

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 317317Glucokinase
PRO_0000095677

Sequences

Sequence LengthMass (Da)Tools
P0A4E1 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 6E65A97691BA15BF

FASTA31733,062
        10         20         30         40         50         60 
MGLTIGVDIG GTKIAAGVVD EEGNILSTHK VPTPTTPEAI VDAIASAVEG ARVGHEIVAV 

        70         80         90        100        110        120 
GIGAAGYVNR QRSTVYFAPN IDWRQEPLKE KVEARVGLPV VVENDANAAA WGEYKFGGGK 

       130        140        150        160        170        180 
GHRNVICITL GTGLGGGIII GNKLRRGHFG VAAEFGHIRM VPDGLLCGCG SQGCWEQYAS 

       190        200        210        220        230        240 
GRALVRYAKQ RANATPERAE VLLALGDGTP DGIEGKHISV AARQGCPVAV DSYRELARWA 

       250        260        270        280        290        300 
GAGLADLASL FDPSAFIVGG GLSDEGDLVL DPIRKSYKRW LVGGNWRPVA DVIAAQLGNK 

       310 
AGLVGAADLA REPDPIM 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X65932 Genomic DNA. Translation: CAA46727.1.
AL939111 Genomic DNA. Translation: CAB51974.1.
PIRS26208.
RefSeqNP_626383.1. NC_003888.3.

3D structure databases

ProteinModelPortalP0A4E1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO2126.

Proteomic databases

PRIDEP0A4E1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB51974; CAB51974; CAB51974.
GeneID1097560.
KEGGsco:SCO2126.
PATRIC23733904. VBIStrCoe124346_2161.

Phylogenomic databases

eggNOGCOG1940.
HOGENOMHOG000150087.
KOK00845.
OMAFEPEVIC.
OrthoDBEOG654P64.
PhylomeDBP0A4E1.
ProtClustDBCLSK501865.

Enzyme and pathway databases

BRENDA2.7.1.2. 5998.

Family and domain databases

InterProIPR000600. ROK.
IPR004654. ROK_glcA.
[Graphical view]
PfamPF00480. ROK. 1 hit.
[Graphical view]
TIGRFAMsTIGR00744. ROK_glcA_fam. 1 hit.
PROSITEPS01125. ROK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLK_STRCO
AccessionPrimary (citable) accession number: P0A4E1
Secondary accession number(s): P40184
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families