P0A4E1 (GLK_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucokinase
EC=2.7.1.2

Alternative name(s):
Glucose kinase

Gene names

Name:	glkA
Synonyms:	glk
Ordered Locus Names:	SCO2126
ORF Names:	SC6E10.20c

Organism

Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]

Taxonomic identifier

100226 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces › Streptomyces coelicolor

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for glucose repression of many different genes.
Catalytic activity	ATP + D-glucose = ADP + D-glucose 6-phosphate.
Subunit structure	Homooligomer (possibly a homotetramer). Alternatively, it may form a heterotetramer of two glucokinase subunits with two ORF2 (AC P40182) proteins.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the ROK (NagC/XylR) family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Repressor Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glucokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Glucokinase		PRO_0000095677

Sequences

	Sequence		Length	Mass (Da)
	P0A4E1 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 6E65A97691BA15BF	FASTA	317	33,062
	10 20 30 40 50 60 MGLTIGVDIG GTKIAAGVVD EEGNILSTHK VPTPTTPEAI VDAIASAVEG ARVGHEIVAV 70 80 90 100 110 120 GIGAAGYVNR QRSTVYFAPN IDWRQEPLKE KVEARVGLPV VVENDANAAA WGEYKFGGGK 130 140 150 160 170 180 GHRNVICITL GTGLGGGIII GNKLRRGHFG VAAEFGHIRM VPDGLLCGCG SQGCWEQYAS 190 200 210 220 230 240 GRALVRYAKQ RANATPERAE VLLALGDGTP DGIEGKHISV AARQGCPVAV DSYRELARWA 250 260 270 280 290 300 GAGLADLASL FDPSAFIVGG GLSDEGDLVL DPIRKSYKRW LVGGNWRPVA DVIAAQLGNK 310 AGLVGAADLA REPDPIM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The glucose kinase gene of Streptomyces coelicolor A3(2): its nucleotide sequence, transcriptional analysis and role in glucose repression." Angell S., Schwarz E., Bibb M.J. Mol. Microbiol. 6:2833-2844(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: A3(2) / NRRL B-16638.
[2]	"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X65932 Genomic DNA. Translation: CAA46727.1. AL939111 Genomic DNA. Translation: CAB51974.1.
PIR	S26208.
RefSeq	NP_626383.1. NC_003888.3.
3D structure databases
ProteinModelPortal	P0A4E1.
ModBase	Search...
Protein-protein interaction databases
STRING	100226.SCO2126.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB51974; CAB51974; CAB51974.
GeneID	1097560.
KEGG	sco:SCO2126.
PATRIC	23733904. VBIStrCoe124346_2161.
Phylogenomic databases
eggNOG	COG1940.
HOGENOM	HOG000150087.
KO	K00845.
OMA	EMTKGRE.
ProtClustDB	CLSK501865.
Enzyme and pathway databases
BRENDA	2.7.1.2. 5998.
Family and domain databases
InterPro	IPR000600. ROK. IPR004654. ROK_glcA. [Graphical view]
Pfam	PF00480. ROK. 1 hit. [Graphical view]
TIGRFAMs	TIGR00744. ROK_glcA_fam. 1 hit.
PROSITE	PS01125. ROK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLK_STRCO

Accession

Primary (citable) accession number: P0A4E1
Secondary accession number(s): P40184

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program