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P0A4E1

- GLK_STRCO

UniProt

P0A4E1 - GLK_STRCO

Protein

Glucokinase

Gene

glkA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Required for glucose repression of many different genes.

    Catalytic activityi

    ATP + D-glucose = ADP + D-glucose 6-phosphate.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glucokinase activity Source: CACAO

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Repressor, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.1.2. 5998.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucokinase (EC:2.7.1.2)
    Alternative name(s):
    Glucose kinase
    Gene namesi
    Name:glkA
    Synonyms:glk
    Ordered Locus Names:SCO2126
    ORF Names:SC6E10.20c
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317GlucokinasePRO_0000095677Add
    BLAST

    Proteomic databases

    PRIDEiP0A4E1.

    Interactioni

    Subunit structurei

    Homooligomer (possibly a homotetramer). Alternatively, it may form a heterotetramer of two glucokinase subunits with two ORF2 (AC P40182) proteins.

    Protein-protein interaction databases

    STRINGi100226.SCO2126.

    Structurei

    3D structure databases

    ProteinModelPortaliP0A4E1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ROK (NagC/XylR) family.Curated

    Phylogenomic databases

    eggNOGiCOG1940.
    HOGENOMiHOG000150087.
    KOiK00845.
    OMAiKQRANAT.
    OrthoDBiEOG654P64.
    PhylomeDBiP0A4E1.

    Family and domain databases

    InterProiIPR000600. ROK.
    IPR004654. ROK_glcA.
    [Graphical view]
    PfamiPF00480. ROK. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00744. ROK_glcA_fam. 1 hit.
    PROSITEiPS01125. ROK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0A4E1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLTIGVDIG GTKIAAGVVD EEGNILSTHK VPTPTTPEAI VDAIASAVEG    50
    ARVGHEIVAV GIGAAGYVNR QRSTVYFAPN IDWRQEPLKE KVEARVGLPV 100
    VVENDANAAA WGEYKFGGGK GHRNVICITL GTGLGGGIII GNKLRRGHFG 150
    VAAEFGHIRM VPDGLLCGCG SQGCWEQYAS GRALVRYAKQ RANATPERAE 200
    VLLALGDGTP DGIEGKHISV AARQGCPVAV DSYRELARWA GAGLADLASL 250
    FDPSAFIVGG GLSDEGDLVL DPIRKSYKRW LVGGNWRPVA DVIAAQLGNK 300
    AGLVGAADLA REPDPIM 317
    Length:317
    Mass (Da):33,062
    Last modified:March 15, 2005 - v1
    Checksum:i6E65A97691BA15BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65932 Genomic DNA. Translation: CAA46727.1.
    AL939111 Genomic DNA. Translation: CAB51974.1.
    PIRiS26208.
    RefSeqiNP_626383.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB51974; CAB51974; CAB51974.
    GeneIDi1097560.
    KEGGisco:SCO2126.
    PATRICi23733904. VBIStrCoe124346_2161.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X65932 Genomic DNA. Translation: CAA46727.1 .
    AL939111 Genomic DNA. Translation: CAB51974.1 .
    PIRi S26208.
    RefSeqi NP_626383.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali P0A4E1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO2126.

    Proteomic databases

    PRIDEi P0A4E1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB51974 ; CAB51974 ; CAB51974 .
    GeneIDi 1097560.
    KEGGi sco:SCO2126.
    PATRICi 23733904. VBIStrCoe124346_2161.

    Phylogenomic databases

    eggNOGi COG1940.
    HOGENOMi HOG000150087.
    KOi K00845.
    OMAi KQRANAT.
    OrthoDBi EOG654P64.
    PhylomeDBi P0A4E1.

    Enzyme and pathway databases

    BRENDAi 2.7.1.2. 5998.

    Family and domain databases

    InterProi IPR000600. ROK.
    IPR004654. ROK_glcA.
    [Graphical view ]
    Pfami PF00480. ROK. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00744. ROK_glcA_fam. 1 hit.
    PROSITEi PS01125. ROK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The glucose kinase gene of Streptomyces coelicolor A3(2): its nucleotide sequence, transcriptional analysis and role in glucose repression."
      Angell S., Schwarz E., Bibb M.J.
      Mol. Microbiol. 6:2833-2844(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: A3(2) / NRRL B-16638.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiGLK_STRCO
    AccessioniPrimary (citable) accession number: P0A4E1
    Secondary accession number(s): P40184
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3