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Protein

Glucokinase

Gene

glkA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for glucose repression of many different genes.

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glucokinase activity Source: CACAO

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Repressor, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.2. 5998.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucokinase (EC:2.7.1.2)
Alternative name(s):
Glucose kinase
Gene namesi
Name:glkA
Synonyms:glk
Ordered Locus Names:SCO2126
ORF Names:SC6E10.20c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317GlucokinasePRO_0000095677Add
BLAST

Proteomic databases

PRIDEiP0A4E1.

Interactioni

Subunit structurei

Homooligomer (possibly a homotetramer). Alternatively, it may form a heterotetramer of two glucokinase subunits with two ORF2 (AC P40182) proteins.

Protein-protein interaction databases

STRINGi100226.SCO2126.

Structurei

3D structure databases

ProteinModelPortaliP0A4E1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family.Curated

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
InParanoidiP0A4E1.
KOiK00845.
OMAiQGCWEQY.
OrthoDBiEOG654P64.
PhylomeDBiP0A4E1.

Family and domain databases

InterProiIPR000600. ROK.
IPR004654. ROK_glcA.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00744. ROK_glcA_fam. 1 hit.
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0A4E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTIGVDIG GTKIAAGVVD EEGNILSTHK VPTPTTPEAI VDAIASAVEG
60 70 80 90 100
ARVGHEIVAV GIGAAGYVNR QRSTVYFAPN IDWRQEPLKE KVEARVGLPV
110 120 130 140 150
VVENDANAAA WGEYKFGGGK GHRNVICITL GTGLGGGIII GNKLRRGHFG
160 170 180 190 200
VAAEFGHIRM VPDGLLCGCG SQGCWEQYAS GRALVRYAKQ RANATPERAE
210 220 230 240 250
VLLALGDGTP DGIEGKHISV AARQGCPVAV DSYRELARWA GAGLADLASL
260 270 280 290 300
FDPSAFIVGG GLSDEGDLVL DPIRKSYKRW LVGGNWRPVA DVIAAQLGNK
310
AGLVGAADLA REPDPIM
Length:317
Mass (Da):33,062
Last modified:March 15, 2005 - v1
Checksum:i6E65A97691BA15BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65932 Genomic DNA. Translation: CAA46727.1.
AL939111 Genomic DNA. Translation: CAB51974.1.
PIRiS26208.
RefSeqiNP_626383.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB51974; CAB51974; CAB51974.
GeneIDi1097560.
KEGGisco:SCO2126.
PATRICi23733904. VBIStrCoe124346_2161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X65932 Genomic DNA. Translation: CAA46727.1.
AL939111 Genomic DNA. Translation: CAB51974.1.
PIRiS26208.
RefSeqiNP_626383.1. NC_003888.3.

3D structure databases

ProteinModelPortaliP0A4E1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO2126.

Proteomic databases

PRIDEiP0A4E1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB51974; CAB51974; CAB51974.
GeneIDi1097560.
KEGGisco:SCO2126.
PATRICi23733904. VBIStrCoe124346_2161.

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
InParanoidiP0A4E1.
KOiK00845.
OMAiQGCWEQY.
OrthoDBiEOG654P64.
PhylomeDBiP0A4E1.

Enzyme and pathway databases

BRENDAi2.7.1.2. 5998.

Family and domain databases

InterProiIPR000600. ROK.
IPR004654. ROK_glcA.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00744. ROK_glcA_fam. 1 hit.
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The glucose kinase gene of Streptomyces coelicolor A3(2): its nucleotide sequence, transcriptional analysis and role in glucose repression."
    Angell S., Schwarz E., Bibb M.J.
    Mol. Microbiol. 6:2833-2844(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A3(2) / NRRL B-16638.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiGLK_STRCO
AccessioniPrimary (citable) accession number: P0A4E1
Secondary accession number(s): P40184
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: January 7, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.