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Protein

Ribonuclease HII

Gene

rnhB

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.By similarity

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.

Cofactori

Mn2+By similarity, Mg2+By similarityNote: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi38Divalent metal cationBy similarity1
Metal bindingi39Divalent metal cationBy similarity1
Metal bindingi130Divalent metal cationBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HII (EC:3.1.26.4)
Short name:
RNase HII
Gene namesi
Name:rnhB
Ordered Locus Names:BMEI1542
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001115511 – 220Ribonuclease HIIAdd BLAST220

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_0683.

Structurei

3D structure databases

ProteinModelPortaliP0A4D9.
SMRiP0A4D9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family.Curated

Phylogenomic databases

eggNOGiENOG4108UH2. Bacteria.
COG0164. LUCA.
HOGENOMiHOG000100288.
KOiK03470.
OMAiNILHASM.

Family and domain databases

CDDicd07182. RNase_HII_bacteria_HII_like. 1 hit.
Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00052_B. RNase_HII_B. 1 hit.
InterProiView protein in InterPro
IPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_sf.
IPR036397. RNaseH_sf.
PANTHERiPTHR10954. PTHR10954. 1 hit.
PTHR10954:SF18. PTHR10954:SF18. 1 hit.
PfamiView protein in Pfam
PF01351. RNase_HII. 1 hit.
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

P0A4D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRSASDSPL LFDLPLAPDF SQEQQLMKRG LKHIAGIDEA GRGPLAGPVV
60 70 80 90 100
AAAVVLDQND LPEGLDDSKR LTAARREALY EIILTKAITV SVASLSARSI
110 120 130 140 150
DASDIRKAAL EAMRRAVIGL TLKPCHALVD GRDVPPGLPC PGSALVKGDQ
160 170 180 190 200
RSVSIAAASI VAKVTRDRMM IRAGAAHPPY GLEIHAGYAT QKHRAAIESE
210 220
GPVPGLHRYT FAPIKGRFDC
Length:220
Mass (Da):23,385
Last modified:March 15, 2005 - v1
Checksum:i87E3AB0664844E8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF054610 Genomic DNA. Translation: AAC08032.1.
AE008917 Genomic DNA. Translation: AAL52723.1.
PIRiAH3444.
RefSeqiWP_004683016.1. NZ_GG703778.1.

Genome annotation databases

EnsemblBacteriaiAAL52723; AAL52723; BMEI1542.
GeneIDi29594389.
KEGGibme:BMEI1542.

Similar proteinsi

Entry informationi

Entry nameiRNH2_BRUME
AccessioniPrimary (citable) accession number: P0A4D9
Secondary accession number(s): O68821
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 22, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families